Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells

Toxicology

Volumn 350-352, Issue , 2016, Pages 1-14

  Wang, Xu ^a   Bai, Yijie ^a   Cheng, Guyue ^a   Ihsan, Awais ^c   Zhu, Feng ^a   Wang, Yulian ^a   Tao, Yanfei ^b   Chen, Dongmei ^b   Dai, Menghong ^b   Liu, Zhengli ^b   Yuan, Zonghui ^a,b  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b Hubei Collaborative Innovation Centre for Animal Nutrition and Feed Safety   (China)

^c COMSATS Institute of Information Technology ^*  (Pakistan)

Author keywords

Adrenal; Aldosterone; Genomics; NCI H295R cells; Proteomics; Quinocetone

Indexed keywords

ALDOSTERONE; ANTIINFECTIVE AGENT; CYTOCHROME P450 17; CYTOCHROME P450 17A1; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GROWTH PROMOTOR; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN KINASE C; QUINOXALINE 1,4 DIOXIDE; UNCLASSIFIED DRUG; CYP17A1 PROTEIN, HUMAN; QUINOCETONE; QUINOXALINE DERIVATIVE; STEROID 17ALPHA MONOOXYGENASE;

ADRENAL CORTEX CELL; ALDOSTERONE RELEASE; APOPTOSIS; ARTICLE; CELLULAR STRESS RESPONSE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; GENOMICS; HORMONE DETERMINATION; HORMONE INHIBITION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLISM; MICROARRAY ANALYSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; TOXICITY TESTING; ADRENAL CORTEX; ADRENAL CORTEX TUMOR; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; PROCEDURES; SECRETION (PROCESS); TUMOR CELL LINE;

ADRENAL CORTEX; ADRENAL CORTEX NEOPLASMS; ALDOSTERONE; APOPTOSIS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; MASS SPECTROMETRY; MICROARRAY ANALYSIS; OXIDATIVE STRESS; PROTEOMICS; QUINOXALINES; SIGNAL TRANSDUCTION; STEROID 17-ALPHA-HYDROXYLASE;

EID: 84962429341     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2016.03.005     Document Type: Article

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