Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex

Journal of Neuroscience

Volumn 34, Issue 47, 2014, Pages 15587-15600

  Thomsen, Gretchen M ^a   Gowing, Genevieve ^a   Latter, Jessica ^a   Chen, Maximus ^a   Vit, Jean Philippe ^b   Staggenborg, Kevin ^a   Avalos, Pablo ^a   Alkaslasi, Mor ^a   Ferraiuolo, Laura ^c   Likhite, Shibi ^c   Kaspar, Brian K ^c,d   Svendsen, Clive N ^a,b  

^a Board of Governors Regenerative Medicine Institute   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

ALS; Amyotrophic lateral sclerosis; Motor neuron disease; Neurodegenerative disorder; RNAi; SOD1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ELECTROPHYSIOLOGY; BRAIN FUNCTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSFECTION; GENOME ANALYSIS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; LOCOMOTION; MALE; MICROGLIA; MOTOR CORTEX; MOTOR NEURON DISEASE; NEUROANATOMY; NEUROMUSCULAR SYNAPSE; NONHUMAN; PSEUDORABIES HERPETOVIRUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL DEATH; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; MORTALITY; MOUSE; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; FEMALE; GENE KNOCKDOWN TECHNIQUES; HERPESVIRUS 1, SUID; HUMANS; MALE; MICE; MOTOR CORTEX; NEUROMUSCULAR JUNCTION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; SUPEROXIDE DISMUTASE; TRANSFECTION;

EID: 84911408927     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2037-14.2014     Document Type: Article

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