Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and compared with its metabolites

Environmental Toxicology and Pharmacology

Volumn 39, Issue 2, 2015, Pages 555-567

  Zhang, Keyu ^a   Wang, Xiaoyang ^a   Wang, Chunmei ^a   Zheng, Haihong ^a   Li, Tao ^a   Xiao, Sui ^a   Wang, Mi ^a   Fei, Chenzhong ^a   Zhang, Lifang ^a   Xue, Feiqun ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

1,4 Bisdesoxyquinocetone; 3 Methylquinoxaline 2 carboxylic acid; Apoptosis; Genotoxicity; Mitochondrial damage; Quinocetone

Indexed keywords

1,4 BISDESOXYQUINOCETONE; 3 METHYLQUINOXALINE 2 CARBOXYLIC ACID; CASPASE; DRUG METABOLITE; QUINOCETONE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CELL CYCLE PROTEIN; MESSENGER RNA;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DAMAGE; CELL VIABILITY; CHROMOSOME BREAKAGE; CHROMOSOME LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; CYTOKINESIS BLOCK MICRONUCLEUS TEST; CYTOTOXICITY; DNA FINGERPRINTING; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENOMICS; GENOTOXICITY; GROWTH INHIBITION; HEPG2 CELL LINE; HOMEOSTASIS; HORMESIS; HUMAN; HUMAN CELL; METABOLITE; MICRONUCLEUS; MICRONUCLEUS TEST; MITOCHONDRIAL DAMAGE; MITOCHONDRIAL DYNAMICS; MTT ASSAY; OXIDATION REDUCTION REACTION; RANDOM AMPLIFIED POLYMORPHIC DNA; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY;

ANIMALIA;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE PROTEINS; HEP G2 CELLS; HUMANS; MICRONUCLEUS TESTS; MITOCHONDRIA; OXIDATION-REDUCTION; QUINOXALINES; RNA, MESSENGER;

EID: 84922523115     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2015.01.017     Document Type: Article

References (39)

1. Atienzar F.A., Jha A.N. The random amplified polymorphic DNA (RAPD) assay and related techniques applied to genotoxicity and carcinogenesis studies: a critical review. Mutat. Res. 2006, 613:76-102.
2. Beutin L., Preller E., Kowalski B. Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides. Antimicrob. Agents Chemother. 1981, 20:336-343.
3. Brentnall M., Rodriguez-Menocal L., De Guevara R.L., Cepero E., Boise L.H. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 2013, 14:32.
4. Calabrese E.J., Blain R. The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview. Toxicol. Appl. Pharmacol. 2005, 202:289-301.
5. Caminada D., Escher C., Fent K. Cytotoxicity of pharmaceuticals found in aquatic systems: comparison of PLHC-1 and RTG-2 fish cell lines. Aquat. Toxicol. 2006, 79:114-123.
6. Carta A., Corona P., Loriga M. Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities. Curr. Med. Chem. 2005, 12:2259-2272.
7. Cedergreen N., Kudsk P., Mathiassen S.K., Sorensen H., Streibig J.C. Reproducibility of binary-mixture toxicity studies. Environ. Toxicol. Chem. 2007, 26:149-156.
8. Chen Q., Tang S., Jin X., Zou J., Chen K., Zhang T., Xiao X. Investigation of the genotoxicity of quinocetone, carbadox and olaquindoxin vitro using Vero cells. Food Chem. Toxicol. 2009, 47:328-334.
9. Chien C.W., Ho I.C., Lee T.C. Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells. Carcinogenesis 2009, 30:1813-1820.
10. Cuevas-Córdoba B., Santiago-García J. Saliva: a fluid of study for OMICS. OMICS 2014, 18(2):87-97.
11. Ehrlich V., Darroudi F., Uhl M., Steinkellner H., Gann M., Majer B.J., Eisenbauer M., Knasmüller S. Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells. Food Chem. Toxicol. 2002, 40:1085-1090.
12. Hassett C., Aicher L., Sidhu J.S., Omiecinski C.J. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum. Mol. Genet. 1994, 3:421-428.
13. Huang L., Xiao A., Fan S., Yin J., Chen P., Liu D., Qiu Y., Wang Y., Yuan Z. Development of liquid chromatographic methods for determination of quinocetone and its main metabolites in edible tissues of swine and chicken. J. AOAC Int. 2005, 88:472-478.
14. Huang X.J., Ihsan A., Wang X., Dai M.H., Wang Y.L., Su S.J., Xue X.J., Yuan Z.H. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Toxicol. Lett. 2009, 191:167-173.
15. Ihsan A., Wang X., Zhang W., Tu H., Wang Y., Huang L., Iqbal Z., Cheng G., Pan Y., Liu Z., Tan Z., Zhang Y., Yuan Z. Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo. Food Chem. Toxicol. 2013, 59:207-214.
16. Jin X., Chen Q., Tang S.S., Zou J.J., Chen K.P., Zhang T., Xiao X.L. Investigation of quinocetone-induced genotoxicity in HepG2 cells using the comet assay, cytokinesis-block micronucleus test and RAPD analysis. Toxicol. In Vitro 2009, 23:1209-1214.
17. Kantari C., Walczak H. Caspase-8 and bid: caught in the act between death receptors and mitochondria. Biochim. Biophys. Acta 2011, 1813:558-563.
18. Knasmüller S., Mersch-Sundermann V., Kevekordes S., Darroudi F., Huber W.W., Hoelzl C., Bichler J., Majer B.J. Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 2004, 198:315-328.
19. Kumar S. Caspase function in programmed cell death. Cell Death Differ. 2007, 14:32-43.
20. Lee J.A., Park J.E., Lee D.H., Park S.G., Myung P.K., Park B.C., Cho S. G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1. Oncogene 2008, 27:1297-1305.
21. Livingstone D.R. Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. Mar. Pollut. Bull. 2001, 42:656-666.
22. Nakayama K., Nakayama N., Wang T.L., Shih IeM. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. Cancer Res. 2007, 67:8058-8064.
23. Nunoshiba T., Nishioka H. Genotoxicity of quinoxaline 1,4-dioxide derivatives in Escherichia coli and Salmonella typhimurium. Mutat. Res. 1989, 217:203-209.
24. Pedersen P.L. The cancer cell's power plants as promising therapeutic targets: an overview. J. Bioenerg. Biomembr. 2007, 39:1-12.
25. Scolastici C., Alves de Lima R.O., Barbisan L.F., Ferreira A.L.A., Ribeiro D.A., Salvadori D.M.F. Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test. Toxicol. In Vitro 2008, 22:510-514.
26. Steiner S., Anderson N.L. Expression profiling in toxicology - potentials and limitations. Toxicol. Lett. 2000, 112-113:467-471.
27. Tahir R.A., Sehgal S.A., Khattak N.A., Khan, Khattak J.Z., Mir A. Tumor necrosis factor receptor superfamily 10B (TNFRSF10B): an insight from structure modeling to virtual screening for designing drug against head and neck cancer. Theor. Biol. Med. Model. 2013, 10:38.
28. Tasanen K., Parkkonen T., Chow L.T., Kivirikko K.I., Pihlajaniemi T. Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase. J. Biol. Chem. 1988, 263:16218-16224.
29. Wang D., Luo X., Zhong Y., Yang W., Xu M., Liu Y., Meng J., Yao P., Yan H., Liu L. Pu-erh black tea extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague-Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure. Food Chem. Toxicol. 2012, 50:147-154.
30. Wang X., Zhang W., Wang Y., Peng D., Ihsan A., Huang X., Huang L., Liu Z., Dai M., Zhou W., Yuan Z.H. Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats. Regul. Toxicol. Pharmacol. 2010, 58:421-427.
31. Wang X., Zhang W., Wang Y.L., Ihsan A., Dai M.H., Huang L.L., Chen D.M., Tao Y.F., Peng D.P., Liu Z.L., Yuan Z.H. Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats. Food Chem. Toxicol. 2012, 50:1600-1609.
32. Wilson B.J., Bates G.J., Nicol S.M., Gregory D.J., Perkins N.D., Fuller-Pace F.V. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol. Biol. 2004, 5:11.
33. Wu M., Xu L.G., Li X., Zhai Z., Shu H.B. AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J. Biol. Chem. 2002, 277:25617-25623.
34. Xiao J.X., Huang G.Q., Zhu C.P., Ren D.D., Zhang S.H. Morphological study on apoptosis Hela cells induced by soyasaponins. Toxicol. In Vitro 2007, 21:820-826.
35. Yang W., Fu J., Xiao X., Yan H., Bao W., Wang D., Hao L., Nussler A.K., Yao P., Liu L. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J. Sci. Food Agric. 2013, 93:1317-1325.
36. Yoshimura H., Nakamura M., Koeda T., Yoshikawa K. Mutagenicities of carbadox and olaquindox - growth promoters for pigs. Mutat. Res. 1981, 90:49-55.
37. Zhang K., Ban M., Zhao Z., Zheng H., Wang X., Wang M., Fei C., Xue F. Cytotoxicity and genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic acid (3-methylquinoxaline-2-carboxylic acid) in human hepatocytes. Res. Vet. Sci. 2012, 93:1393-1401.
38. Zhang K., Zheng W., Zheng H., Wang C., Wang M., Li T., Wang X., Zhang L., Xiao S., Fei C., Xue F. Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites. Cell Biol. Toxicol. 2014, 30(6):313-329.
39. Zhou L., Li J., Lin X., Al-Rasheid K.A. Use of RAPD to detect DNA damage induced by nitrofurazone in marine ciliate, Euplotes vannus (Protozoa Ciliophora). Aquat. Toxicol. 2011, 103:225-232.