Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

Cell Stem Cell

Volumn 17, Issue 6, 2015, Pages 705-718

  Mertens, Jerome ^a   Paquola, Apuã C M ^a   Ku, Manching ^a   Hatch, Emily ^a   Böhnke, Lena ^a   Ladjevardi, Shauheen ^a   McGrath, Sean ^a   Campbell, Benjamin ^a   Lee, Hyungjun ^a   Herdy, Joseph R ^a   Gonçalves, J Tiago ^a   Toda, Tomohisa ^a   Kim, Yongsung ^a   Winkler, Jürgen ^b   Yao, Jun ^c   Hetzer, Martin W ^a   Gage, Fred H ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; NUCLEOPORIN; PROTEIN RANBP17; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; NERVE CELL ADHESION MOLECULE; RAN PROTEIN; RANGTP-BINDING PROTEIN 17; TRANSCRIPTOME;

ARTICLE; CELL AGING; CELLULAR PARAMETERS; FIBROBLAST; FUNCTIONAL DISEASE; GENE EXPRESSION; HUMAN; HUMAN CELL; NERVE CELL; NUCLEAR PORE COMPLEX; NUCLEAR REPROGRAMMING; NUCLEOCYTOPLASMIC COMPARTMENTALIZATION; PRIORITY JOURNAL; RNA SEQUENCE; TRANSCRIPTOMICS; ADOLESCENT; ADULT; AGED; AGING; CELL NUCLEUS; CELL SEPARATION; CHILD; CYTOLOGY; CYTOPLASM; FLOW CYTOMETRY; INDUCED PLURIPOTENT STEM CELL; INFANT; METABOLISM; MIDDLE AGED; NEWBORN; PRESCHOOL CHILD; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CELL NUCLEUS; CELL SEPARATION; CELLULAR REPROGRAMMING; CHILD; CHILD, PRESCHOOL; CYTOPLASM; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INFANT; INFANT, NEWBORN; MIDDLE AGED; NEURAL CELL ADHESION MOLECULES; NEURONS; RAN GTP-BINDING PROTEIN; TRANSCRIPTOME; YOUNG ADULT;

EID: 84951962754     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.09.001     Document Type: Article

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