TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 825-838

  Zhang, Chaoming ^a   Wang, Congcong ^a   Tang, Shusheng ^a   Sun, Yu ^a   Zhao, Dongxu ^a   Zhang, Shen ^a   Deng, Sijun ^a   Zhou, Yan ^a   Xiao, Xilong ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase; Cell cycle arrest; Mitochondria; Quinocetone; TNF

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CASPASE 3; CASPASE 8; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; QUINOCETONE; QUINOXALINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL MEMBRANE; CELL STRAIN HEPG2; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MOLECULAR MECHANICS; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALIA;

2′-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5′-BI-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE; 3-(4,5-DIMETYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; ANNEXIN V-FITC; APOPTOSIS; AV; CASPASE; CELL CYCLE ARREST; FCS; FETAL CALF SERUM; HEPG2; HOECHST 33342; HUMAN LIVER CARCINOMA CELL LINE; MAPKS; MEM; MINIMUM ESSENTIAL MEDIUM; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION; MITOGEN-ACTIVATED PROTEIN KINASES; MMP/△Ψ(M); MOMP; MTT; NC; NITROCELLULOSE; PARP; PCR; PHENYLMETHYL SULFONYLFLUORIDE; PI; PMSF; POLY(ADP-RIBOSE) POLYMERASE; POLYMERASE CHAIN REACTION; PROPIDIUM IODIDE; QDNOS; QUINOCETONE; QUINOXALINE 1,4-DIOXIDES; RH123; RHODAMINE123; SDS-PAGE; SODIUM DODECYL SULFATE POLYACRYLAMIDE GEL ELECTROPHORESIS; TBST; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE MEDIATED DUTP NICK END LABELING; TNF-Α; TRIS (HYDROXYMETHYL) AMINOMETHANE HYDROCHLORIDE; TRIS BUFFERED SALINE WITH TWEEN 20; TRIS-HCL; TUNEL;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL CYCLE; HEP G2 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; QUINOXALINES; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84887330660     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.10.022     Document Type: Article

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