Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 69, Issue , 2014, Pages 210-219

  Yu, Miao ^a   Wang, Di ^a   Xu, Mengjing ^a   Liu, Yang ^a   Wang, Xia ^a   Liu, Jun ^a   Yang, Xuefeng ^a   Yao, Ping ^a   Yan, Hong ^a   Liu, Liegang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Nrf2 HO 1 pathway; Oxidative stress; Quinocetone

Indexed keywords

HEME OXYGENASE 1; QUINOCETONE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VETERINARY DRUG; 8-OXO-7-HYDRODEOXYGUANOSINE; ANTIOXIDANT; DEOXYGUANOSINE; NFE2L2 PROTEIN, RAT; QUINOXALINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL REGENERATION; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG DOSE COMPARISON; INFLAMMATION; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BODY WEIGHT; DRUG EFFECTS; GENETICS; LIVER; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; URINE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BODY WEIGHT; DEOXYGUANOSINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME OXYGENASE-1; HEPATOCYTES; LIVER; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; QUINOXALINES; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84899922708     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.04.026     Document Type: Article

References (36)

1. Azqueta A., Arbillaga L., Pachon G., Cascante M., Creppy E.E., Lopez de Cerain A. A quinoxaline 1,4-di-N-oxide derivative induces DNA oxidative damage not attenuated by vitamin C and E treatment. Chem. Biol. Interact. 2007, 168:95-105.
2. Carta A., Corona P., Loriga M. Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities. Curr. Med. Chem. 2005, 12:2259-2272.
3. Carter W.O., Narayanan P.K., Robinson J.P. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J. Leukoc. Biol. 1994, 55:253-258.
4. Chen Q., Tang S., Jin X., Zou J., Chen K., Zhang T., Xiao X. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem. Toxicol. 2009, 47:328-334.
5. Chen W., Wang H., Tao S., Zheng Y., Wu W., Lian F., Jaramillo M., Fang D., Zhang D.D. Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell Cycle (Georgetown, Tex.) 2013, 12:2321-2328.
6. Chen Z., Wang Y., Ba T., Li Y., Pu J., Chen T., Song Y., Gu Y., Qian Q., Yang J., Jia G. Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro. Toxicol. Lett. 2014.
7. da Silva J.L., Morishita T., Escalante B., Staudinger R., Drummond G., Goligorsky M.S., Lutton J.D., Abraham N.G. Dual role of heme oxygenase in epithelial cell injury: contrasting effects of short-term and long-term exposure to oxidant stress. J. Lab. Clin. Med. 1996, 128:290-296.
8. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., Yamamoto M., Talalay P. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. USA 2002, 99:11908-11913.
9. Galbraith, R., 1999. Heme oxygenase: who needs it? Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 222, 299-305.
10. Hellman B., Vaghef H., Bostrom B. The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay. Mutat. Res. 1995, 336:123-131.
11. Huang X.-J., Zhang H.-H., Wang X., Huang L.-L., Zhang L.-Y., Yan C.-X., Liu Y., Yuan Z.-H. ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro. Chem.-Biol. Interact. 2010, 185:227-234.
12. Jin X., Chen Q., Tang S.S., Zou J.J., Chen K.P., Zhang T., Xiao X.L. Investigation of quinocetone-induced genotoxicity in HepG2 cells using the comet assay, cytokinesis-block micronucleus test and RAPD analysis. Toxicol. In Vitro 2009, 23:1209-1214.
13. Li W., Kong A.N. Molecular mechanisms of Nrf2-mediated antioxidant response. Mol. Carcinogenesis 2009, 48:91-104.
14. Lirk P., Hoffmann G., Rieder J. Inducible nitric oxide synthase-time for reappraisal. Current drug targets. Inflamm. Aller. 2002, 1:89-108.
15. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego, Calif.) 2001, 25:402-408.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
17. Moinova H.R., Mulcahy R.T. Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element. Biochem. Biophys. Res. Commun. 1999, 261:661-668.
18. Motohashi H., Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 2004, 10:549-557.
19. Nesslany F., Zennouche N., Simar-Meintieres S., Talahari I., Nkili-Mboui E.N., Marzin D. In vivo Comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds. Mutat. Res. 2007, 630:28-41.
20. Poss K.D., Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc. Natl. Acad. Sci. USA 1997, 94:10925-10930.
21. Prasad S., Ravindran J., Aggarwal B.B. NF-kappaB and cancer: how intimate is this relationship. Mol. Cell. Biochem. 2010, 336:25-37.
22. Sasaki Y.F., Nishidate E., Izumiyama F., Matsusaka N., Tsuda S. Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutat. Res. 1997, 391:215-231.
23. Sermeus A., Rebucci M., Fransolet M., Flamant L., Desmet D., Delaive E., Arnould T., Michiels C. Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types. J. Cell. Physiol. 2013, 228:2365-2376.
24. Shen J., Yang C., Wu C., Feng P., Wang Z., Li Y., Zhang S. Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24:375-383.
25. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
26. Song F., Chen W., Jia W., Yao P., Nussler A.K., Sun X., Liu L. A natural sweetener, Momordica grosvenori, attenuates the imbalance of cellular immune functions in alloxan-induced diabetic mice. Phytother. Res.: PTR 2006, 20:552-560.
27. Valavanidis A., Vlachogianni T., Fiotakis C. 8-Hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health. Part C, Environ. Carcinogenesis Ecotoxicol. Rev. 2009, 27:120-139.
28. Wang X., Zhang W., Wang Y., Peng D., Ihsan A., Huang X., Huang L., Liu Z., Dai M., Zhou W., Yuan Z.H. Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats. Regul. Toxicol. Pharmacol. 2010, 58:421-427.
29. Wang D., Zhong Y., Luo X.A., Wu S.A., Xiao R., Bao W., Yang W., Yan H., Yao P., Liu L.G. Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice. Food Chem. Toxicol. 2011, 49:477-484.
30. Wang X., He Q.H., Wang Y.L., Ihsan A., Huang L.L., Zhou W., Su S.J., Liu Z.L., Yuan Z.H. A chronic toxicity study of cyadox in Wistar rats. Regul. Toxicol. Pharmacol. 2011, 59:324-333.
31. Wang D., Luo X., Zhong Y., Yang W., Xu M., Liu Y., Meng J., Yao P., Yan H., Liu L. Pu-erh black tea extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague-Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure. Food Chem. Toxicol. 2012, 50:147-154.
32. Wang X., Zhang W., Wang Y.L., Ihsan A., Dai M.H., Huang L.L., Chen D.M., Tao Y.F., Peng D.P., Liu Z.L., Yuan Z.H. Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats. Food Chem. Toxicol. 2012, 1600-1609.
33. Yang W., Fu J., Xiao X., Yan H., Bao W., Wang D., Hao L., Nussler A.K., Yao P., Liu L. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J. Sci. Food Agric. 2012, 93:1317-1325.
34. Yu M., Xu M., Liu Y., Yang W., Rong Y., Yao P., Yan H., Wang D., Liu L. Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone. Regul. Toxicol. Pharmacol. 2013, 66:279-285.
35. Yun N., Eum H.A., Lee S.M. Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats. Antioxid. Redox Signal. 2010, 13:1503-1512.
36. Zhou B.B., Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 2000, 408:433-439.