C-Myc influences olaquindox-induced apoptosis in human hepatoma G2 cells

Molecular and Cellular Biochemistry

Volumn 354, Issue 1-2, 2011, Pages 253-261

  Zhang, Ting ^a   Tang, Shu Sheng ^a   Jin, Xi ^a,b   Liu, Feng Ying ^a   Zhang, Chao Ming ^a   Zhao, Wen Xia ^a   Zhang, Shen ^a   Sun, Chun Di ^a   Xiao, Xi Long ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; c Myc; Cytochrome c; HepG2 cells; Olaquindox; ROS

Indexed keywords

CYTOCHROME C; MYC PROTEIN; OLAQUINDOX; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME RELEASE; HEPATOMA CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SILENCER ELEMENT; VECTOR CONTROL;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; GROWTH SUBSTANCES; HUMANS; PROTO-ONCOGENE PROTEINS C-MYC; QUINOXALINES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 79959792150     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0825-2     Document Type: Article

References (37)

1. Zou J, Chen Q, Tang S, Jin X, Chen K, Zhang T, Xiao X (2009) Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells. Mutat Res Genet Toxicol Environ Mutagen 676(1-2):27-33
2. Chen Q (2009) Study on the effect of oxidative damage and mechanism of S phase block induced by quinoxalines. Dissertation, China Agricultural University
3. Klefstrom J, Verschuren E, Evan G (2002) c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. J Biol Chem 277(45):43224-43232 (Pubitemid 35285708)
4. Askew DS, Ashmun RA, Simmons BC, Cleveland JL (1991) Constitutive c-myc expression in an IL-3-dependent myeloid cellline suppresses cell-cycle arrest and accelerates apoptosis. Oncogene 6(10):1915-1922 (Pubitemid 21924028)
5. Evan G, Wyllie A, Gilbert C, Littlewood T, Land H, Brooks M, Waters C, Penn L, Hancock D (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69(1):119-128
6. Dang CV, Resar L, Emison E, Kim S, Li Q, Prescott JE, Wonsey D, Zeller K (1999) Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253(1):63-77
7. Harrington E, Fanidi A, Evan G (1994) Oncogenes and cell death. Curr Opin Genet Dev 4(1):120-129 (Pubitemid 24060305)
8. Evan G, Brown L, Whyte M, Harrington E (1995) Apoptosis and the cell cycle. Curr Opin Cell Biol 7(6):825-834
9. Packham G, Cleveland JL (1995) c-Myc and apoptosis. Biochim Biophys Acta Rev Cancer 1242(1):11-28
10. Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F (2006) The c-Myc target gene network. Semin Cancer Biol 16(4):253-264 (Pubitemid 44311039)
11. Meyer N, Kim SS, Penn LZ (2006) The Oscar-worthy role of Myc in apoptosis. Semin Cancer Biol 16(4):275-287 (Pubitemid 44321974)
12. Hydbring P, Larsson LG (2010) Cdk2: a key regulator of the senescence control function of Myc. Aging 2(4):244-250
13. Prendergast G (1999) Mechanisms of apoptosis by c-Myc. Oncogene 18(19):2967-2987
14. Cherney B, Bhatia K, Tosato G (1994) A role for deregulated c-Myc expression in apoptosis of Epstein-Barr virus-immortalized B cells. Proc Natl Acad Sci USA 91(26):12967-12971
15. Klefstrom J, Vastrik I, Saksela E, Valle J, Eilers M, Alitalo K (1994) c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. EMBO J 13(22):5442-5450 (Pubitemid 24351823)
16. Juin P, Hueber A, Littlewood T, Evan G (1999) c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev 13(11):1367-1381 (Pubitemid 29270243)
17. Tanaka H, Matsumura I, Ezoe S, Satoh Y, Sakamaki T, Albanese C, Machii T, Pestell R, Kanakura Y (2002) E2F1 and c-Myc potentiate apoptosis through inhibition of NF-[kappa] B activity that facilitates MnSOD-mediated ROS elimination. Mol Cell 9(5):1017-1029
18. Vafa O, Wade M, Kern S, Beeche M, Pandita T, Hampton G, Wahl G (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 9(5):1031-1044 (Pubitemid 34626672)
19. Pan J, Hong M, Ren J (2009) Reactive oxygen species: a doubleedged sword in oncogenesis. World J Gastroenterol WJG 15(14):1702-1707
20. Chen Y, Jungsuwadee P, Vore M, Butterfield DA, St Clair DK (2007) Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol Interv 7(3):147-156
21. Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RAJ, Kinzler KW, Vogelstein B (2001) Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med 7(10):1111-1117 (Pubitemid 33010018)
22. Grassilli E, Ballabeni A, Maellaro E, Del Bello B, Helin K (2004) Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. J Biol Chem 279(20):21318-21326 (Pubitemid 38656539)
23. Soucie E, Annis M, Sedivy J, Filmus J, Leber B, Andrews D, Penn L (2001) Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Mol Cell Biol 21(14):4725-4736 (Pubitemid 32588253)
24. Wang Y, Liu S, Zhang G, Zhou C, Zhu H, Zhou X, Quan L, Bai J, Xu N (2005) Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo. Breast Cancer Res 7(2):R220-R228
25. Voogd CE, Vanderstel JJ, Jacobs J (1980) The mutagenic action of quindoxin, carbadox, olaquindox and some other N-oxides on bacteria and yeast. Mutat Res 78(3):233-242 (Pubitemid 10064517)
26. Beutin L, Preller E, Kowalski B (1981) Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-Noxides. Antimicrob Agents Chemother 20(3):336-343 (Pubitemid 12225710)
27. Yoshimura H, Nakamura M, Koeda T, Yoshikawa K (1981) Mutagenicities of carbadox and olaquindox-growth promoters for pigs. Mutat Res 90(1):49-55 (Pubitemid 11048348)
28. Nunoshiba T, Nishioka H (1989) Genotoxicity of quinoxaline 1,4-dioxide derivatives in Escherichia coli and Salmonella typhimurium. Mutat Res DNA Repair 217(3):203-209 (Pubitemid 19131672)
29. Hao L, Chen Q, Xiao X (2006) Molecular mechanism of mutagenesis induced by olaquindox using a shuttle vector pSP189/ mammalian cell system. Mutat Res Fundam Mol Mech Mutagen 599(1-2):21-25 (Pubitemid 44041503)
30. Chen Q, Tang S, Jin X, Zou J, Chen K, Zhang T, Xiao X (2009) Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem Toxicol 47(2):328-334
31. Novave KL, Semenkova L, Holik M (1986) Deoxidation of quinoxaline-1,4-dioxide derivative in the presence of aminoacids. CeskFarm 35:145-150 (Pubitemid 16088876)
32. Thompson E (1998) The many roles of c-Myc in apoptosis. Annu Rev Physiol 60(1):575-600
33. Nilsson J, Cleveland J (2003) Myc pathways provoking cell suicide and cancer. Oncogene 22(56):9007-9021 (Pubitemid 38121701)
34. Ceballos E, Muňoz-Alonso M, Berwanger B, Acosta J, Hernández R, Krause M, Hartmann O, Eilers M, Leon J (2005) Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes. Oncogene 24(28): 4559-4571
35. Park J, Chung Y, Kang S, Kim J, Kim Y, Kim H, Kim Y, Kim J, Yoo Y (2002) c-Myc exerts a protective function through ornithine decarboxylase against cellular insults. Mol Pharmacol 62(6):1400-1408 (Pubitemid 35403835)
36. Manna S, Zhang H, Yan T, Oberley L, Aggarwal B (1998) Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1. J Biol Chem 273(21):13245-13254 (Pubitemid 28246897)
37. Chowdhury R, Chowdhury S, Roychoudhury P, Mandal C, Chaudhuri K (2009) Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Apoptosis 14(1):108-123