Enzyme-activated, hypoxia-selective DNA damage by 3-amino-2- quinoxalinecarbonitrile 1,4-di-N-oxide

Chemical Research in Toxicology

Volumn 17, Issue 11, 2004, Pages 1399-1405

  Chowdhury, Goutam ^a   Kotandeniya, Delshanee ^a   Daniels, J Scott ^a   Barnes, Charles L ^a,b   Gates, Kent S ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 QUINOXALINECARBONITRILE 1,4 DIOXIDE; DEOXYRIBOSE; DNA; DOUBLE STRANDED DNA; OXIDE; OXYGEN; RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; TIRAPAZAMINE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

AGAR GEL ELECTROPHORESIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ANOXIA; ANTINEOPLASTIC AGENTS; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; NADPH-FERRIHEMOPROTEIN REDUCTASE; NITRILES; OXIDES; QUINOXALINES;

GOES;

EID: 8844256506     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049836w     Document Type: Article

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