메뉴 건너뛰기




Volumn 7, Issue , 2017, Pages

Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; KEAP1 PROTEIN, MOUSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MEQUINDOX; NFE2L2 PROTEIN, MOUSE; QUINOXALINE DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

EID: 85011588248     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep41854     Document Type: Article
Times cited : (33)

References (74)
  • 1
    • 84942848328 scopus 로고    scopus 로고
    • Systematic and molecular basis of the antibacterial action of quinoxaline 1,4-Di-N-oxides against Escherichia coli
    • Cheng, G. et al. Systematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coli. Plos one 10, e0136450 (2015).
    • (2015) Plos One , vol.10 , pp. e0136450
    • Cheng, G.1
  • 2
    • 84969244083 scopus 로고    scopus 로고
    • Further investigations into the genotoxicity of quinoxaline-di-N-oxides and their primary metabolites
    • Liu, Q. Y. et al. Further investigations into the genotoxicity of quinoxaline-di-N-oxides and their primary metabolites. Food Chem Toxicol 93, 145-157 (2016).
    • (2016) Food Chem Toxicol , vol.93 , pp. 145-157
    • Liu, Q.Y.1
  • 3
    • 57649196329 scopus 로고    scopus 로고
    • Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides
    • Vicente, E. et al. Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides. Bioorgan Med Chem 17, 385-389 (2009).
    • (2009) Bioorgan Med Chem , vol.17 , pp. 385-389
    • Vicente, E.1
  • 4
    • 79953042628 scopus 로고    scopus 로고
    • Two generation reproduction and teratogenicity studies of feeding cyadox in Wistar rats
    • Wang, X. et al. Two generation reproduction and teratogenicity studies of feeding cyadox in Wistar rats. Food Chem Toxicol 49, 1068-1079 (2011).
    • (2011) Food Chem Toxicol , vol.49 , pp. 1068-1079
    • Wang, X.1
  • 5
    • 85011602662 scopus 로고    scopus 로고
    • Genotoxic risk of quinocetone and its possible mechanism in in-vitro studies
    • Wang, X. et al. Genotoxic risk of quinocetone and its possible mechanism in in-vitro studies. Toxicol Res, doi: 10.1039/C1035TX00341E (2015).
    • (2015) Toxicol Res
    • Wang, X.1
  • 6
    • 84924915127 scopus 로고    scopus 로고
    • Deoxidation rates play a critical role in DNA damage mediated by important synthetic drugs, quinoxaline 1,4-dioxides
    • Wang, X. et al. Deoxidation rates play a critical role in DNA damage mediated by important synthetic drugs, quinoxaline 1,4-dioxides. Chem Res Toxicol 28, 470-481 (2015).
    • (2015) Chem Res Toxicol , vol.28 , pp. 470-481
    • Wang, X.1
  • 7
    • 33847683447 scopus 로고    scopus 로고
    • Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline- 2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues
    • Wu, Y. et al. Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline- 2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues. J Chromatogr A 1146, 1-7 (2007).
    • (2007) J Chromatogr A , vol.1146 , pp. 1-7
    • Wu, Y.1
  • 8
    • 84922523115 scopus 로고    scopus 로고
    • Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and compared with its metabolites
    • Zhang, K. et al. Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and compared with its metabolites. Environ Toxicol Pha 39, 555-567 (2015).
    • (2015) Environ Toxicol Pha , vol.39 , pp. 555-567
    • Zhang, K.1
  • 9
    • 23844472369 scopus 로고    scopus 로고
    • Quinoxaline 1,4-dioxide: A versatile scaffold endowed with manifold activities
    • Carta, A., Corona, P. & Loriga, M. Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities. Curr Med Chem 12, 2259-2272 (2005).
    • (2005) Curr Med Chem , vol.12 , pp. 2259-2272
    • Carta, A.1    Corona, P.2    Loriga, M.3
  • 10
    • 58149483488 scopus 로고    scopus 로고
    • Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells
    • Chen, Q. et al. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem Toxicol 47, 328-334 (2009).
    • (2009) Food Chem Toxicol , vol.47 , pp. 328-334
    • Chen, Q.1
  • 11
    • 77953358204 scopus 로고    scopus 로고
    • Acute and subchronic toxicological evaluation of Mequindox in Wistar rats
    • Ihsan, A. et al. Acute and subchronic toxicological evaluation of Mequindox in Wistar rats. Regul Toxicol Phar 57, 307-314 (2010).
    • (2010) Regul Toxicol Phar , vol.57 , pp. 307-314
    • Ihsan, A.1
  • 12
    • 79954629408 scopus 로고    scopus 로고
    • Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats
    • Ihsan, A. et al. Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats. Toxicol Appl Pharm 252, 281-288 (2011).
    • (2011) Toxicol Appl Pharm , vol.252 , pp. 281-288
    • Ihsan, A.1
  • 13
    • 84880096572 scopus 로고    scopus 로고
    • Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo
    • Ihsan, A. et al. Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo. Food Chem Toxicol 59, 207-214 (2013).
    • (2013) Food Chem Toxicol , vol.59 , pp. 207-214
    • Ihsan, A.1
  • 14
    • 84946926060 scopus 로고    scopus 로고
    • Metabolism, distribution, and elimination of mequindox in pigs, chickens, and rats
    • Huang, L. et al. Metabolism, Distribution, and Elimination of Mequindox in Pigs, Chickens, and Rats. J Agri Food Chem 63, 9839-9849 (2015).
    • (2015) J Agri Food Chem , vol.63 , pp. 9839-9849
    • Huang, L.1
  • 15
    • 84964499432 scopus 로고    scopus 로고
    • Quinoxaline 1,4-di-N-Oxides: Biological activities and mechanisms of actions
    • Cheng, G. et al. Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions. Front Pharmacol 7, 64 (2016).
    • (2016) Front Pharmacol , vol.7 , pp. 64
    • Cheng, G.1
  • 16
    • 37849028998 scopus 로고    scopus 로고
    • Characterization of carbadox-induced mutagenesis using a shuttle vector PSP189 in mammalian cells
    • Chen, Q. et al. Characterization of carbadox-induced mutagenesis using a shuttle vector PSP189 in mammalian cells. Mutat Res 638, 11-16 (2008).
    • (2008) Mutat Res , vol.638 , pp. 11-16
    • Chen, Q.1
  • 17
    • 33745924404 scopus 로고    scopus 로고
    • Molecular mechanism of mutagenesis induced by olaquindox using a shuttle vector pSP189/mammalian cell system
    • 2006
    • Hao, L., Chen, Q. & Xiao, X. 2006. Molecular mechanism of mutagenesis induced by olaquindox using a shuttle vector pSP189/mammalian cell system. Mutat Res 599, 21-25 (2006).
    • (2006) Mutat Res , vol.599 , pp. 21-25
    • Hao, L.1    Chen, Q.2    Xiao, X.3
  • 18
    • 0034830902 scopus 로고    scopus 로고
    • Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide
    • Ganley, B., Chowdhury, G., Bhansali, J., Daniels, J. S. & Gates, K. S. Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide. Bioorgan Med Chem 9, 2395-2401 (2001).
    • (2001) Bioorgan Med Chem , vol.9 , pp. 2395-2401
    • Ganley, B.1    Chowdhury, G.2    Bhansali, J.3    Daniels, J.S.4    Gates, K.S.5
  • 19
    • 84866844568 scopus 로고    scopus 로고
    • Cytotoxicity and genotoxicity of 1,4-bisdesoxyquinocetone, 3-methyl-quinoxaline-2-carboxylic acid (MQCA) in human hepatocytes
    • Zhang, K. et al. Cytotoxicity and genotoxicity of 1,4-bisdesoxyquinocetone, 3-methyl-quinoxaline-2-carboxylic acid (MQCA) in human hepatocytes. Res Vet Sci 93, 1393-1401 (2012).
    • (2012) Res Vet Sci , vol.93 , pp. 1393-1401
    • Zhang, K.1
  • 20
    • 84868518284 scopus 로고    scopus 로고
    • Genotoxicity evaluation of Mequindox in different short-term tests
    • Ihsan, A. et al. Genotoxicity evaluation of Mequindox in different short-term tests. Food Chem Toxicol 51, 330-336 (2013).
    • (2013) Food Chem Toxicol , vol.51 , pp. 330-336
    • Ihsan, A.1
  • 21
    • 79151474056 scopus 로고    scopus 로고
    • Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox
    • Wang, X. et al. Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox. Toxicology 280, 126-134 (2011).
    • (2011) Toxicology , vol.280 , pp. 126-134
    • Wang, X.1
  • 22
    • 34250196512 scopus 로고    scopus 로고
    • A quinoxaline 1,4-di-N-oxide derivative induces DNA oxidative damage not attenuated by Vitamin C and e treatment
    • Azqueta, A. et al. A quinoxaline 1,4-di-N-oxide derivative induces DNA oxidative damage not attenuated by vitamin C and E treatment. Chemico-biol Interact 168, 95-105 (2007).
    • (2007) Chemico-biol Interact , vol.168 , pp. 95-105
    • Azqueta, A.1
  • 23
    • 8844256506 scopus 로고    scopus 로고
    • Enzyme-activated, hypoxia-selective DNA damage by 3-amino-2 quinoxalinecarbonitrile 1,4-di-N-oxide
    • Chowdhury, G., Kotandeniya, D., Daniels, J. S., Barnes, C. L. & Gates, K. S. Enzyme-activated, hypoxia-selective DNA damage by 3-amino-2 quinoxalinecarbonitrile 1,4-di-N-oxide. Chem Res Toxicol 17, 1399-1405 (2004).
    • (2004) Chem Res Toxicol , vol.17 , pp. 1399-1405
    • Chowdhury, G.1    Kotandeniya, D.2    Daniels, J.S.3    Barnes, C.L.4    Gates, K.S.5
  • 24
    • 84955203011 scopus 로고    scopus 로고
    • Fumonisins: Oxidative stress-mediated toxicity and metabolism in vivo and in vitro
    • Wang, X. et al. Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro. Arch Toxicol, doi: 10.1007/s00204-00015-01604-00208 (2015).
    • (2015) Arch Toxicol
    • Wang, X.1
  • 25
    • 83955161129 scopus 로고    scopus 로고
    • Mequindox induced cellular DNA damage via generation of reactive oxygen species
    • Liu, J. et al. Mequindox induced cellular DNA damage via generation of reactive oxygen species. Mutat Res 741, 70-75 (2012).
    • (2012) Mutat Res , vol.741 , pp. 70-75
    • Liu, J.1
  • 26
    • 77952314460 scopus 로고    scopus 로고
    • ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro
    • Huang, X. J. et al. ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro. Chem-biol Interact 185, 227-234 (2010).
    • (2010) Chem-biol Interact , vol.185 , pp. 227-234
    • Huang, X.J.1
  • 27
    • 67349125456 scopus 로고    scopus 로고
    • Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells
    • Zou, J. et al. Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells. Mutat Res 676, 27-33 (2009).
    • (2009) Mutat Res , vol.676 , pp. 27-33
    • Zou, J.1
  • 28
    • 84957083238 scopus 로고    scopus 로고
    • High risk of adrenal toxicity of N1-desoxy quinoxaline 1,4-dioxide derivatives and the protection of oligomeric proanthocyanidins (OPC) in the inhibition of the expression of aldosterone synthetase in H295R cells
    • Wang, X. et al. High risk of adrenal toxicity of N1-desoxy quinoxaline 1,4-dioxide derivatives and the protection of oligomeric proanthocyanidins (OPC) in the inhibition of the expression of aldosterone synthetase in H295R cells. Toxicol 341-343, 1-16 (2016).
    • (2016) Toxicol , vol.341-343 , pp. 1-16
    • Wang, X.1
  • 29
    • 70449523001 scopus 로고    scopus 로고
    • Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats
    • Huang, X. J. et al. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Toxicol Lett 191, 167-173 (2009).
    • (2009) Toxicol Lett , vol.191 , pp. 167-173
    • Huang, X.J.1
  • 30
    • 84944572828 scopus 로고    scopus 로고
    • 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells
    • Gong, X., Ivanov, V. N. & Hei, T. K. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol 90, 2187-200 (2015).
    • (2015) Arch Toxicol , vol.90 , pp. 2187-2200
    • Gong, X.1    Ivanov, V.N.2    Hei, T.K.3
  • 31
    • 84947572294 scopus 로고    scopus 로고
    • Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways
    • Kim, H. G. et al. Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways. Arch Toxicol 89, 2039-2050 (2015).
    • (2015) Arch Toxicol , vol.89 , pp. 2039-2050
    • Kim, H.G.1
  • 32
    • 84947550702 scopus 로고    scopus 로고
    • Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite
    • Liao, Y. C., Chen, Y. F. & Lee, T. C. Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite. Arch Toxicol 89, 1971-1979 (2015).
    • (2015) Arch Toxicol , vol.89 , pp. 1971-1979
    • Liao, Y.C.1    Chen, Y.F.2    Lee, T.C.3
  • 33
    • 84940732505 scopus 로고    scopus 로고
    • Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation
    • Romanov, V., Whyard, T. C., Waltzer, W. C., Grollman, A. P. & Rosenquist, T. Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation. Arch Toxicol 89, 47-56 (2015).
    • (2015) Arch Toxicol , vol.89 , pp. 47-56
    • Romanov, V.1    Whyard, T.C.2    Waltzer, W.C.3    Grollman, A.P.4    Rosenquist, T.5
  • 34
    • 84977581842 scopus 로고    scopus 로고
    • The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo
    • Wang, X. et al. The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metab Rev 48, 159-182 (2016).
    • (2016) Drug Metab Rev , vol.48 , pp. 159-182
    • Wang, X.1
  • 35
    • 84928389176 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis
    • Watanabe, T., Sekine, S., Naguro, I., Sekine, Y. & Ichijo, H. Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis. J Biol Chem 290, 10791-10803 (2015).
    • (2015) J Biol Chem , vol.290 , pp. 10791-10803
    • Watanabe, T.1    Sekine, S.2    Naguro, I.3    Sekine, Y.4    Ichijo, H.5
  • 36
    • 84880287247 scopus 로고    scopus 로고
    • Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice
    • Ze, Y. et al. Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice. Chemosphere 92, 1183-1189 (2013).
    • (2013) Chemosphere , vol.92 , pp. 1183-1189
    • Ze, Y.1
  • 37
    • 0033984710 scopus 로고    scopus 로고
    • The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles
    • Paradies, G., Petrosillo, G., Pistolese, M. & Ruggiero, F. M. The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS lett 466, 323-326 (2000).
    • (2000) FEBS Lett , vol.466 , pp. 323-326
    • Paradies, G.1    Petrosillo, G.2    Pistolese, M.3    Ruggiero, F.M.4
  • 38
    • 36349030396 scopus 로고    scopus 로고
    • Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer
    • Kimura, M. et al. Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer. J Biol Chem 282, 33681-33690 (2007).
    • (2007) J Biol Chem , vol.282 , pp. 33681-33690
    • Kimura, M.1
  • 39
    • 14044254798 scopus 로고    scopus 로고
    • Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
    • Kobayashi, M. & Yamamoto, M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Sign 7, 385-394 (2005).
    • (2005) Antioxid Redox Sign , vol.7 , pp. 385-394
    • Kobayashi, M.1    Yamamoto, M.2
  • 40
    • 59849113546 scopus 로고    scopus 로고
    • Molecular mechanisms of Nrf2-mediated antioxidant response
    • Li, W. & Kong, A. N. Molecular mechanisms of Nrf2-mediated antioxidant response. Mole Carcinogen 48, 91-104 (2009).
    • (2009) Mole Carcinogen , vol.48 , pp. 91-104
    • Li, W.1    Kong, A.N.2
  • 41
    • 84868210978 scopus 로고    scopus 로고
    • Nrf2-keap1 system versus NF-kappaB: The good and the evil in chronic kidney disease?
    • Pedruzzi, L. M., Stockler-Pinto, M. B., Leite, M. & Mafra, D. Jr. Nrf2-keap1 system versus NF-kappaB: the good and the evil in chronic kidney disease? Biochimie 94, 2461-2466 (2012).
    • (2012) Biochimie , vol.94 , pp. 2461-2466
    • Pedruzzi, L.M.1    Stockler-Pinto, M.B.2    Leite, M.3    Mafra, D.4
  • 42
    • 84864375081 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 inhibits cell death in crotonaldehyde-stimulated HepG2 cells via the PKC-delta-p38-Nrf2 pathway
    • Lee, S. E. et al. Induction of heme oxygenase-1 inhibits cell death in crotonaldehyde-stimulated HepG2 cells via the PKC-delta-p38-Nrf2 pathway. Plos one 7, e41676 (2012).
    • (2012) Plos One , vol.7 , pp. e41676
    • Lee, S.E.1
  • 43
    • 84856905230 scopus 로고    scopus 로고
    • Apo-8′ -lycopenal induces expression of HO-1 and NQO-1 via the ERK/p38-Nrf2-ARE pathway in human HepG2 cells
    • Yang, C. M., Huang, S. M., Liu, C. L. & Hu, M. L. Apo-8′ -lycopenal induces expression of HO-1 and NQO-1 via the ERK/p38-Nrf2-ARE pathway in human HepG2 cells. J Agr Food Chem 60, 1576-1585 (2012).
    • (2012) J Agr Food Chem , vol.60 , pp. 1576-1585
    • Yang, C.M.1    Huang, S.M.2    Liu, C.L.3    Hu, M.L.4
  • 44
    • 84929708418 scopus 로고    scopus 로고
    • Reactive oxygen species-dependent JNK downregulated olaquindox-induced autophagy in HepG2 cells
    • Zhao, D. X. et al. Reactive oxygen species-dependent JNK downregulated olaquindox-induced autophagy in HepG2 cells. J Appl Toxicol 35, 709-716 (2015).
    • (2015) J Appl Toxicol , vol.35 , pp. 709-716
    • Zhao, D.X.1
  • 45
    • 84883231431 scopus 로고    scopus 로고
    • Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells
    • Zhao, W. X. et al. Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells. Cell Biol Toxicol 29, 229-238 (2013).
    • (2013) Cell Biol Toxicol , vol.29 , pp. 229-238
    • Zhao, W.X.1
  • 46
    • 84875608037 scopus 로고    scopus 로고
    • Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders
    • Yang, W. et al. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J Sci Food Agr 93, 1317-1325 (2013).
    • (2013) J Sci Food Agr , vol.93 , pp. 1317-1325
    • Yang, W.1
  • 47
    • 84878903945 scopus 로고    scopus 로고
    • Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone
    • Yu, M. et al. Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone. Regul Toxicol Pharm 66, 279-285 (2013).
    • (2013) Regul Toxicol Pharm , vol.66 , pp. 279-285
    • Yu, M.1
  • 48
    • 84962429341 scopus 로고    scopus 로고
    • Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells
    • Wang, X. et al. Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells. Toxicology 350-352, 1-14 (2016).
    • (2016) Toxicology , vol.350-352 , pp. 1-14
    • Wang, X.1
  • 49
    • 79952069102 scopus 로고    scopus 로고
    • A chronic toxicity study of cyadox in Wistar rats
    • Wang, X. et al. A chronic toxicity study of cyadox in Wistar rats. Regul. Toxicol. Phar. 59, 324-333 (2011).
    • (2011) Regul. Toxicol. Phar. , vol.59 , pp. 324-333
    • Wang, X.1
  • 50
    • 79952069722 scopus 로고    scopus 로고
    • Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats
    • Wang, X. et al. Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats. Regul Toxicol Phar 58, 421-427 (2010).
    • (2010) Regul Toxicol Phar , vol.58 , pp. 421-427
    • Wang, X.1
  • 51
    • 84939782104 scopus 로고    scopus 로고
    • Mechanism of adrenocortical toxicity induced by quinocetone and its bidesoxy quinocetone metabolite in porcine adrenocortical cells in vitro
    • Wang, X. et al. Mechanism of adrenocortical toxicity induced by quinocetone and its bidesoxy quinocetone metabolite in porcine adrenocortical cells in vitro. Food Chem Toxicol 84, 115-124 (2015).
    • (2015) Food Chem Toxicol , vol.84 , pp. 115-124
    • Wang, X.1
  • 52
    • 84912028642 scopus 로고    scopus 로고
    • Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites
    • Zhang, K. et al. Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites. Cell Biol Toxicol 30, 313-329 (2014).
    • (2014) Cell Biol Toxicol , vol.30 , pp. 313-329
    • Zhang, K.1
  • 53
    • 84940485315 scopus 로고    scopus 로고
    • Curcumin attenuates quinocetone-induced oxidative stress and genotoxicity in human hepatocyte L02 cells
    • Dai, C., Tang, S., Li, D., Zhao, K. & Xiao, X. Curcumin attenuates quinocetone-induced oxidative stress and genotoxicity in human hepatocyte L02 cells. Toxicol Mech Method 25, 340-346 (2015).
    • (2015) Toxicol Mech Method , vol.25 , pp. 340-346
    • Dai, C.1    Tang, S.2    Li, D.3    Zhao, K.4    Xiao, X.5
  • 54
    • 85003050775 scopus 로고    scopus 로고
    • Research on olaquindox induced endoplasmic reticulum stress related apoptosis on nephrotoxicity
    • Li, Z. et al. Research on olaquindox induced endoplasmic reticulum stress related apoptosis on nephrotoxicity. J Hygi Res 44, 444-450 (2015).
    • (2015) J Hygi Res , vol.44 , pp. 444-450
    • Li, Z.1
  • 55
    • 84887330660 scopus 로고    scopus 로고
    • TNFR1/TNF-alpha and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells
    • Zhang, C. M. et al. TNFR1/TNF-alpha and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells. Food Chem Toxicol 62, 825-838 (2013).
    • (2013) Food Chem Toxicol , vol.62 , pp. 825-838
    • Zhang, C.M.1
  • 56
    • 79959792150 scopus 로고    scopus 로고
    • C-Myc influences olaquindox-induced apoptosis in human hepatoma G2 cells
    • Zhang, T. et al. c-Myc influences olaquindox-induced apoptosis in human hepatoma G2 cells. Mol Cell Biochem 354, 253-261 (2011).
    • (2011) Mol Cell Biochem , vol.354 , pp. 253-261
    • Zhang, T.1
  • 57
    • 79957808725 scopus 로고    scopus 로고
    • Olaquindox induces apoptosis through the mitochondrial pathway in HepG2 cells
    • Zou, J. et al. Olaquindox induces apoptosis through the mitochondrial pathway in HepG2 cells. Toxicol 285, 104-113 (2011).
    • (2011) Toxicol , vol.285 , pp. 104-113
    • Zou, J.1
  • 58
    • 77955925808 scopus 로고    scopus 로고
    • Interactions of NADPH oxidase, renin-angiotensin-aldosterone system and reactive oxygen species in mequindoxmediated aldosterone secretion in Wistar rats
    • Huang, X. J. et al. Interactions of NADPH oxidase, renin-angiotensin-aldosterone system and reactive oxygen species in mequindoxmediated aldosterone secretion in Wistar rats. Toxicol Lett 198, 112-118 (2010).
    • (2010) Toxicol Lett , vol.198 , pp. 112-118
    • Huang, X.J.1
  • 59
    • 84899922708 scopus 로고    scopus 로고
    • Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats
    • Yu, M. et al. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats. Food Chem Toxicol 69, 210-219 (2014).
    • (2014) Food Chem Toxicol , vol.69 , pp. 210-219
    • Yu, M.1
  • 60
    • 78951491598 scopus 로고    scopus 로고
    • Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice
    • Wang, D. et al. Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice. Food Chem Toxicol 49, 477-484 (2011).
    • (2011) Food Chem Toxicol , vol.49 , pp. 477-484
    • Wang, D.1
  • 61
    • 80655138713 scopus 로고    scopus 로고
    • Dynamic metabolic response of mice to acute mequindox exposure
    • Res
    • Zhao, X. J. et al. Dynamic metabolic response of mice to acute mequindox exposure. J Proteome 10, Res, 5183-5190 (2011).
    • (2011) J Proteome , vol.10 , pp. 5183-5190
    • Zhao, X.J.1
  • 62
    • 77949602182 scopus 로고    scopus 로고
    • Metabolism of mequindox in liver microsomes of rats, chicken and pigs
    • Liu, Z. Y., Huang, L. L., Chen, D. M. & Yuan, Z. H. Metabolism of mequindox in liver microsomes of rats, chicken and pigs. Rapid Commun Mass 24, 909-918 (2010).
    • (2010) Rapid Commun Mass , vol.24 , pp. 909-918
    • Liu, Z.Y.1    Huang, L.L.2    Chen, D.M.3    Yuan, Z.H.4
  • 63
    • 61749095311 scopus 로고    scopus 로고
    • Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: Mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide
    • Junnotula, V., Sarkar, U., Sinha, S. & Gates, K. S. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide. J Am Chem Soc 131, 1015-1024 (2009).
    • (2009) J Am Chem Soc , vol.131 , pp. 1015-1024
    • Junnotula, V.1    Sarkar, U.2    Sinha, S.3    Gates, K.S.4
  • 64
    • 10744225770 scopus 로고    scopus 로고
    • Photochemical electron transfer reactions of tirapazamine
    • Poole, J. S. et al. Photochemical electron transfer reactions of tirapazamine. J Photoch Photobio 75, 339-345 (2002).
    • (2002) J Photoch Photobio , vol.75 , pp. 339-345
    • Poole, J.S.1
  • 65
    • 78149432961 scopus 로고    scopus 로고
    • Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21
    • El-Khatib, M., Geara, F., Haddadin, M. J. & Gali-Muhtasib, H. Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21. Radiat Oncol, doi: 10.1186/1748-717X-5-107 (2010).
    • (2010) Radiat Oncol
    • El-Khatib, M.1    Geara, F.2    Haddadin, M.J.3    Gali-Muhtasib, H.4
  • 66
    • 84929307882 scopus 로고    scopus 로고
    • Antioxidant enzymes as redox-based biomarkers: A brief review
    • Yang, H. Y. & Lee, T. H. Antioxidant enzymes as redox-based biomarkers: a brief review. BMB Rep 48, 200-208 (2015).
    • (2015) BMB Rep , vol.48 , pp. 200-208
    • Yang, H.Y.1    Lee, T.H.2
  • 67
    • 84925536048 scopus 로고    scopus 로고
    • Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation
    • Shi, J. et al. Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation. Tumour Biol 36, 655-662 (2015).
    • (2015) Tumour Biol , vol.36 , pp. 655-662
    • Shi, J.1
  • 68
    • 84890301350 scopus 로고    scopus 로고
    • The metabolism of carbadox, olaquindox, mequindox, quinocetone and cyadox: An overview
    • Liu, Z. Y. & Sun, Z. L. The metabolism of carbadox, olaquindox, mequindox, quinocetone and cyadox: an overview. J Med Chem 9, 1017-1027 (2013).
    • (2013) J Med Chem , vol.9 , pp. 1017-1027
    • Liu, Z.Y.1    Sun, Z.L.2
  • 69
    • 77649237309 scopus 로고    scopus 로고
    • NF-kappaB and cancer: How intimate is this relationship
    • Prasad, S., Ravindran, J. & Aggarwal, B. B. NF-kappaB and cancer: how intimate is this relationship. Mol Cell Biochem 336, 25-37 (2010).
    • (2010) Mol Cell Biochem , vol.336 , pp. 25-37
    • Prasad, S.1    Ravindran, J.2    Aggarwal, B.B.3
  • 70
    • 84884489334 scopus 로고    scopus 로고
    • Renal injury and Nrf2 modulation in mouse kidney following chronic exposure to TiO(2) nanoparticles
    • Gui, S. et al. Renal injury and Nrf2 modulation in mouse kidney following chronic exposure to TiO(2) nanoparticles. J Agri Food Chem 61, 8959-8968 (2013).
    • (2013) J Agri Food Chem , vol.61 , pp. 8959-8968
    • Gui, S.1
  • 71
    • 84943595860 scopus 로고    scopus 로고
    • Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice
    • Luo, L. et al. Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice. Toxicol Appl Pharm 288, 339-348 (2015).
    • (2015) Toxicol Appl Pharm , vol.288 , pp. 339-348
    • Luo, L.1
  • 73
    • 84943542139 scopus 로고    scopus 로고
    • Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells
    • Yang, Y. et al. Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells. Environ Toxicol Pha 40, 792-799 (2015).
    • (2015) Environ Toxicol Pha , vol.40 , pp. 792-799
    • Yang, Y.1
  • 74
    • 84988735048 scopus 로고    scopus 로고
    • Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: Role of glutathione transferase P1-1 and aldose reductase
    • Sánchez-Gómez, F. J. et al. Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase. Front Pharmacol 7, 237 (2016).
    • (2016) Front Pharmacol , vol.7 , pp. 237
    • Sánchez-Gómez, F.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.