Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons

Journal of Neuroscience

Volumn 35, Issue 3, 2015, Pages 1291-1306

  Toma, Jeremy S ^a   Shettar, Basavaraj C ^a   Chipman, Peter H ^a   Pinto, Devanand M ^d   Borowska, Joanna P ^a   Ichida, Justin K ^b   Fawcett, James P ^a   Zhang, Ying ^a   Eggan, Kevin ^b,c   Rafuse, Victor F ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b HARVARD UNIVERSITY   (United States)

^c Harvard University   (United States)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Electrophysiology; iPS cells; Motoneuron disease; Motoneurons; Proteomics; Stem cells

Indexed keywords

ACTIN RELATED PROTEIN 5; ALCOHOL DEHYDROGENASE; ALLOGRAFT INFLAMMATORY FACTOR 1; ARGINASE 1; ATAXIN 10; BETA GALACTOSIDASE; BETA N ACETYLHEXOSAMINIDASE BETA CHAIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CELL CYCLE PROTEIN 37; COLLAPSIN RESPONSE MEDIATOR PROTEIN 1; EPHRIN RECEPTOR B6; FERRITIN LIGHT CHAIN 1; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FUMARATE HYDRATASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCINE HYDROXYMETHYLTRANSFERASE; INTERSECTIN 2; KININOGEN 1; MEMBRANE PROTEIN; METHYLTESTOSTERONE; MYOSIN VI; NUCLEAR RNA EXPORT FACTOR 7; NUCLEIC ACID BINDING PROTEIN; PROTEIN P63; RNA BINDING PROTEIN 3; SCRAMBLASE 1; TRANSCRIPTION FACTOR LHX3; UBIQUITIN THIOLESTERASE 8; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINC FINGER PROTEIN 382; LIM HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; ATROPHY; CHICK; CHROMATOGRAPHY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL DERIVED MOTONEURON; FLUORESCENCE ACTIVATED CELL SORTING; GASTROCNEMIUS MUSCLE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MASS SPECTROMETRY; MEMBRANE STEADY POTENTIAL; MOUSE; MUSCLE DENERVATION; MUSCLE FIBRIL; NERVE POTENTIAL; NEURAL TUBE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATCH CLAMP TECHNIQUE; PERIPHERAL NERVE INJURY; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; SPINAL CORD; SPINAL CORD MOTONEURON; TIBIAL NERVE; TRANSPLANTATION; UPREGULATION; ANIMAL; CHICK EMBRYO; CYTOLOGY; METABOLISM; MOTONEURON; NERVE FIBER; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; AXONS; CHICK EMBRYO; INDUCED PLURIPOTENT STEM CELLS; LIM-HOMEODOMAIN PROTEINS; MICE; MOTOR NEURONS; MUSCLE, SKELETAL; NEUROGENESIS; NEUROMUSCULAR JUNCTION; PHENOTYPE; PROTEOMICS; TRANSCRIPTION FACTORS;

EID: 84921473271     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2126-14.2015     Document Type: Article

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