메뉴 건너뛰기




Volumn 592, Issue 7, 2014, Pages 1687-1703

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE;

EID: 84897371904     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.265843     Document Type: Article
Times cited : (104)

References (61)
  • 2
    • 78751515661 scopus 로고    scopus 로고
    • A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade
    • Bellingham MC (2011). A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? CNS Neurosci Ther 17, 4-31.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 4-31
    • Bellingham, M.C.1
  • 3
    • 0034786606 scopus 로고    scopus 로고
    • Plateau potentials in sacrocaudal motoneurons of chronic spinal rats, recorded in vitro
    • Bennett DJ, Li Y & Siu M (2001). Plateau potentials in sacrocaudal motoneurons of chronic spinal rats, recorded in vitro. J Neurophysiol 86, 1955-1971.
    • (2001) J Neurophysiol , vol.86 , pp. 1955-1971
    • Bennett, D.J.1    Li, Y.2    Siu, M.3
  • 4
    • 33847017739 scopus 로고    scopus 로고
    • Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis
    • Bories C, Amendola J, Lamotte d'Incamps B & Durand J (2007). Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis. Eur J Neurosci 25, 451-459.
    • (2007) Eur J Neurosci , vol.25 , pp. 451-459
    • Bories, C.1    Amendola, J.2    Lamotte d'Incamps, B.3    Durand, J.4
  • 5
    • 84884539375 scopus 로고    scopus 로고
    • Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats
    • Bouhadfane M, Tazerart S, Moqrich A, Vinay L & Brocard F (2013). Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats. J Neurosci 33, 15626-15641.
    • (2013) J Neurosci , vol.33 , pp. 15626-15641
    • Bouhadfane, M.1    Tazerart, S.2    Moqrich, A.3    Vinay, L.4    Brocard, F.5
  • 6
    • 84897436172 scopus 로고    scopus 로고
    • R package 'sm': nonparametric smoothing methods, version 2.2-4 edn.
    • Bowman A & Azzalini A (2010). R package 'sm': nonparametric smoothing methods, version 2.2-4 edn.
    • (2010)
    • Bowman, A.1    Azzalini, A.2
  • 7
    • 0027409375 scopus 로고
    • Quantitative synaptology of functionally different types of cat medial gastrocnemius alpha-motoneurons
    • Brannstrom T (1993). Quantitative synaptology of functionally different types of cat medial gastrocnemius alpha-motoneurons. J Comp Neurol 330, 439-454.
    • (1993) J Comp Neurol , vol.330 , pp. 439-454
    • Brannstrom, T.1
  • 8
    • 0000076646 scopus 로고
    • Motor units: anatomy, physiology, and functional organization
    • In, ed. Brooks V. American Physiological Society, Bethesda, MD.
    • Burke R (1981). Motor units: anatomy, physiology, and functional organization. In Handbook of Physiology The Nervous System Motor Control, ed. Brooks V. American Physiological Society, Bethesda, MD.
    • (1981) Handbook of Physiology The Nervous System Motor Control
    • Burke, R.1
  • 9
    • 84864066028 scopus 로고    scopus 로고
    • Motor terminal degeneration unaffected by activity changes in SOD1(G93A) mice; a possible role for glycolysis
    • Carrasco DI, Bichler EK, Rich MM, Wang X, Seburn KL & Pinter MJ (2012). Motor terminal degeneration unaffected by activity changes in SOD1(G93A) mice; a possible role for glycolysis. Neurobiol Dis 48, 132-140.
    • (2012) Neurobiol Dis , vol.48 , pp. 132-140
    • Carrasco, D.I.1    Bichler, E.K.2    Rich, M.M.3    Wang, X.4    Seburn, K.L.5    Pinter, M.J.6
  • 10
    • 53149091651 scopus 로고    scopus 로고
    • GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis
    • Carunchio I, Mollinari C, Pieri M, Merlo D & Zona C (2008). GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis. Eur J Neurosci 28, 1275-1285.
    • (2008) Eur J Neurosci , vol.28 , pp. 1275-1285
    • Carunchio, I.1    Mollinari, C.2    Pieri, M.3    Merlo, D.4    Zona, C.5
  • 11
    • 79951991424 scopus 로고    scopus 로고
    • Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis
    • Chang Q & Martin LJ (2011). Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 31, 2815-2827.
    • (2011) J Neurosci , vol.31 , pp. 2815-2827
    • Chang, Q.1    Martin, L.J.2
  • 13
    • 0018391888 scopus 로고
    • Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. IV. Motoneurons innervating slow-twitch (type S) units of the soleus muscle
    • Conradi S, Kellerth JO, Berthold CH & Hammarberg C (1979). Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. IV. Motoneurons innervating slow-twitch (type S) units of the soleus muscle. J Comp Neurol 184, 769-782.
    • (1979) J Comp Neurol , vol.184 , pp. 769-782
    • Conradi, S.1    Kellerth, J.O.2    Berthold, C.H.3    Hammarberg, C.4
  • 15
    • 77951615746 scopus 로고    scopus 로고
    • Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons
    • Elbasiouny SM, Amendola J, Durand J & Heckman CJ (2010). Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons. J Neurosci 30, 5544-5558.
    • (2010) J Neurosci , vol.30 , pp. 5544-5558
    • Elbasiouny, S.M.1    Amendola, J.2    Durand, J.3    Heckman, C.J.4
  • 16
    • 0019822688 scopus 로고
    • Rheobase, input resistance, and motor-unit type in medial gastrocnemius motoneurons in the cat
    • Fleshman JW, Munson JB, Sypert GW & Friedman WA (1981). Rheobase, input resistance, and motor-unit type in medial gastrocnemius motoneurons in the cat. J Neurophysiol 46, 1326-1338.
    • (1981) J Neurophysiol , vol.46 , pp. 1326-1338
    • Fleshman, J.W.1    Munson, J.B.2    Sypert, G.W.3    Friedman, W.A.4
  • 18
    • 0032889649 scopus 로고    scopus 로고
    • Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials
    • Guertin PA & Hounsgaard J (1999). Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials. Neuroscience 88, 353-358.
    • (1999) Neuroscience , vol.88 , pp. 353-358
    • Guertin, P.A.1    Hounsgaard, J.2
  • 20
    • 0021286755 scopus 로고
    • Relations among passive electrical properties of lumbar alpha-motoneurones of the cat
    • Gustafsson B & Pinter MJ (1984). Relations among passive electrical properties of lumbar alpha-motoneurones of the cat. J Physiol 356, 401-431.
    • (1984) J Physiol , vol.356 , pp. 401-431
    • Gustafsson, B.1    Pinter, M.J.2
  • 21
    • 33748580668 scopus 로고    scopus 로고
    • Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats
    • Harvey PJ, Li Y, Li X & Bennett DJ (2006). Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats. J Neurophysiol 96, 1141-1157.
    • (2006) J Neurophysiol , vol.96 , pp. 1141-1157
    • Harvey, P.J.1    Li, Y.2    Li, X.3    Bennett, D.J.4
  • 22
    • 35349025311 scopus 로고    scopus 로고
    • Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
    • Hegedus J, Putman CT & Gordon T (2007). Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 28, 154-164.
    • (2007) Neurobiol Dis , vol.28 , pp. 154-164
    • Hegedus, J.1    Putman, C.T.2    Gordon, T.3
  • 23
    • 48949120504 scopus 로고    scopus 로고
    • Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis
    • Hegedus J, Putman CT, Tyreman N & Gordon T (2008). Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis. J Physiol 586, 3337-3351.
    • (2008) J Physiol , vol.586 , pp. 3337-3351
    • Hegedus, J.1    Putman, C.T.2    Tyreman, N.3    Gordon, T.4
  • 24
    • 79955782892 scopus 로고    scopus 로고
    • Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state
    • Iglesias C, Meunier C, Manuel M, Timofeeva Y, Delestree N & Zytnicki D (2011). Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state. J Neurosci 31, 5829-5840.
    • (2011) J Neurosci , vol.31 , pp. 5829-5840
    • Iglesias, C.1    Meunier, C.2    Manuel, M.3    Timofeeva, Y.4    Delestree, N.5    Zytnicki, D.6
  • 25
    • 74049164709 scopus 로고    scopus 로고
    • Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    • Ilieva H, Polymenidou M & Cleveland DW (2009). Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 187, 761-772.
    • (2009) J Cell Biol , vol.187 , pp. 761-772
    • Ilieva, H.1    Polymenidou, M.2    Cleveland, D.W.3
  • 26
    • 33747166786 scopus 로고    scopus 로고
    • In vitro sacral cord preparation and motoneuron recording from adult mice
    • Jiang MC & Heckman CJ (2006). In vitro sacral cord preparation and motoneuron recording from adult mice. J Neurosci Methods 156, 31-36.
    • (2006) J Neurosci Methods , vol.156 , pp. 31-36
    • Jiang, M.C.1    Heckman, C.J.2
  • 27
    • 72849120555 scopus 로고    scopus 로고
    • Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis
    • Jiang M, Schuster JE, Fu R, Siddique T & Heckman CJ (2009). Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis. J Neurosci 29, 15031-15038.
    • (2009) J Neurosci , vol.29 , pp. 15031-15038
    • Jiang, M.1    Schuster, J.E.2    Fu, R.3    Siddique, T.4    Heckman, C.J.5
  • 28
    • 0020532238 scopus 로고
    • Electron microscopic studies of serially sectioned cat spinal α-motoneurons: V. motoneurons innervating fast-twitch (type FF) units of the gastrocnemius muscle
    • Kellerth JO, Conradi S & Berthold CH (1983). Electron microscopic studies of serially sectioned cat spinal α-motoneurons: V. motoneurons innervating fast-twitch (type FF) units of the gastrocnemius muscle. J Comp Neurol 214, 451-458.
    • (1983) J Comp Neurol , vol.214 , pp. 451-458
    • Kellerth, J.O.1    Conradi, S.2    Berthold, C.H.3
  • 29
    • 15844431408 scopus 로고    scopus 로고
    • + current and its effect on excitability in motoneurones cultured from mutant SOD1 mice
    • + current and its effect on excitability in motoneurones cultured from mutant SOD1 mice. J Physiol 563, 843-854.
    • (2005) J Physiol , vol.563 , pp. 843-854
    • Kuo, J.J.1    Siddique, T.2    Fu, R.3    Heckman, C.J.4
  • 30
    • 33746217759 scopus 로고    scopus 로고
    • Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones
    • Kuo JJ, Lee RH, Zhang L & Heckman CJ (2006). Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones. J Physiol 574, 819-834.
    • (2006) J Physiol , vol.574 , pp. 819-834
    • Kuo, J.J.1    Lee, R.H.2    Zhang, L.3    Heckman, C.J.4
  • 32
    • 0035186745 scopus 로고    scopus 로고
    • Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing
    • Lee RH & Heckman CJ (2001). Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing. J Neurophysiol 85, 472-475.
    • (2001) J Neurophysiol , vol.85 , pp. 472-475
    • Lee, R.H.1    Heckman, C.J.2
  • 33
    • 80054720861 scopus 로고    scopus 로고
    • Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment
    • Manuel M & Heckman CJ (2011). Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment? J Neurosci 31, 15188-15194.
    • (2011) J Neurosci , vol.31 , pp. 15188-15194
    • Manuel, M.1    Heckman, C.J.2
  • 34
    • 84874139665 scopus 로고    scopus 로고
    • Simultaneous intracellular recording of a lumbar motoneuron and the force produced by its motor unit in the adult mouse in vivo
    • Manuel M & Heckman CJ (2012a). Simultaneous intracellular recording of a lumbar motoneuron and the force produced by its motor unit in the adult mouse in vivo. J Vis Exp, e4312.
    • (2012) J Vis Exp
    • Manuel, M.1    Heckman, C.J.2
  • 35
    • 84897388659 scopus 로고    scopus 로고
    • Single motor unit properties in SOD1 mice
    • In Society for Neuroscience, 2012. Online, New Orleans, LA.
    • Manuel M & Heckman CJ (2012b). Single motor unit properties in SOD1 mice. In Program No 15510 2012 Neuroscience Meeting Planner. Society for Neuroscience, 2012. Online, New Orleans, LA.
    • (2012) Program No 15510 2012 Neuroscience Meeting Planner
    • Manuel, M.1    Heckman, C.J.2
  • 36
    • 70349123549 scopus 로고    scopus 로고
    • Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons
    • Manuel M, Iglesias C, Donnet M, Leroy F, Heckman CJ & Zytnicki D (2009). Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons. J Neurosci 29, 11246-11256.
    • (2009) J Neurosci , vol.29 , pp. 11246-11256
    • Manuel, M.1    Iglesias, C.2    Donnet, M.3    Leroy, F.4    Heckman, C.J.5    Zytnicki, D.6
  • 37
    • 84870487196 scopus 로고    scopus 로고
    • NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons
    • Manuel M, Li Y, Elbasiouny SM, Murray K, Griener A, Heckman CJ & Bennett DJ (2012). NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons. J Neurophysiol 108, 2991-2998.
    • (2012) J Neurophysiol , vol.108 , pp. 2991-2998
    • Manuel, M.1    Li, Y.2    Elbasiouny, S.M.3    Murray, K.4    Griener, A.5    Heckman, C.J.6    Bennett, D.J.7
  • 38
    • 84875672696 scopus 로고    scopus 로고
    • Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of amyotrophic lateral sclerosis
    • Martin E, Cazenave W, Cattaert D & Branchereau P (2013). Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 54, 116-126.
    • (2013) Neurobiol Dis , vol.54 , pp. 116-126
    • Martin, E.1    Cazenave, W.2    Cattaert, D.3    Branchereau, P.4
  • 39
    • 0029609505 scopus 로고
    • Potassium currents in motoneurones
    • McLarnon JG (1995). Potassium currents in motoneurones. Prog Neurobiol 47, 513-531.
    • (1995) Prog Neurobiol , vol.47 , pp. 513-531
    • McLarnon, J.G.1
  • 40
    • 78149482855 scopus 로고    scopus 로고
    • Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents
    • Meehan CF, Moldovan M, Marklund SL, Graffmo KS, Nielsen JB & Hultborn H (2010). Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents. Acta Physiol (Oxf) 200, 361-376.
    • (2010) Acta Physiol (Oxf) , vol.200 , pp. 361-376
    • Meehan, C.F.1    Moldovan, M.2    Marklund, S.L.3    Graffmo, K.S.4    Nielsen, J.B.5    Hultborn, H.6
  • 41
    • 22744438957 scopus 로고    scopus 로고
    • Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones
    • Miles GB, Dai Y & Brownstone RM (2005). Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones. J Physiol 566, 519-532.
    • (2005) J Physiol , vol.566 , pp. 519-532
    • Miles, G.B.1    Dai, Y.2    Brownstone, R.M.3
  • 43
    • 72749112308 scopus 로고    scopus 로고
    • Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice
    • Pambo-Pambo A, Durand J & Gueritaud JP (2009). Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice. J Neurophysiol 102, 3627-3642.
    • (2009) J Neurophysiol , vol.102 , pp. 3627-3642
    • Pambo-Pambo, A.1    Durand, J.2    Gueritaud, J.P.3
  • 46
    • 33344462702 scopus 로고    scopus 로고
    • Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
    • Pun S, Santos AF, Saxena S, Xu L & Caroni P (2006). Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nat Neurosci 9, 408-419.
    • (2006) Nat Neurosci , vol.9 , pp. 408-419
    • Pun, S.1    Santos, A.F.2    Saxena, S.3    Xu, L.4    Caroni, P.5
  • 47
    • 79955421221 scopus 로고    scopus 로고
    • Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis
    • Quinlan KA, Schuster JE, Fu R, Siddique T & Heckman CJ (2011). Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis. J Physiol 589, 2245-2260.
    • (2011) J Physiol , vol.589 , pp. 2245-2260
    • Quinlan, K.A.1    Schuster, J.E.2    Fu, R.3    Siddique, T.4    Heckman, C.J.5
  • 48
    • 84863304598 scopus 로고    scopus 로고
    • R Development Core Team. R Foundation for Statistical Computing, Vienna, Austria.
    • R Development Core Team (2010). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria.
    • (2010) R: A Language and Environment for Statistical Computing
  • 49
    • 0346156083 scopus 로고    scopus 로고
    • Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis
    • Rao SD & Weiss JH (2004). Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci 27, 17-23.
    • (2004) Trends Neurosci , vol.27 , pp. 17-23
    • Rao, S.D.1    Weiss, J.H.2
  • 52
    • 33746603602 scopus 로고    scopus 로고
    • Serotonergic mechanisms in amyotrophic lateral sclerosis
    • Sandyk R (2006). Serotonergic mechanisms in amyotrophic lateral sclerosis. Int J Neurosci 116, 775-826.
    • (2006) Int J Neurosci , vol.116 , pp. 775-826
    • Sandyk, R.1
  • 53
    • 4143079087 scopus 로고    scopus 로고
    • Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies
    • Sekerli M, Del Negro CA, Lee RH & Butera RJ (2004). Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies. IEEE Trans Biomed Eng 51, 1665-1672.
    • (2004) IEEE Trans Biomed Eng , vol.51 , pp. 1665-1672
    • Sekerli, M.1    Del Negro, C.A.2    Lee, R.H.3    Butera, R.J.4
  • 54
    • 78650017783 scopus 로고    scopus 로고
    • Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis
    • Sunico CR, Dominguez G, Garcia-Verdugo JM, Osta R, Montero F & Moreno-Lopez B (2011). Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis. Brain Pathol 21, 1-15.
    • (2011) Brain Pathol , vol.21 , pp. 1-15
    • Sunico, C.R.1    Dominguez, G.2    Garcia-Verdugo, J.M.3    Osta, R.4    Montero, F.5    Moreno-Lopez, B.6
  • 55
    • 79952233317 scopus 로고    scopus 로고
    • Genetic rodent models of amyotrophic lateral sclerosis
    • Van Den Bosch L (2011). Genetic rodent models of amyotrophic lateral sclerosis. J Biomed Biotechnol 2011, 348765.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 348765
    • Van Den Bosch, L.1
  • 56
    • 58149173426 scopus 로고    scopus 로고
    • Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis
    • van Zundert B, Peuscher MH, Hynynen M, Chen A, Neve RL, Brown RH, Jr., Constantine-Paton M & Bellingham MC (2008). Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis. J Neurosci 28, 10864-10874.
    • (2008) J Neurosci , vol.28 , pp. 10864-10874
    • van Zundert, B.1    Peuscher, M.H.2    Hynynen, M.3    Chen, A.4    Neve, R.L.5    Brown Jr, R.H.6    Constantine-Paton, M.7    Bellingham, M.C.8
  • 57
    • 23944465642 scopus 로고    scopus 로고
    • 2+, mitochondria and selective motoneuron vulnerability: implications for ALS
    • 2+, mitochondria and selective motoneuron vulnerability: implications for ALS. Trends Neurosci 28, 494-500.
    • (2005) Trends Neurosci , vol.28 , pp. 494-500
    • von Lewinski, F.1    Keller, B.U.2
  • 58
    • 44949243975 scopus 로고    scopus 로고
    • Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis
    • Vucic S, Nicholson GA & Kiernan MC (2008). Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain 131, 1540-1550.
    • (2008) Brain , vol.131 , pp. 1540-1550
    • Vucic, S.1    Nicholson, G.A.2    Kiernan, M.C.3
  • 59
    • 0029150201 scopus 로고
    • Non-parametric analysis of covariance
    • Young S & Bowman A (1995). Non-parametric analysis of covariance. Biometrics 51, 920-931.
    • (1995) Biometrics , vol.51 , pp. 920-931
    • Young, S.1    Bowman, A.2
  • 60
    • 0021816236 scopus 로고
    • Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat
    • Zengel JE, Reid SA, Sypert GW & Munson JB (1985). Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat. J Neurophysiol 53, 1323-1344.
    • (1985) J Neurophysiol , vol.53 , pp. 1323-1344
    • Zengel, J.E.1    Reid, S.A.2    Sypert, G.W.3    Munson, J.B.4
  • 61
    • 33751542967 scopus 로고    scopus 로고
    • Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis
    • Zona C, Pieri M & Carunchio I (2006). Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis. J Neurophysiol 96, 3314-3322.
    • (2006) J Neurophysiol , vol.96 , pp. 3314-3322
    • Zona, C.1    Pieri, M.2    Carunchio, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.