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Volumn 9, Issue 8, 2013, Pages 1017-1027

The metabolism of carbadox, olaquindox, mequindox, quinocetone and cyadox: An overview

Author keywords

Carbadox; Cyadox; Mequindox; Metabolism; Olaquindox; Quinocetone

Indexed keywords

ANTIINFECTIVE AGENT; CARBADOX; CIADOX; MEQUINDOX; NITROGEN OXIDE; OLAQUINDOX; QUINOCETONE; UNCLASSIFIED DRUG; QUINOXALINE DERIVATIVE;

EID: 84890301350     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/1573406411309080002     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 0021234277 scopus 로고
    • Sisiter-chromatid exchange in Chinese hamster V79 cells exposed to quindoxin, carbadox and olaquindox
    • Scheutwinkel-Reich, M.; Hude, W. Sisiter-chromatid exchange in Chinese hamster V79 cells exposed to quindoxin, carbadox and olaquindox. Mut. Res., 1984, 139, 199-202.
    • (1984) Mut. Res. , vol.139 , pp. 199-202
    • Scheutwinkel-Reich, M.1    Hude, W.2
  • 2
    • 0020530983 scopus 로고
    • Cytogenetic effects of quinoxaline-1, 4-dioxide-type growth promoting agents. II. Metaphase analysis in mice
    • Cihak, R.; MVonto, R. Cytogenetic effects of quinoxaline-1, 4-dioxide-type growth promoting agents. II. Metaphase analysis in mice. Mut. Res., 1983, 117, 311-16.
    • (1983) Mut. Res. , vol.117 , pp. 311-316
    • Cihak, R.1    Mvonto, R.2
  • 3
    • 0024694305 scopus 로고
    • Comparative study of the effect of the effect of carbadox, olaquindox and cyadox on aldosterone, sodium and potassium plasma levels in weaned pigs
    • van der Molen, E.J.; Baars, A.J.; de Graaf, G.J.; Jager, L.P. Comparative study of the effect of the effect of carbadox, olaquindox and cyadox on aldosterone, sodium and potassium plasma levels in weaned pigs. Res. Vet. Sci., 1989, 47, 11-6.
    • (1989) Res. Vet. Sci. , vol.47 , pp. 11-16
    • Van Der Molen, E.J.1    Baars, A.J.2    De Graaf, G.J.3    Jager, L.P.4
  • 4
    • 0037165491 scopus 로고    scopus 로고
    • Teratogenic assessment of carbadox in rats
    • Yoshimura, H. Teratogenic assessment of carbadox in rats. Toxicol. Lett., 2002, 129, 115-8.
    • (2002) Toxicol. Lett. , vol.129 , pp. 115-118
    • Yoshimura, H.1
  • 5
    • 84890259394 scopus 로고
    • Commission Regulation No 2788/ 98
    • Commission Regulation No. 2788/98, Official J. Eur. Commun. 1988; L347: 31-32.
    • (1988) Official J. Eur. Commun. , vol.L347 , pp. 31-32
  • 11
    • 0019847072 scopus 로고
    • Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides
    • Beutin, L.; Preller, E.; Kowalski, B. Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides. Antimicrob. Agents Chemother., 1981, 20, 336-43.
    • (1981) Antimicrob. Agents Chemother. , vol.20 , pp. 336-343
    • Beutin, L.1    Preller, E.2    Kowalski, B.3
  • 14
    • 58149483488 scopus 로고    scopus 로고
    • Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells
    • Chen, Q.; Tang, S.; Jin, X.; Zou, J.; Chen, K.; Zhang, T.; Xiao, X. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem. Toxicol., 2009, 47, 328-34.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 328-334
    • Chen, Q.1    Tang, S.2    Jin, X.3    Zou, J.4    Chen, K.5    Zhang, T.6    Xiao, X.7
  • 15
    • 61849174648 scopus 로고    scopus 로고
    • A determinative and confirmatory method for residues of the metabolites of carbadox and olaquindox in porcine tissues
    • Boison, J. O.; Lee, S.C.; Gedir R.G. A determinative and confirmatory method for residues of the metabolites of carbadox and olaquindox in porcine tissues. Anal. Chim. Acta. 2009, 637, 128-34.
    • (2009) Anal. Chim. Acta. , vol.637 , pp. 128-134
    • Boison, J.O.1    Lee, S.C.2    Gedir, R.G.3
  • 16
    • 78650758574 scopus 로고    scopus 로고
    • Identification of carbadox metabolites formed by liver microsomes from rats, pigs and chickens using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry
    • Liu, Z.Y.; Tao, Y.F.; Chen, D.M.; Wang, X.; Yuan, Z.H. Identification of carbadox metabolites formed by liver microsomes from rats, pigs and chickens using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. Rapid. Commun. Mass Spectrom., 2011, 25, 341-48.
    • (2011) Rapid. Commun. Mass Spectrom. , vol.25 , pp. 341-348
    • Liu, Z.Y.1    Tao, Y.F.2    Chen, D.M.3    Wang, X.4    Yuan, Z.H.5
  • 18
    • 0024119914 scopus 로고
    • Liquid chromatographic determination of olaquindox in medicated feeds and in contents of porcine gastrointestinal tract
    • Spierenburg, T.; Van Lenthe, H.; De Graaf, G.; Jager, L.P. Liquid chromatographic determination of olaquindox in medicated feeds and in contents of porcine gastrointestinal tract. J. AOAC. Int., 1988, 71, 1106-9.
    • (1988) J. AOAC. Int. , vol.71 , pp. 1106-1109
    • Spierenburg, T.1    Van Lenthe, H.2    De Graaf, G.3    Jager, L.P.4
  • 19
    • 41549117154 scopus 로고    scopus 로고
    • Metabolism of olaquindox in rat liver microsomes: Structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry
    • Liu, Z.; Huang, L.; Dai, M.; Chen, D.; Wang, Y.; Tao, Y.; Yuan, Z. Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrum., 2008, 22, 1009-16.
    • (2008) Rapid Commun. Mass Spectrum. , vol.22 , pp. 1009-1016
    • Liu, Z.1    Huang, L.2    Dai, M.3    Chen, D.4    Wang, Y.5    Tao, Y.6    Yuan, Z.7
  • 20
    • 77951891943 scopus 로고    scopus 로고
    • The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, pigs and chicken
    • Liu, Z.Y.; Huang, L.L.; Chen, D.M.; Dai, M.H.; Tao, Y.F.; Yuan, Z.H. The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, pigs and chicken. Toxicol. Lett., 2010, 195, 51-9.
    • (2010) Toxicol. Lett. , vol.195 , pp. 51-59
    • Liu, Z.Y.1    Huang, L.L.2    Chen, D.M.3    Dai, M.H.4    Tao, Y.F.5    Yuan, Z.H.6
  • 22
    • 79952805966 scopus 로고    scopus 로고
    • Metabolism of olaquindox in rat and identification of metabolites in urine and feces using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Bi, Y.; Wang, X.; Xu, S.; Sun, L.; Zhang, L.; Zhong, F.; Wang, S.; Ding, S.; Xiao, X. Metabolism of olaquindox in rat and identification of metabolites in urine and feces using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid Commun. Mass Spectrum., 2011, 25, 889-98.
    • (2011) Rapid Commun. Mass Spectrum , vol.25 , pp. 889-898
    • Bi, Y.1    Wang, X.2    Xu, S.3    Sun, L.4    Zhang, L.5    Zhong, F.6    Wang, S.7    Ding, S.8    Xiao, X.9
  • 23
    • 0030772328 scopus 로고    scopus 로고
    • The role of non-p450 enzymes in drug oxidation
    • Beedham, C. The role of non-p450 enzymes in drug oxidation. Pharm. World Sci., 1997, 19, 255-63.
    • (1997) Pharm. World Sci. , vol.19 , pp. 255-263
    • Beedham, C.1
  • 24
    • 0034534311 scopus 로고    scopus 로고
    • Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism
    • Vasiliou, V.; Pappa, A.; Petersen, D.R. Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism. Chem. Biol. Interact., 2000, 129, 1-19.
    • (2000) Chem. Biol. Interact. , vol.129 , pp. 1-19
    • Vasiliou, V.1    Pappa, A.2    Petersen, D.R.3
  • 25
    • 78650020625 scopus 로고    scopus 로고
    • In vitro biotranformation and investigaton of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken and pigs
    • Liu, Z.Y.; Chen, D.M.; Huang, L.L.; Tao, Y.F.; Yao, M.; Yuan, Z.H. In vitro biotranformation and investigaton of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken and pigs. Toxicol., 2011, 279, 155-66.
    • (2011) Toxicol. , vol.279 , pp. 155-166
    • Liu, Z.Y.1    Chen, D.M.2    Huang, L.L.3    Tao, Y.F.4    Yao, M.5    Yuan, Z.H.6
  • 26
    • 84861483058 scopus 로고    scopus 로고
    • Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration
    • Ding, H.; Liu, Y.; Zeng, Z.; Si, H.; Liu, K.; Liu, Y.; Yang, F.; Li, Y.; Zeng, D. Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration. Res. Vet. Sci., 2012, 93, 1380-6.
    • (2012) Res. Vet. Sci. , vol.93 , pp. 1380-1386
    • Ding, H.1    Liu, Y.2    Zeng, Z.3    Si, H.4    Liu, K.5    Liu, Y.6    Yang, F.7    Li, Y.8    Zeng, D.9
  • 28
    • 84866870685 scopus 로고    scopus 로고
    • Pharmacokinetics of mequindox in rabbits with experimental hepatic injury. J. Northwest A&F Univ
    • Lu, C.W.; Li, Y.Q.; Guan, Y.J.; Zhang, Y.B.; Bai, D.Y.; Miao, X.L.; Xiong, Y.J. Pharmacokinetics of mequindox in rabbits with experimental hepatic injury. J. Northwest A&F Univ. Nat. Sci. Ed., 2008, 36, 29-34
    • (2008) Nat. Sci. Ed. , vol.36 , pp. 29-34
    • Lu, C.W.1    Li, Y.Q.2    Guan, Y.J.3    Zhang, Y.B.4    Bai, D.Y.5    Miao, X.L.6    Xiong, Y.J.7
  • 30
    • 77949602182 scopus 로고    scopus 로고
    • Metabolism of mequindox in liver microsomes of rats, chicken and pigs
    • Liu, Z.; Huang, L.; Chen, D.; Yuan, Z. Metabolism of mequindox in liver microsomes of rats, chicken and pigs. Rapid Commun. Mass Spectrum., 2010, 24, 909-18.
    • (2010) Rapid Commun. Mass Spectrum. , vol.24 , pp. 909-918
    • Liu, Z.1    Huang, L.2    Chen, D.3    Yuan, Z.4
  • 31
    • 84855899288 scopus 로고    scopus 로고
    • Identification mequindox and its metabolites by high performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry
    • Liu, Y.C.; Si, H.B.; He, L.M.; Ding, H.Z.; Huang, X.H.; Chen, J.X.; Chen, Z.L.; Zeng, Z.L. Identification mequindox and its metabolites by high performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Chin. J. Anal. Chem., 2010, 38, 82-6.
    • (2010) Chin. J. Anal. Chem. , vol.38 , pp. 82-86
    • Liu, Y.C.1    Si, H.B.2    He, L.M.3    Ding, H.Z.4    Huang, X.H.5    Chen, J.X.6    Chen, Z.L.7    Zeng, Z.L.8
  • 33
    • 84863352299 scopus 로고    scopus 로고
    • Carbonyl reduction of mequindox by chicken and porcine cytosol and cloned CBR1
    • Tang, X.; Mu, P.; Wu, J.; Jiang, J.; Zhang, C.; Zheng, M.; Deng, Y. Carbonyl reduction of mequindox by chicken and porcine cytosol and cloned CBR1. Drug Metab. Dispos., 2012, 40, 788-95.
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 788-795
    • Tang, X.1    Mu, P.2    Wu, J.3    Jiang, J.4    Zhang, C.5    Zheng, M.6    Deng, Y.7
  • 36
    • 84890308715 scopus 로고    scopus 로고
    • Study on the pharmacokinetics in pigs and chickens of quinocetone in PO
    • Li, J.; Zhao, R.; Li, J.; Xu, Z.; Liu, J.; Xue, F. Study on the pharmacokinetics in pigs and chickens of quinocetone in PO. Chinese J. Vet. Sci., 2000, 35, 15-7.
    • (2000) Chinese J. Vet. Sci. , vol.35 , pp. 15-17
    • Li, J.1    Zhao, R.2    Li, J.3    Xu, Z.4    Liu, J.5    Xue, F.6
  • 37
    • 16644403496 scopus 로고    scopus 로고
    • Development of liquid chromatographic methods for determination of quinocetone and its main metabolites in edible tissues of swine and chicken
    • Huang, L.; Xiao, A.; Fan, S.; Yin, J.; Chen, P.; Liu, D.; Qiu, Y.; Wang, Y.; Yuan, Z. Development of liquid chromatographic methods for determination of quinocetone and its main metabolites in edible tissues of swine and chicken. J. AOAC Int., 2005, 88, 472-8.
    • (2005) J. AOAC Int. , vol.88 , pp. 472-478
    • Huang, L.1    Xiao, A.2    Fan, S.3    Yin, J.4    Chen, P.5    Liu, D.6    Qiu, Y.7    Wang, Y.8    Yuan, Z.9
  • 38
    • 76749155438 scopus 로고    scopus 로고
    • Application of electrospray ionization hybrid ion trap/ time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro
    • Liu, Z.Y.; Huang, L.L.; Chen, D.M.; Dai, M.H.; Tao, Y.F.; Wang, Y.L.; Yuan, Z.H. Application of electrospray ionization hybrid ion trap/ time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro. Anal. Bioanal. Chem., 2010, 396, 1259-71.
    • (2010) Anal. Bioanal. Chem. , vol.396 , pp. 1259-1271
    • Liu, Z.Y.1    Huang, L.L.2    Chen, D.M.3    Dai, M.H.4    Tao, Y.F.5    Wang, Y.L.6    Yuan, Z.H.7
  • 39
    • 74249122086 scopus 로고    scopus 로고
    • Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatograph electrospray ionization quadrupole time-of-flight tandem spectrometry
    • Shen, J.; Yang, C.; Wu, C.; Feng, P.; Wang, Z.; Li, Y.; Li, Y.; Zhang, S. Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatograph electrospray ionization quadrupole time-of-flight tandem spectrometry. Rapid Commun. Mass Spectrom., 2010, 24, 375-83.
    • (2010) Rapid Commun. Mass Spectrom. , vol.24 , pp. 375-383
    • Shen, J.1    Yang, C.2    Wu, C.3    Feng, P.4    Wang, Z.5    Li, Y.6    Li, Y.7    Zhang, S.8
  • 40
    • 84863698547 scopus 로고    scopus 로고
    • Metabolism profile of quinocetone in swine by ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry
    • Wu, H.; Yang, C.; Wang, Z.; Shen, J.; Zhang, S.; Feng, P.; Li, L.; Cheng, L. Metabolism profile of quinocetone in swine by ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry. Eur. J. Drug Metab. Pharmacokinet., 2012, 37, 141-54.
    • (2012) Eur. J. Drug Metab. Pharmacokinet. , vol.37 , pp. 141-154
    • Wu, H.1    Yang, C.2    Wang, Z.3    Shen, J.4    Zhang, S.5    Feng, P.6    Li, L.7    Cheng, L.8
  • 41
    • 85044710378 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue depletion of cyadox and its two metabolites in pigs and broilers
    • Huang, L.; Qiu, Y.; Wang, Y.; Wang, X.; Fang, K.; Chen, D.; Tao, Y.; Liu, Z.; Yuan, Z. Pharmacokinetics and tissue depletion of cyadox and its two metabolites in pigs and broilers. J. Agric. Food Chem., 2012, 60, 3329-35.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 3329-3335
    • Huang, L.1    Qiu, Y.2    Wang, Y.3    Wang, X.4    Fang, K.5    Chen, D.6    Tao, Y.7    Liu, Z.8    Yuan, Z.9
  • 43
    • 2042535787 scopus 로고
    • Determination of cyadox and its metabolites in plasma by adsorptive voltammetry
    • Sestakova, I.; Kopanica, M. Determination of cyadox and its metabolites in plasma by adsorptive voltammetry. Tanlanta, 1988, 35, 816-8.
    • (1988) Tanlanta , vol.35 , pp. 816-818
    • Sestakova, I.1    Kopanica, M.2
  • 44
    • 67650360063 scopus 로고    scopus 로고
    • Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry
    • Liu, Z.; Huang, L.; Dai, M.; Chen, D.; Tao, Y.; Wang, Y.; Yuan, Z. Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrum., 2009, 23, 2026-34.
    • (2009) Rapid Commun. Mass Spectrum. , vol.23 , pp. 2026-2034
    • Liu, Z.1    Huang, L.2    Dai, M.3    Chen, D.4    Tao, Y.5    Wang, Y.6    Yuan, Z.7
  • 45
    • 80053296914 scopus 로고    scopus 로고
    • Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry
    • Xu. N.; Huang, L.; Liu, Z.; Pan, Y.; Wang, X.; Tao, Y.; Chen, D.; Wang, Y.; Peng, D.; Yuan, Z. Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrum., 2011, 25, 2333-44.
    • (2011) Rapid Commun. Mass Spectrum. , vol.25 , pp. 2333-2344
    • Xu., N.1    Huang, L.2    Liu, Z.3    Pan, Y.4    Wang, X.5    Tao, Y.6    Chen, D.7    Wang, Y.8    Peng, D.9    Yuan, Z.10
  • 46
    • 80053947167 scopus 로고    scopus 로고
    • The mechanism of enzymatic and non-enzymatic N-oxide reductive metabolism of cyadox in pig liver
    • Zheng, M.; Jiang, J.; Wang, J.; Tang, X.; Ouyang, M.; Deng, Y. The mechanism of enzymatic and non-enzymatic N-oxide reductive metabolism of cyadox in pig liver. Xenobiotica. 2011, 41, 964-71.
    • (2011) Xenobiotica , vol.41 , pp. 964-971
    • Zheng, M.1    Jiang, J.2    Wang, J.3    Tang, X.4    Ouyang, M.5    Deng, Y.6
  • 50
    • 78951491598 scopus 로고    scopus 로고
    • Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice
    • Wang, D.; Zhong, Y.; Luo, X.; Wu, S.; Xiao, R.; Bao, W.; Yang, W.; Yan, H.; Yao, P.; Liu, L. Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice. Food Chem. Toxicol., 2011, 49, 477-84.
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 477-484
    • Wang, D.1    Zhong, Y.2    Luo, X.3    Wu, S.4    Xiao, R.5    Bao, W.6    Yang, W.7    Yan, H.8    Yao, P.9    Liu, L.10


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