Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene

Developmental Biology

Volumn 257, Issue 1, 2003, Pages 1-13

  Aota, Shin Ichi ^a   Nakajima, Noboru ^a   Sakamoto, Ruriko ^a   Watanabe, Sonoe ^a   Ibaraki, Nobuhiro ^b   Okazaki, Kenji ^a  

^a BIOMOL ENG RESEARCH INSTITUTE   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

DNA binding protein; Gene expression; HMG domain; Lens development; Paired domain; Placode formation; Sequence recognition; Tissue specific enhancer; Transcription factor

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOREGULATION; CIS ISOMER; COMPLEX FORMATION; CONTROLLED STUDY; CORNEA; ECTODERM; EMBRYO DEVELOPMENT; ENHANCER REGION; EYE DEVELOPMENT; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; LENS; MOLECULAR RECOGNITION; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; REPORTER GENE; STRUCTURE ANALYSIS; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION;

VERTEBRATA;

EID: 0037403778     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0012-1606(03)00058-7     Document Type: Article

References (46)

1. Ashery-Padan R., Marquardt T., Zhou X., Gruss P. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 14:2000;2701-2711.
2. Baker C.V., Bronner-Fraser M. Vertebrate cranial placodes. I. embryonic induction. Dev. Biol. 232:2001;1-61.
3. Boer P.H., Potten H., Adra C.N., Jardine K., Mullhofer G., McBurney M.W. Polymorphisms in the coding and noncoding regions of murine Pgk-1 alleles. Biochem. Genet. 28:1990;299-308.
4. Bondurand N., Pingault V., Goerich D.E., Lemort N., Sock E., Caignec C.L., Wegner M., Goossens M. Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome. Hum. Mol. Genet. 9:2000;1907-1917.
5. Callaerts P., Halder G., Gehring W.J. PAX-6 in development and evolution. Annu. Rev. Neurosci. 20:1997;483-532.
6. Chow R.L., Altmann C.R., Lang R.A., Hemmati-Brivanlou A. Pax6 induces ectopic eyes in a vertebrate. Development. 126:1999;4213-4222.
7. Collinson J.M., Hill R.E., West J.D. Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development. 127:2000;945-956.
8. Cvekl A., Piatigorsky J. Lens development and crystallin gene expression many roles for Pax-6 . Bioessays. 18:1996;621-630.
9. Cvekl A., Sax C.M., Li X., McDermott J.B., Piatigorsky J. Pax-6 and lens-specific transcription of the chicken δ1-crystallin gene. Proc. Natl. Acad. Sci. USA. 92:1995;4681-4685.
10. Czerny T., Busslinger M. DNA-binding and transactivation properties of Pax-6 three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5) . Mol. Cell. Biol. 15:1995;2858-2871.
11. Czerny T., Schaffner G., Busslinger M. DNA sequence recognition by Pax proteins bipartite structure of the paired domain and its binding site . Genes Dev. 7:1993;2048-2061.
12. Denny P., Swift S., Connor F., Ashworth A. An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. EMBO J. 11:1992;3705-3712.
13. Dimanlig P.V., Faber S.C., Auerbach W., Makarenkova H.P., Lang R.A. The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development. 128:2001;4415-4424.
14. Epstein J., Cai J., Glaser T., Jepeal L., Maas R. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269:1994;8355-8361.
15. Epstein J.A., Glaser T., Cai J., Jepeal L., Walton D.S., Maas R.L. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev. 8:1994;2022-2034.
16. Grainger R.M. Embryonic lens induction shedding light on vertebrate tissue determination . Trends Genet. 8:1992;349-355.
17. Grindley J.C., Davidson D.R., Hill R.E. The role of Pax-6 in eye and nasal development. Development. 121:1995;1433-1442.
18. Halder G., Callaerts P., Gehring W.J. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science. 267:1995;1788-1792.
19. Hill R.E., Favor J., Hogan B.L., Ton C.C., Saunders G.F., Hanson I.M., Prosser J., Jordan T., Hastie N.D., van Heyningen V. Mouse Small eye results from mutations in a paired-like homeobox-containing gene. Nature. 354:1991;522-525.
20. Hogan B.L., Hirst E.M., Horsburgh G., Hetherington C.M. Small eye (Sey) a mouse model for the genetic analysis of craniofacial abnormalities . Development. 103:1988;115-119.
21. Ibaraki N., Chen S.C., Lin L.R., Okamoto H., Pipas J.M., Reddy V.N. Human lens epithelial cell line. Exp. Eye Res. 67:1998;577-585.
22. Kamachi Y., Uchikawa M., Kondoh H. Pairing SOX off with partners in the regulation of embryonic development . Trends Genet. 16:2000;182-187.
23. Kamachi Y., Uchikawa M., Tanouchi A., Sekido R., Kondoh H. Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev. 15:2001;1272-1286.
24. Kammandel B., Chowdhury K., Stoykova A., Aparicio S., Brenner S., Gruss P. Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev. Biol. 205:1999;79-97.
25. Kawakami A., Kimura-Kawakami M., Nomura T., Fujisawa H. Distributions of PAX6 and PAX7 proteins suggest their involvement in both early and late phases of chick brain development. Mech. Dev. 66:1997;119-130.
26. Kitamura K., Aota S., Sakamoto R., Yoshikawa S., Okazaki K. Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation. Blood. 95:2000;3371-3379.
27. Köster R.W., Kuhnlein R.P., Wittbrodt J. Ectopic Sox3 activity elicits sensory placode formation. Mech. Dev. 95:2000;175-187.
28. Kozmik Z., Czerny T., Busslinger M. Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8. EMBO J. 16:1997;6793-6803.
29. Lang D., Chen F., Milewski R., Li J., Lu M.M., Epstein J.A. Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret. J. Clin. Invest. 106:2000;963-971.
30. Lennon G., Auffray C., Polymeropoulos M., Soares M.B. The I.M.A.G.E. consortium an integrated molecular analysis of genomes and their expression . Genomics. 33:1996;151-152.
31. Li H.S., Yang J.M., Jacobson R.D., Pasko D., Sundin O. Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate implications for stepwise determination of the lens . Dev. Biol. 162:1994;181-194.
32. Mansouri A., Goudreau G., Gruss P. Pax genes and their role in organogenesis. Cancer Res. 59:1999;1707s-1710s.
33. Oe T., Nakajo N., Katsuragi Y., Okazaki K., Sagata N. Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes. Dev. Biol. 229:2001;250-261.
34. Okazaki K., Sagata N. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and auguments its transformation activity in NIH 3T3 cells. EMBO J. 14:1995;5048-5059.
35. Plaza S., Dozier C., Saule S. Quail Pax-6 (Pax-qnr) encodes a transcription factor able to bind and trans-activate its own promoter. Cell Growth Differ. 4:1993;1041-1050.
36. Plaza S., Saule S., Dozier C. High conservation of cis-regulatory elements between quail and human for the Pax-6 gene. Dev. Genes Evol. 209:1999;165-173.
37. Potterf S.B., Furumura M., Dunn K.J., Arnheiter H., Pavan W.J. Transcription factor hierarchy in Waardenburg syndrome regulation of MITF expression by SOX10 and PAX3 . Hum. Genet. 107:2000;1-6.
38. Quinn J.C., West J.D., Hill R.E. Multiple functions for Pax6 in mouse eye and nasal development. Genes Dev. 10:1996;435-446.
39. Schedl A., Ross A., Lee M., Engelkamp D., Rashbass P., van Heyningen V., Hastie N.D. Influence of PAX6 gene dosage on development overexpression causes severe eye abnormalities . Cell. 86:1996;71-82.
40. Singh S., Mishra R., Arango N.A., Deng J.M., Behringer R.R., Saunders G.F. Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform. Proc. Natl. Acad. Sci. USA. 99:2002;6812-6815.
41. Treisman J. A conserved blueprint for the eye. BioEssays. 21:1999;843-850.
42. Uchikawa M., Kamachi Y., Kondoh H. Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors their expression during embryonic organogenesis of the chicken . Mech. Dev. 84:1999;103-120.
43. van Raamsdonk C.D., Tilghman S.M. Dosage requirement and allelic expression of PAX6 during lens placode formation. Development. 127:2000;5439-5448.
44. Walther C., Guenet J.L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P. Pax a murine multigene family of paired box-containing genes . Genomics. 11:1991;424-434.
45. Williams S.C., Altmann C.R., Chow R.L., Hemmati-Brivanlou A., Lang R.A. A highly conserved lens transcriptional control element from the Pax-6 gene. Mech. Dev. 73:1998;225-229.
46. Xu P.X., Zhang X., Heaney S., Yoon A., Michelson A.M., Maas R.L. Regulation of Pax6 expression is conserved between mice and flies. Development. 126:1999;383-395.