A quantitative framework to evaluate modeling of cortical development by neural stem cells

Neuron

Volumn 83, Issue 1, 2014, Pages 69-86

  Stein, Jason L ^a   de la Torre Ubieta, Luis ^a   Tian, Yuan ^a   Parikshak, Neelroop N ^a   Hernández, Israel A ^b   Marchetto, Maria C ^c   Baker, Dylan K ^a   Lu, Daning ^a   Hinman, Cassidy R ^b   Lowe, Jennifer K ^a   Wexler, Eric M ^a   Muotri, Alysson R ^d   Gage, Fred H ^c   Kosik, Kenneth S ^b   Geschwind, Daniel H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME;

ARTICLE; AUTISM; BIOLOGICAL MODEL; BRAIN DEVELOPMENT; BRAIN REGION; COMPARATIVE STUDY; FEMALE; FETUS; GENE EXPRESSION; GENE EXPRESSION NETWORK ARCHITECTURE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MACHINE LEARNING; MALE; MARKER GENE; MATURITY; MORPHOGENESIS; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROPSYCHIATRY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; QUANTITATIVE STUDY; REGIONAL IDENTITY; SYSTEM BIOLOGY FRAMEWORK; TRANSCRIPTOMICS;

ARTIFICIAL INTELLIGENCE; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYONIC STEM CELLS; FEMALE; GENE REGULATORY NETWORKS; HUMANS; MALE; MODELS, NEUROLOGICAL; NEURAL STEM CELLS;

EID: 84903574160     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.05.035     Document Type: Article

References (95)

1. Akbarian S., Kim J.J., Potkin S.G., Hetrick W.P., Bunney W.E., Jones E.G. Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Arch. Gen. Psychiatry 1996, 53:425-436.
2. An M.C., Zhang N., Scott G., Montoro D., Wittkop T., Mooney S., Melov S., Ellerby L.M. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell 2012, 11:253-263.
3. Andersen S.L. Trajectories of brain development: point of vulnerability or window of opportunity?. Neurosci. Biobehav. Rev. 2003, 27:3-18.
4. Anderson S.A., Volk D.W., Lewis D.A. Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects. Schizophr. Res. 1996, 19:111-119.
5. Andrews P.W., Benvenisty N., McKay R., Pera M.F., Rossant J., Semb H., Stacey G.N. The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research. Nat. Biotechnol. 2005, 23:795-797. Steering Committee of the International Stem Cell Initiative.
6. Arlotta P., Molyneaux B.J., Chen J., Inoue J., Kominami R., Macklis J.D. Neuronal subtype-specific genes that control corticospinal motor neuron development invivo. Neuron 2005, 45:207-221.
7. Banerjee-Basu S., Packer A. SFARI Gene: an evolving database for the autism research community. Dis. Model. Mech. 2010, 3:133-135.
8. Bayés A., van de Lagemaat L.N., Collins M.O., Croning M.D., Whittle I.R., Choudhary J.S., Grant S.G. Characterization of the proteome, diseases and evolution of the human postsynaptic density. Nat. Neurosci. 2011, 14:19-21.
9. Benjamini Y., Hochberg Y. Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing. J.Roy. Sta.t Soc. B. Met. 1995, 57:289-300.
10. Betizeau M., Cortay V., Patti D., Pfister S., Gautier E., Bellemin-Ménard A., Afanassieff M., Huissoud C., Douglas R.J., Kennedy H., Dehay C. Precursor diversity and complexity of lineage relationships in the outer subventricular zone of the primate. Neuron 2013, 80:442-457.
11. Brennand K.J., Simone A., Jou J., Gelboin-Burkhart C., Tran N., Sangar S., Li Y., Mu Y., Chen G., Yu D., et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011, 473:221-225.
12. Brennand K., Savas J.N., Kim Y., Tran N., Simone A., Hashimoto-Torii K., Beaumont K.G., Kim H.J., Topol A., Ladran I., et al. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Mol. Psychiatry 2014, 10.1038/mp.2014.22.
13. Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M., Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat. Neurosci. 2006, 9:917-924.
14. Colantuoni C., Lipska B.K., Ye T., Hyde T.M., Tao R., Leek J.T., Colantuoni E.A., Elkahloun A.G., Herman M.M., Weinberger D.R., Kleinman J.E. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 2011, 478:519-523.
15. Dolmetsch R., Geschwind D.H. The human brain in a dish: the promise of iPSC-derived neurons. Cell 2011, 145:831-834.
16. Ebert D.H., Greenberg M.E. Activity-dependent neuronal signalling and autism spectrum disorder. Nature 2013, 493:327-337.
17. Englund C., Fink A., Lau C., Pham D., Daza R.A., Bulfone A., Kowalczyk T., Hevner R.F. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J.Neurosci. 2005, 25:247-251.
18. Espuny-Camacho I., Michelsen K.A., Gall D., Linaro D., Hasche A., Bonnefont J., Bali C., Orduz D., Bilheu A., Herpoel A., et al. Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits invivo. Neuron 2013, 77:440-456.
19. Falk A., Koch P., Kesavan J., Takashima Y., Ladewig J., Alexander M., Wiskow O., Tailor J., Trotter M., Pollard S., et al. Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for invitro production of human neurons. PLoS ONE 2012, 7:e29597.
20. Fathi A., Hatami M., Hajihosseini V., Fattahi F., Kiani S., Baharvand H., Salekdeh G.H. Comprehensive gene expression analysis of human embryonic stem cells during differentiation into neural cells. PLoS ONE 2011, 6:e22856.
21. Fietz S.A., Kelava I., Vogt J., Wilsch-Brauninger M., Stenzel D., Fish J.L., Corbeil D., Riehn A., Distler W., Nitsch R., et al. OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nat. Neurosci. 2010, 13:690-699.
22. Fuhrmann M., Bittner T., Jung C.K., Burgold S., Page R.M., Mitteregger G., Haass C., LaFerla F.M., Kretzschmar H., Herms J. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat. Neurosci. 2010, 13:411-413.
23. Gleeson J.G., Lin P.T., Flanagan L.A., Walsh C.A. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 1999, 23:257-271.
24. Goshima Y., Nakamura F., Strittmatter P., Strittmatter S.M. Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature 1995, 376:509-514.
25. Gulsuner S., Walsh T., Watts A.C., Lee M.K., Thornton A.M., Casadei S., Rippey C., Shahin H., Nimgaonkar V.L., Go R.C., et al. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell 2013, 154:518-529. Consortium on the Genetics of Schizophrenia (COGS), PAARTNERS Study GroupPAARTNERS Study Group.
26. Haase A., Olmer R., Schwanke K., Wunderlich S., Merkert S., Hess C., Zweigerdt R., Gruh I., Meyer J., Wagner S., et al. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 2009, 5:434-441.
27. Hansen D.V., Lui J.H., Parker P.R., Kriegstein A.R. Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 2010, 464:554-561.
28. Hansen D.V., Rubenstein J.L., Kriegstein A.R. Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron 2011, 70:645-660.
29. Hawrylycz M.J., Lein E.S., Guillozet-Bongaarts A.L., Shen E.H., Ng L., Miller J.A., van de Lagemaat L.N., Smith K.A., Ebbert A., Riley Z.L., et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 2012, 489:391-399.
30. Hernandez D.G., Nalls M.A., Moore M., Chong S., Dillman A., Trabzuni D., Gibbs J.R., Ryten M., Arepalli S., Weale M.E., et al. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiol. Dis. 2012, 47:20-28.
31. Hutsler J.J., Zhang H. Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. Brain Res. 2010, 1309:83-94.
32. Inlow J.K., Restifo L.L. Molecular and comparative genetics of mental retardation. Genetics 2004, 166:835-881.
33. Iossifov I., Ronemus M., Levy D., Wang Z., Hakker I., Rosenbaum J., Yamrom B., Lee Y.H., Narzisi G., Leotta A., et al. De novo gene disruptions in children on the autistic spectrum. Neuron 2012, 74:285-299.
34. Israel M.A., Yuan S.H., Bardy C., Reyna S.M., Mu Y., Herrera C., Hefferan M.P., Van Gorp S., Nazor K.L., Boscolo F.S., et al. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 2012, 482:216-220.
35. Johnson M.B., Kawasawa Y.I., Mason C.E., Krsnik Z., Coppola G., Bogdanović D., Geschwind D.H., Mane S.M., State M.W., Sestan N. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 2009, 62:494-509.
36. Kadoshima T., Sakaguchi H., Nakano T., Soen M., Ando S., Eiraku M., Sasai Y. Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc. Natl. Acad. Sci. USA 2013, 110:20284-20289.
37. Kageyama R., Ohtsuka T., Shimojo H., Imayoshi I. Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nat. Neurosci. 2008, 11:1247-1251.
38. Kang H.J., Kawasawa Y.I., Cheng F., Zhu Y., Xu X., Li M., Sousa A.M., Pletikos M., Meyer K.A., Sedmak G., et al. Spatio-temporal transcriptome of the human brain. Nature 2011, 478:483-489.
39. Kang P., Lee H.K., Glasgow S.M., Finley M., Donti T., Gaber Z.B., Graham B.H., Foster A.E., Novitch B.G., Gronostajski R.M., Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron 2012, 74:79-94.
40. Kim J.H., Auerbach J.M., Rodríguez-Gómez J.A., Velasco I., Gavin D., Lumelsky N., Lee S.H., Nguyen J., Sánchez-Pernaute R., Bankiewicz K., McKay R. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002, 418:50-56.
41. Konopka G., Wexler E., Rosen E., Mukamel Z., Osborn G.E., Chen L., Lu D., Gao F., Gao K., Lowe J.K., Geschwind D.H. Modeling the functional genomics of autism using human neurons. Mol. Psychiatry 2012, 17:202-214.
42. Kriegstein A., Alvarez-Buylla A. The glial nature of embryonic and adult neural stem cells. Annu. Rev. Neurosci. 2009, 32:149-184.
43. Lancaster M.A., Renner M., Martin C.A., Wenzel D., Bicknell L.S., Hurles M.E., Homfray T., Penninger J.M., Jackson A.P., Knoblich J.A. Cerebral organoids model human brain development and microcephaly. Nature 2013, 501:373-379.
44. Langfelder P., Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 2008, 9:559.
45. Langfelder P., Luo R., Oldham M.C., Horvath S. Is my network module preserved and reproducible?. PLoS Comput. Biol. 2011, 7:e1001057.
46. Levinson D.F., Duan J., Oh S., Wang K., Sanders A.R., Shi J., Zhang N., Mowry B.J., Olincy A., Amin F., et al. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am. J. Psychiatry 2011, 168:302-316.
47. Liu X., Somel M., Tang L., Yan Z., Jiang X., Guo S., Yuan Y., He L., Oleksiak A., Zhang Y., et al. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 2012, 22:611-622.
48. Lubs H.A., Stevenson R.E., Schwartz C.E. Fragile X and X-linked intellectual disability: four decades of discovery. Am. J. Hum. Genet. 2012, 90:579-590.
49. Manuel M., Price D.J. Role of Pax6 in forebrain regionalization. Brain Res. Bull. 2005, 66:387-393.
50. Marchetto M.C., Carromeu C., Acab A., Yu D., Yeo G.W., Mu Y., Chen G., Gage F.H., Muotri A.R. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010, 143:527-539.
51. Mariani J., Simonini M.V., Palejev D., Tomasini L., Coppola G., Szekely A.M., Horvath T.L., Vaccarino F.M. Modeling human cortical development invitro using induced pluripotent stem cells. Proc. Natl. Acad. Sci. USA 2012, 109:12770-12775.
52. McEvilly R.J., de Diaz M.O., Schonemann M.D., Hooshmand F., Rosenfeld M.G. Transcriptional regulation of cortical neuron migration by POU domain factors. Science 2002, 295:1528-1532.
53. Merkle F.T., Eggan K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell 2013, 12:656-668.
54. Millar J.K., Pickard B.S., Mackie S., James R., Christie S., Buchanan S.R., Malloy M.P., Chubb J.E., Huston E., Baillie G.S., et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 2005, 310:1187-1191.
55. Miller J.A., Ding S.-L., Sunkin S.M., Smith K.A., Ng L., Szafer A., Ebbert A., Riley Z.L., Royall J.J., Aiona K., et al. Transcriptional landscape of the prenatal human brain. Nature 2014, 508:199-206.
56. Molyneaux B.J., Arlotta P., Menezes J.R., Macklis J.D. Neuronal subtype specification in the cerebral cortex. Nat. Rev. Neurosci. 2007, 8:427-437.
57. Naj A.C., Jun G., Beecham G.W., Wang L.S., Vardarajan B.N., Buros J., Gallins P.J., Buxbaum J.D., Jarvik G.P., Crane P.K., et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat. Genet. 2011, 43:436-441.
58. Neale B.M., Kou Y., Liu L., Ma'ayan A., Samocha K.E., Sabo A., Lin C.F., Stevens C., Wang L.S., Makarov V., et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 2012, 485:242-245.
59. Nicholas C.R., Chen J., Tang Y., Southwell D.G., Chalmers N., Vogt D., Arnold C.M., Chen Y.J., Stanley E.G., Elefanty A.G., et al. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell 2013, 12:573-586.
60. Nishida Y., Adati N., Ozawa R., Maeda A., Sakaki Y., Takeda T. Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y. BMC Res. Notes 2008, 1:95.
61. O'Roak B.J., Vives L., Girirajan S., Karakoc E., Krumm N., Coe B.P., Levy R., Ko A., Lee C., Smith J.D., et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 2012, 485:246-250.
62. Obokata H., Wakayama T., Sasai Y., Kojima K., Vacanti M.P., Niwa H., Yamato M., Vacanti C.A. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature 2014, 505:641-647.
63. Oldham M.C., Konopka G., Iwamoto K., Langfelder P., Kato T., Horvath S., Geschwind D.H. Functional organization of the transcriptome in human brain. Nat. Neurosci. 2008, 11:1271-1282.
64. Palmer T.D., Schwartz P.H., Taupin P., Kaspar B., Stein S.A., Gage F.H. Cell culture. Progenitor cells from human brain after death. Nature 2001, 411:42-43.
65. Paolicelli R.C., Bolasco G., Pagani F., Maggi L., Scianni M., Panzanelli P., Giustetto M., Ferreira T.A., Guiducci E., Dumas L., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 333:1456-1458.
66. Parikshak N.N., Luo R., Zhang A., Won H., Lowe J.K., Chandran V., Horvath S., Geschwind D.H. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell 2013, 155:1008-1021.
67. Paşca S.P., Portmann T., Voineagu I., Yazawa M., Shcheglovitov A., Paşca A.M., Cord B., Palmer T.D., Chikahisa S., Nishino S., et al. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat. Med. 2011, 17:1657-1662.
68. Penzes P., Cahill M.E., Jones K.A., VanLeeuwen J.E., Woolfrey K.M. Dendritic spine pathology in neuropsychiatric disorders. Nat. Neurosci. 2011, 14:285-293.
69. Pinheiro J., Bates D. Mixed-Effects Models in S and S-PLUS 2009, Springer, New York. Second Edition.
70. Plaisier S.B., Taschereau R., Wong J.A., Graeber T.G. Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures. Nucleic Acids Res. 2010, 38:e169.
71. Rakic P. Developmental and evolutionary adaptations of cortical radial glia. Cereb. Cortex 2003, 13:541-549.
72. Read J. Scalable Multi-label Classification 2010, University of Waikato, Hamilton, New Zealand.
73. Ripke S., O'Dushlaine C., Chambert K., Moran J.L., Kähler A.K., Akterin S., Bergen S.E., Collins A.L., Crowley J.J., Fromer M., et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat. Genet. 2013, 45:1150-1159. Multicenter Genetic Studies of Schizophrenia Consortium, Psychosis Endophenotypes International ConsortiumPsychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2Wellcome Trust Case Control Consortium 2.
74. Ropers H.H. Genetics of intellectual disability. Curr. Opin. Genet. Dev. 2008, 18:241-250.
75. Rosen E.Y., Wexler E.M., Versano R., Coppola G., Gao F., Winden K.D., Oldham M.C., Martens L.H., Zhou P., Farese R.V., Geschwind D.H. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron 2011, 71:1030-1042.
76. Ryan S.D., Dolatabadi N., Chan S.F., Zhang X., Akhtar M.W., Parker J., Soldner F., Sunico C.R., Nagar S., Talantova M., et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell 2013, 155:1351-1364.
77. Sanders S.J., Ercan-Sencicek A.G., Hus V., Luo R., Murtha M.T., Moreno-De-Luca D., Chu S.H., Moreau M.P., Gupta A.R., Thomson S.A., et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011, 70:863-885.
78. Sanders S.J., Murtha M.T., Gupta A.R., Murdoch J.D., Raubeson M.J., Willsey A.J., Ercan-Sencicek A.G., DiLullo N.M., Parikshak N.N., Stein J.L., et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 2012, 485:237-241.
79. Sandoe J., Eggan K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat. Neurosci. 2013, 16:780-789.
80. Soldner F., Laganière J., Cheng A.W., Hockemeyer D., Gao Q., Alagappan R., Khurana V., Golbe L.I., Myers R.H., Lindquist S., et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 2011, 146:318-331.
81. Sousa V.H., Fishell G. Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. Curr. Opin. Genet. Dev. 2010, 20:391-399.
82. Stolt C.C., Lommes P., Sock E., Chaboissier M.C., Schedl A., Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003, 17:1677-1689.
83. Strauss K.A., Puffenberger E.G., Huentelman M.J., Gottlieb S., Dobrin S.E., Parod J.M., Stephan D.A., Morton D.H. Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N.Engl. J. Med. 2006, 354:1370-1377.
84. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
85. Taylor S.S., McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 1997, 89:727-735.
86. Tsoumakas G., Katakis I. Multi-Label Classification: An Overview. Int. J. Data Warehous. Min. 2007, 3:1-13.
87. Tuoc T.C., Boretius S., Sansom S.N., Pitulescu M.E., Frahm J., Livesey F.J., Stoykova A. Chromatin regulation by BAF170 controls cerebral cortical size and thickness. Dev. Cell 2013, 25:256-269.
88. van Bokhoven H. Genetic and epigenetic networks in intellectual disabilities. Annu. Rev. Genet. 2011, 45:81-104.
89. Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 2005, 57:67-81.
90. Voineagu I., Wang X., Johnston P., Lowe J.K., Tian Y., Horvath S., Mill J., Cantor R.M., Blencowe B.J., Geschwind D.H. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 2011, 474:380-384.
91. Wegiel J., Schanen N.C., Cook E.H., Sigman M., Brown W.T., Kuchna I., Nowicki K., Wegiel J., Imaki H., Ma S.Y., et al. Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism. J.Neuropathol. Exp. Neurol. 2012, 71:382-397.
92. Wexler E.M., Rosen E., Lu D., Osborn G.E., Martin E., Raybould H., Geschwind D.H. Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways. Sci. Signal. 2011, 4:ra65.
93. Wilkinson M., Hume R., Strange R., Bell J.E. Glial and neuronal differentiation in the human fetal brain 9-23weeks of gestation. Neuropathol. Appl. Neurobiol. 1990, 16:193-204.
94. Willsey A.J., Sanders S.J., Li M., Dong S., Tebbenkamp A.T., Muhle R.A., Reilly S.K., Lin L., Fertuzinhos S., Miller J.A., et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 2013, 155:997-1007.
95. Zambon A.C., Gaj S., Ho I., Hanspers K., Vranizan K., Evelo C.T., Conklin B.R., Pico A.R., Salomonis N. GO-Elite: a flexible solution for pathway and ontology over-representation. Bioinformatics 2012, 28:2209-2210.