Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone

Regulatory Toxicology and Pharmacology

Volumn 66, Issue 3, 2013, Pages 279-285

  Yu, Miao ^a   Xu, Mengjing ^a   Liu, Yang ^a   Yang, Wei ^a   Rong, Ying ^a   Yao, Ping ^a   Yan, Hong ^a   Wang, Di ^a   Liu, Liegang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

DNA Damage; Nephrotoxicity; Nrf2; Quinocetone; ROS

Indexed keywords

GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; QUINOCETONE; SINGLE STRANDED DNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; VETERINARY DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CELL PROTECTION; COMET ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME INHIBITION; FOOD INTAKE; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CATALASE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALE; MALONDIALDEHYDE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

ANIMALIA; RATTUS;

EID: 84878903945     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.04.005     Document Type: Article

References (33)

1. Ahamed M., Siddiqui M.K. Low level lead exposure and oxidative stress: current opinions. Clin. Chim. Acta 2007, 383(1-2):57-64.
2. Boddupalli S., et al. Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e. Front. Genet. 2012, 3:7.
3. Boettler U., et al. Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?. Mol. Biol. Rep. 2012, 39(6):7155-7162.
4. Carter W.O., Narayanan P.K., Robinson J.P. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J. Leukoc. Biol. 1994, 55(2):253-258.
5. Chen Q., et al. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem. Toxicol. 2009, 47(2):328-334.
6. Chen Y., et al. Assessment of cisplatin-induced kidney injury using an integrated rodent platform. Toxicol. Appl. Pharmacol. 2013, 268(3):352-361.
7. Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 2002, 82(1):47-95.
8. Huang X.-J., et al. ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro. Chem. Biol. Interact. 2010, 185(3):227-234.
9. Ishikado A., et al. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic. Biol. Med. 2012.
10. Jin X., et al. Investigation of quinocetone-induced genotoxicity in HepG2 cells using the comet assay, cytokinesis-block micronucleus test and RAPD analysis. Toxicol. In Vitro 2009, 23(7):1209-1214.
11. Jung K.A., Kwak M.K. The Nrf2 system as a potential target for the development of indirect antioxidants. Molecules 2010, 15(10):7266-7291.
12. Kobayashi M., Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid. Redox Signal. 2005, 7(3-4):385-394.
13. Lee P.J., Choi A.M. Pathways of cell signaling in hyperoxia. Free Radic. Biol. Med. 2003, 35(4):341-350.
14. Li W., Kong A.N. Molecular mechanisms of Nrf2-mediated antioxidant response. Mol. Carcinog. 2009, 48(2):91-104.
15. Li J.Y., et al. The effects of quinocetone on promoting broilers growth. Anim. Husbandry Vet. Med. 2007, 39(9). 0529_513.
16. Liu C.M., Ma J.Q., Sun Y.Z. Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environ. Toxicol. Pharmacol. 2010, 30(3):264-271.
17. Lowry O.H., et al. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193(1):265-275.
18. Nesslany F., et al. In vivo Comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds. Mutat. Res. 2007, 630(1-2):28-41.
19. Olive P.L., Banath J.P., Durand R.E. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. 1990. Radiat. Res. 2012, 178(2):AV3542.
20. Pedruzzi L.M., et al. Nrf2-keap1 system versus NF-kappaB: the good and the evil in chronic kidney disease?. Biochimie 2012, 94(12):2461-2466.
21. Sasaki Y.F., et al. Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutat. Res. 1997, 391(3):215-231.
22. Shah M.D., Iqbal M. Diazinon-induced oxidative stress and renal dysfunction in rats. Food Chem. Toxicol. 2010, 48(12):3345-3353.
23. Shen J., et al. Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24(3):375-383.
24. Singh N.P., et al. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175(1):184-191.
25. Sriram N., Kalayarasan S., Sudhandiran G. Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm. Pharmacol. Ther. 2009, 22(3):221-236.
26. Sun Q., et al. Ginsenoside Rb1 attenuates intestinal ischemia reperfusion induced renal injury by activating Nrf2/ARE pathway. Molecules 2012, 17(6):7195-7205.
27. Wang X., et al. Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats. Regul. Toxicol. Pharmacol. 2010, 58(3):421-427.
28. Wang X., et al. Two generation reproduction and teratogenicity studies of feeding cyadox in Wistar rats. Food Chem. Toxicol. 2011, 49(5):1068-1079.
29. Wang D., et al. Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice. Food Chem. Toxicol. 2011, 49(2):477-484.
30. Wang X., et al. Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats. Food Chem. Toxicol. 2012, 50(5):1600-1609.
31. Waring W.S., Moonie A. Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury. Clin. Toxicol. (Phila) 2011, 49(8):720-728.
32. Zhang Y., Gordon G.B. A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol. Cancer Ther. 2004, 3(7):885-893.
33. Zhou S.G. The research and application of quinocetone. Livestock Poult. Industry 2005, 7. 1008-0414.