메뉴 건너뛰기




Volumn 33, Issue 1, 2015, Pages 89-96

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; CYTOLOGY; DIAGNOSIS; MOLECULES; SENSORY ANALYSIS; STEM CELLS;

EID: 84925780045     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3049     Document Type: Article
Times cited : (266)

References (48)
  • 1
    • 84885850258 scopus 로고    scopus 로고
    • Opportunities and challenges of pluripotent stem cell neurodegenerative disease models
    • Sandoe, J., Eggan, K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat. Neurosci. 16, 780-789 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 780-789
    • Sandoe, J.1    Eggan, K.2
  • 2
    • 84878852415 scopus 로고    scopus 로고
    • Modeling human disease with pluripotent stem cells: From genome association to function
    • Merkle, F.T., Eggan, K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell 12, 656-668 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 656-668
    • Merkle, F.T.1    Eggan, K.2
  • 3
  • 4
    • 79952070300 scopus 로고    scopus 로고
    • Programming embryonic stem cells to neuronal subtypes
    • Peljto, M., Wichterle, H. Programming embryonic stem cells to neuronal subtypes. Curr. Opin. Neurobiol. 21, 43-51 (2011).
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 43-51
    • Peljto, M.1    Wichterle, H.2
  • 5
    • 35548945282 scopus 로고    scopus 로고
    • Patterning and axon guidance of cranial motor neurons
    • Guthrie, S. Patterning and axon guidance of cranial motor neurons. Nat. Rev. Neurosci. 8, 859-871 (2007).
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 859-871
    • Guthrie, S.1
  • 7
    • 33747353254 scopus 로고    scopus 로고
    • An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity
    • Nordström, U., Maier, E., Jessell, T.M., Edlund, T. An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity. PLoS Biol. 4, e252 (2006).
    • (2006) PLoS Biol. , vol.4 , pp. e252
    • Nordström, U.1    Maier, E.2    Jessell, T.M.3    Edlund, T.4
  • 8
    • 84872058490 scopus 로고    scopus 로고
    • Accelerated high-yield generation of limb-innervating motor neurons from human stem cells
    • Amoroso, M.W. et al. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J. Neurosci. 33, 574-586 (2013).
    • (2013) J. Neurosci. , vol.33 , pp. 574-586
    • Amoroso, M.W.1
  • 9
    • 84902134581 scopus 로고    scopus 로고
    • Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons
    • Chen, H. et al. Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14, 796-809 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 796-809
    • Chen, H.1
  • 10
    • 13844271605 scopus 로고    scopus 로고
    • Specification of motoneurons from human embryonic stem cells
    • Li, X.J. et al. Specification of motoneurons from human embryonic stem cells. Nat. Biotechnol. 23, 215-221 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 215-221
    • Li, X.J.1
  • 11
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle, H., Lieberam, I., Porter, J.A., Jessell, T.M. Directed differentiation of embryonic stem cells into motor neurons. Cell 110, 385-397 (2002).
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 12
    • 62149125434 scopus 로고    scopus 로고
    • Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    • Chambers, S.M. et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275-280 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 275-280
    • Chambers, S.M.1
  • 13
    • 84863094725 scopus 로고    scopus 로고
    • Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    • Kirkeby, A. et al. Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Reports 1, 703-714 (2012).
    • (2012) Cell Reports , vol.1 , pp. 703-714
    • Kirkeby, A.1
  • 14
    • 84925043926 scopus 로고    scopus 로고
    • NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency
    • Mendjan, S. et al. NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency. Cell Stem Cell 15, 310-325 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 310-325
    • Mendjan, S.1
  • 15
    • 79958090845 scopus 로고    scopus 로고
    • A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3
    • Bone, H.K., Nelson, A.S., Goldring, C.E., Tosh, D., Welham, M.J. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J. Cell Sci. 124, 1992-2000 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 1992-2000
    • Bone, H.K.1    Nelson, A.S.2    Goldring, C.E.3    Tosh, D.4    Welham, M.J.5
  • 16
    • 38349062515 scopus 로고    scopus 로고
    • Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
    • Elkabetz, Y. et al. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 22, 152-165 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 152-165
    • Elkabetz, Y.1
  • 17
    • 77952416762 scopus 로고    scopus 로고
    • Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo
    • Borghese, L. et al. Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo. Stem Cells 28, 955-964 (2010).
    • (2010) Stem Cells , vol.28 , pp. 955-964
    • Borghese, L.1
  • 18
    • 84883445886 scopus 로고    scopus 로고
    • Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity
    • Mazzoni, E.O. et al. Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nat. Neurosci. 16, 1219-1227 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1219-1227
    • Mazzoni, E.O.1
  • 19
    • 0038386025 scopus 로고    scopus 로고
    • Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors
    • Lee, S.K., Pfaff, S.L. Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 38, 731-745 (2003).
    • (2003) Neuron , vol.38 , pp. 731-745
    • Lee, S.K.1    Pfaff, S.L.2
  • 20
    • 47749149893 scopus 로고    scopus 로고
    • Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1
    • Dasen, J.S., De Camilli, A., Wang, B., Tucker, P.W., Jessell, T.M. Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell 134, 304-316 (2008).
    • (2008) Cell , vol.134 , pp. 304-316
    • Dasen, J.S.1    De Camilli, A.2    Wang, B.3    Tucker, P.W.4    Jessell, T.M.5
  • 21
    • 4544251998 scopus 로고    scopus 로고
    • Functional properties of motoneurons derived from mouse embryonic stem cells
    • Miles, G.B. et al. Functional properties of motoneurons derived from mouse embryonic stem cells. J. Neurosci. 24, 7848-7858 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 7848-7858
    • Miles, G.B.1
  • 22
    • 0034053353 scopus 로고    scopus 로고
    • Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b
    • Pattyn, A., Hirsch, M., Goridis, C., Brunet, J.F. Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b. Development 127, 1349-1358 (2000).
    • (2000) Development , vol.127 , pp. 1349-1358
    • Pattyn, A.1    Hirsch, M.2    Goridis, C.3    Brunet, J.F.4
  • 23
    • 84890819378 scopus 로고    scopus 로고
    • Detailed expression analysis of regulatory genes in the early developing human neural tube
    • Marklund, U. et al. Detailed expression analysis of regulatory genes in the early developing human neural tube. Stem Cells Dev. 23, 5-15 (2014).
    • (2014) Stem Cells Dev. , vol.23 , pp. 5-15
    • Marklund, U.1
  • 24
    • 33846146039 scopus 로고    scopus 로고
    • T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
    • Song, M.R. et al. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development 133, 4945-4955 (2006).
    • (2006) Development , vol.133 , pp. 4945-4955
    • Song, M.R.1
  • 25
    • 78650720264 scopus 로고    scopus 로고
    • Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression
    • Sturgeon, K. et al. Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression. Development 138, 65-74 (2011).
    • (2011) Development , vol.138 , pp. 65-74
    • Sturgeon, K.1
  • 26
    • 0029959163 scopus 로고    scopus 로고
    • Patterning the vertebrate neuraxis
    • Lumsden, A., Krumlauf, R. Patterning the vertebrate neuraxis. Science 274, 1109-1115 (1996).
    • (1996) Science , vol.274 , pp. 1109-1115
    • Lumsden, A.1    Krumlauf, R.2
  • 27
    • 67949095557 scopus 로고    scopus 로고
    • Hox networks and the origins of motor neuron diversity
    • Dasen, J.S., Jessell, T.M. Hox networks and the origins of motor neuron diversity. Curr. Top. Dev. Biol. 88, 169-200 (2009).
    • (2009) Curr. Top. Dev. Biol. , vol.88 , pp. 169-200
    • Dasen, J.S.1    Jessell, T.M.2
  • 28
    • 84883463220 scopus 로고    scopus 로고
    • Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals
    • Mazzoni, E.O. et al. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nat. Neurosci. 16, 1191-1198 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1191-1198
    • Mazzoni, E.O.1
  • 29
    • 34250804728 scopus 로고    scopus 로고
    • Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord
    • Skromne, I., Thorsen, D., Hale, M., Prince, V.E., Ho, R.K. Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development 134, 2147-2158 (2007).
    • (2007) Development , vol.134 , pp. 2147-2158
    • Skromne, I.1    Thorsen, D.2    Hale, M.3    Prince, V.E.4    Ho, R.K.5
  • 30
    • 77953766440 scopus 로고    scopus 로고
    • Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: The role of negative feedback
    • Ribes, V., Briscoe, J. Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. Cold Spring Harb. Perspect. Biol. 1, a002014 (2009).
    • (2009) Cold Spring Harb. Perspect. Biol. , vol.1 , pp. a002014
    • Ribes, V.1    Briscoe, J.2
  • 32
    • 0031046759 scopus 로고    scopus 로고
    • Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D
    • Varela-Echavarriá, A., Tucker, A., Puschel, A.W., Guthrie, S. Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D. Neuron 18, 193-207 (1997).
    • (1997) Neuron , vol.18 , pp. 193-207
    • Varela-Echavarriá, A.1    Tucker, A.2    Puschel, A.W.3    Guthrie, S.4
  • 33
    • 55249095378 scopus 로고    scopus 로고
    • Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord
    • Masuda, T. et al. Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord. J. Neurosci. 28, 10380-10385 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 10380-10385
    • Masuda, T.1
  • 34
    • 68549094657 scopus 로고    scopus 로고
    • Stem cells, signals and vertebrate body axis extension
    • Wilson, V., Olivera-Martinez, I., Storey, K.G. Stem cells, signals and vertebrate body axis extension. Development 136, 1591-1604 (2009).
    • (2009) Development , vol.136 , pp. 1591-1604
    • Wilson, V.1    Olivera-Martinez, I.2    Storey, K.G.3
  • 35
    • 84908425180 scopus 로고    scopus 로고
    • In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity
    • Gouti, M. et al. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PLoS Biol. 12, e1001937 (2014).
    • (2014) PLoS Biol. , vol.12 , pp. e1001937
    • Gouti, M.1
  • 36
    • 69949184406 scopus 로고    scopus 로고
    • Redefining the progression of lineage segregations during mammalian embryogenesis by clonal analysis
    • Tzouanacou, E., Wegener, A., Wymeersch, F.J., Wilson, V., Nicolas, J.F. Redefining the progression of lineage segregations during mammalian embryogenesis by clonal analysis. Dev. Cell 17, 365-376 (2009).
    • (2009) Dev. Cell , vol.17 , pp. 365-376
    • Tzouanacou, E.1    Wegener, A.2    Wymeersch, F.J.3    Wilson, V.4    Nicolas, J.F.5
  • 37
    • 84867141403 scopus 로고    scopus 로고
    • Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse
    • Bialecka, M. et al. Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse. Dev. Biol. 371, 227-234 (2012).
    • (2012) Dev. Biol. , vol.371 , pp. 227-234
    • Bialecka, M.1
  • 38
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
    • Kriks, S. et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 480, 547-551 (2011).
    • (2011) Nature , vol.480 , pp. 547-551
    • Kriks, S.1
  • 39
    • 84864353544 scopus 로고    scopus 로고
    • Specification of midbrain dopamine neurons from primate pluripotent stem cells
    • Xi, J. et al. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 30, 1655-1663 (2012).
    • (2012) Stem Cells , vol.30 , pp. 1655-1663
    • Xi, J.1
  • 40
    • 77954137428 scopus 로고    scopus 로고
    • What can pluripotent stem cells teach us about neurodegenerative diseases?
    • Wichterle, H., Przedborski, S. What can pluripotent stem cells teach us about neurodegenerative diseases? Nat. Neurosci. 13, 800-804 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 800-804
    • Wichterle, H.1    Przedborski, S.2
  • 41
    • 42549117636 scopus 로고    scopus 로고
    • Brown-Vialetto-Van Laere syndrome
    • Sathasivam, S. Brown-Vialetto-Van Laere syndrome. Orphanet J. Rare Dis. 3, 9 (2008).
    • (2008) Orphanet J. Rare Dis. , vol.3 , pp. 9
    • Sathasivam, S.1
  • 42
    • 0033518387 scopus 로고    scopus 로고
    • Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice
    • Nimchinsky, E.A. et al. Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice. J. Comp. Neurol. 416, 112-125 (2000).
    • (2000) J. Comp. Neurol. , vol.416 , pp. 112-125
    • Nimchinsky, E.A.1
  • 43
    • 79954418381 scopus 로고    scopus 로고
    • Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy
    • Marteyn, A. et al. Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy. Cell Stem Cell 8, 434-444 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 434-444
    • Marteyn, A.1
  • 44
    • 56549096129 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
    • Di Giorgio, F.P., Boulting, G.L., Bobrowicz, S., Eggan, K.C. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 3, 637-648 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 637-648
    • Di Giorgio, F.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 45
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 46
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920 (2007).
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 47
    • 57449118907 scopus 로고    scopus 로고
    • Human embryonic stem cells reveal recurrent genomic instability at 20q11.21
    • Lefort, N. et al. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Nat. Biotechnol. 26, 1364-1366 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1364-1366
    • Lefort, N.1
  • 48
    • 84856248920 scopus 로고    scopus 로고
    • Concentration dependent requirement for local protein synthesis in motor neuron subtype specific response to axon guidance cues
    • Nédelec, P.M., Shi, P., Amoroso, M.W., Kam, L.C., Wichterle, H. Concentration dependent requirement for local protein synthesis in motor neuron subtype specific response to axon guidance cues. J. Neurosci. 32, 1496-1506 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 1496-1506
    • Nédelec, P.M.1    Shi, P.2    Amoroso, M.W.3    Kam, L.C.4    Wichterle, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.