High risk of adrenal toxicity of N1-desoxy quinoxaline 1,4-dioxide derivatives and the protection of oligomeric proanthocyanidins (OPC) in the inhibition of the expression of aldosterone synthetase in H295R cells

Toxicology

Volumn 341-343, Issue , 2016, Pages 1-16

  Wang, Xu ^a   Yang, Chunhui ^a   Ihsan, Awais ^c   Luo, Xun ^b   Guo, Pu ^b   Cheng, Guyue ^b   Dai, Menghong ^a   Chen, Dongmei ^b   Liu, Zhenli ^b   Yuan, Zonghui ^a,b  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety   (China)

^c Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety ^*  (Pakistan)

Author keywords

Adrenal toxicity; Aldosterone; Cyadox; H295R cells; Mequindox; Quinocetone; Quinoxaline

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 1; ALDOSTERONE; ALDOSTERONE SYNTHASE; CIADOX; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYP11B1 PROTEIN; MEQUINDOX; MESSENGER RNA; NUCLEAR RECEPTOR NUR77; NUCLEAR RECEPTOR RELATED FACTOR 1; PROANTHOCYANIDIN DERIVATIVE; QUINOCETONE; QUINOXALINE DERIVATIVE; STEROIDOGENIC FACTOR 1; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; ANTIOXIDANT; PROANTHOCYANIDIN; QUINDOXIN; STEROID 11BETA MONOOXYGENASE;

ADRENAL CELL; ADRENAL DISEASE; ADRENAL TOXICITY; ARTICLE; CELL DAMAGE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BIOTRANSFORMATION; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; METABOLISM;

ADRENAL GLAND DISEASES; ALDOSTERONE; ANTIOXIDANTS; BIOTRANSFORMATION; CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 CYP11B2; HUMANS; OXIDATIVE STRESS; PROANTHOCYANIDINS; QUINOXALINES; RNA, MESSENGER; STEROID 11-BETA-HYDROXYLASE;

EID: 84957083238     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2016.01.005     Document Type: Article

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