Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways

Archives of Toxicology

Volumn 89, Issue 11, 2015, Pages 2039-2050

  Kim, Hyung Gyun ^a   Kim, Young Ran ^a   Park, Jin Hee ^a   Khanal, Tilak ^a   Choi, Jae Ho ^a   Do, Minh Truong ^a   Jin, Sun Woo ^a   Han, Eun Hee ^b   Chung, Young Ho ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

COX 2; Endosulfan; NADPH oxidase; ROS

Indexed keywords

ACETYLCYSTEINE; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; ENDOSULFAN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; PROTEIN C FOS; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; INFLAMMATION; LUCIFERASE ASSAY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM;

ACETYLCYSTEINE; ANIMALS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOSULFAN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; NADPH OXIDASE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84947572294     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1359-7     Document Type: Article

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