Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 27, 2012, Pages

  Fukuda, Daiju ^a   Aikawa, Elena ^a   Swirski, Filip K ^b   Novobrantseva, Tatiana I ^c   Kotelianski, Victor ^c   Gorgun, Cem Z ^d   Chudnovskiy, Aleksey ^b   Yamazaki, Hiroyuki ^a   Croce, Kevin ^a   Weissleder, Ralph ^b   Aster, Jon C ^a   Hotamisligil, Gökhan S ^d   Yagita, Hideo ^e   Aikawa, Masanori ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Biotherapy; Cardiovascular diseases; Collagen; Diabetes mellitus; Obesity

Indexed keywords

ADIPONECTIN; BONE MORPHOGENETIC PROTEIN 2; CCAAT ENHANCER BINDING PROTEIN ALPHA; COLLAGENASE 3; GELATINASE B; GLUCOSE TRANSPORTER 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR; MANNOSE RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; NOTCH LIGAND DELTA LIKE 4; NOTCH RECEPTOR; SCAVENGER RECEPTOR A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; ATTENUATION; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MACROPHAGE; METABOLIC DISORDER; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ANTIBODIES, NEUTRALIZING; AORTIC VALVE INSUFFICIENCY; ATHEROSCLEROSIS; CHEMOKINE CCL2; ENDOTHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MEMBRANE PROTEINS; METABOLIC SYNDROME X; MICE; MICE, OBESE; MICE, TRANSGENIC; RECEPTORS, LDL; RECEPTORS, NOTCH; SAPHENOUS VEIN; SIGNAL TRANSDUCTION;

MUS;

EID: 84863605556     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116889109     Document Type: Article

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