2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells

Archives of Toxicology

Volumn 90, Issue 9, 2016, Pages 2187-2200

  Gong, Xuezhong ^a,b   Ivanov, Vladimir N ^b   Hei, Tom K ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Columbia University ^*  (United States)

Author keywords

Arsenic response protein 2 (ARS2); Inducible heme oxygenase 1 (HO 1); Mitochondrial dysfunction; Nephrotoxicity; Nuclear factor erythroid derived 2 (Nrf2); Sodium arsenite; Tetramethylpyrazine (TMP)

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARSENIC RESPONSE PROTEIN 2; ARSENITE SODIUM; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; TETRAMETHYLPYRAZINE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; ARSENOUS ACID DERIVATIVE; ENZYME INHIBITOR; HMOX1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; NFE2L2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PYRAZINE DERIVATIVE; SODIUM DERIVATIVE; SRRT PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME HISTOCHEMISTRY; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RENAL PROTECTION; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL PROTECTION; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; TIME FACTOR;

ANTIOXIDANTS; APOPTOSIS; ARSENITES; CELL LINE; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; HEME OXYGENASE-1; HUMANS; KIDNEY TUBULES, PROXIMAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NUCLEAR PROTEINS; OXIDATIVE STRESS; PYRAZINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SODIUM COMPOUNDS; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

EID: 84944572828     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1600-z     Document Type: Article

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