Modeling ALS with motor neurons derived from human induced pluripotent stem cells

Nature Neuroscience

Volumn 19, Issue 4, 2016, Pages 542-553

  Sances, Samuel ^a   Bruijn, Lucie I ^b   Chandran, Siddharthan ^c   Eggan, Kevin ^d   Ho, Ritchie ^a   Klim, Joseph R ^e   Livesey, Matt R ^c,f   Lowry, Emily ^g   Macklis, Jeffrey D ^d,e,h   Rushton, David ^a   Sadegh, Cameron ^d,e,h   Sareen, Dhruv ^a   Wichterle, Hynek ^g   Zhang, Su Chun ⁱ   Svendsen, Clive N ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b ALS Association   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e Harvard University   (United States)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g NewYork Presbyterian Hospital   (United States)

^h HARVARD UNIVERSITY   (United States)

ⁱ UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 8; GROWTH DIFFERENTIATION FACTOR; GROWTH DIFFERENTIATION FACTOR 11; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN ELECTROPHYSIOLOGY; BRAIN MATURATION; CELL INTERACTION; CELL MATURATION; COCULTURE; DISEASE MODEL; GENE EXPRESSION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; MOTONEURON; NEOCORTEX; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE PROJECTION; NEUROMUSCULAR FUNCTION; NEUROPATHOLOGY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SODIUM CURRENT; TELENCEPHALON; TRANSCRIPTION REGULATION; WNT SIGNALING; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; PATHOLOGY; PHYSIOLOGY; PROCEDURES;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MOTOR NEURONS;

EID: 85010870303     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.4273     Document Type: Review

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