메뉴 건너뛰기




Volumn 9, Issue 2, 2013, Pages 65-74

The puzzling case of hyperexcitability in amyotrophic lateral sclerosis

Author keywords

Amyotrophic lateral sclerosis; Corticomotoneuron; Gamma aminobutyric acid; Hyperexcitability; Interneuron

Indexed keywords


EID: 84876029455     PISSN: 17386586     EISSN: 20055013     Source Type: Journal    
DOI: 10.3988/jcn.2013.9.2.65     Document Type: Article
Times cited : (105)

References (92)
  • 2
    • 67349272036 scopus 로고    scopus 로고
    • Hyperexcitability, persistent Na+ conductances and neurodegeneration in amyotrophic lateral sclerosis
    • Kiernan MC. Hyperexcitability, persistent Na+ conductances and neurodegeneration in amyotrophic lateral sclerosis. Exp Neurol 2009; 218:1-4.
    • (2009) Exp Neurol , vol.218 , pp. 1-4
    • Kiernan, M.C.1
  • 3
    • 0141780610 scopus 로고    scopus 로고
    • Alphabetic list of terms with definitions
    • Section I: Alphabetic list of terms with definitions. Muscle Nerve 2001; 24:S5-S28.
    • (2001) Muscle Nerve , vol.24
    • Section, I.1
  • 4
    • 39749131694 scopus 로고    scopus 로고
    • Firing pattern of fasciculations in ALS: Evidence for axonal and neuronal origin
    • Kleine BU, Stegeman DF, Schelhaas HJ, Zwarts MJ. Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin. Neurology 2008;70:353-359.
    • (2008) Neurology , vol.70 , pp. 353-359
    • Kleine, B.U.1    Stegeman, D.F.2    Schelhaas, H.J.3    Zwarts, M.J.4
  • 5
    • 84860917551 scopus 로고    scopus 로고
    • Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis?
    • Swash M. Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis? J Neurol Neurosurg Psychiatry 2012;83: 659-662.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 659-662
    • Swash, M.1
  • 6
    • 0031031268 scopus 로고    scopus 로고
    • Ultrasonographic assessment of the prevalence of fasciculations in lesions of the peripheral nervous system
    • Scheel AK, Toepfer M, Kunkel M, Finkenstaedt M, Reimers CD. Ultrasonographic assessment of the prevalence of fasciculations in lesions of the peripheral nervous system. J Neuroimaging 1997;7:23-27.
    • (1997) J Neuroimaging , vol.7 , pp. 23-27
    • Scheel, A.K.1    Toepfer, M.2    Kunkel, M.3    Finkenstaedt, M.4    Reimers, C.D.5
  • 8
    • 0029144351 scopus 로고
    • Motor neuron disease. Studies of the corticospinal excitation of single motor neurons by magnetic brain stimulation
    • Mills KR. Motor neuron disease. Studies of the corticospinal excitation of single motor neurons by magnetic brain stimulation. Brain 1995; 118:971-982.
    • (1995) Brain , vol.118 , pp. 971-982
    • Mills, K.R.1
  • 9
    • 0034030442 scopus 로고    scopus 로고
    • Neurophysiological features of fasciculation potentials evoked by transcranial magnetic stimulation in amyotrophic lateral sclerosis
    • de Carvalho M, Miranda PC, Lourdes Sales Luís M, Ducla-Soares E. Neurophysiological features of fasciculation potentials evoked by transcranial magnetic stimulation in amyotrophic lateral sclerosis. J Neurol 2000;247:189-194.
    • (2000) J Neurol , vol.247 , pp. 189-194
    • de Carvalho, M.1    Miranda, P.C.2    Lourdes, S.L.M.3    Ducla-Soares, E.4
  • 10
    • 0030789324 scopus 로고    scopus 로고
    • Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis
    • Mills KR, Nithi KA. Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis. Muscle Nerve 1997;20:1137-1141.
    • (1997) Muscle Nerve , vol.20 , pp. 1137-1141
    • Mills, K.R.1    Nithi, K.A.2
  • 11
    • 67749084497 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-Evolutionary and other perspectives
    • Eisen A. Amyotrophic lateral sclerosis-Evolutionary and other perspectives. Muscle Nerve 2009;40:297-304.
    • (2009) Muscle Nerve , vol.40 , pp. 297-304
    • Eisen, A.1
  • 13
    • 84860377640 scopus 로고    scopus 로고
    • Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis?
    • Turner MR, Kiernan MC. Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis? Amyotroph Lateral Scler 2012;13:245-250.
    • (2012) Amyotroph Lateral Scler , vol.13 , pp. 245-250
    • Turner, M.R.1    Kiernan, M.C.2
  • 15
    • 0028037423 scopus 로고
    • Recurrent inhibition is decreased in patients with amyotrophic lateral sclerosis
    • Raynor EM, Shefner JM. Recurrent inhibition is decreased in patients with amyotrophic lateral sclerosis. Neurology 1994;44:2148-2153.
    • (1994) Neurology , vol.44 , pp. 2148-2153
    • Raynor, E.M.1    Shefner, J.M.2
  • 16
    • 4143058048 scopus 로고    scopus 로고
    • Cramps, muscle pain, and fasciculations: Not always benign?
    • de Carvalho M, Swash M. Cramps, muscle pain, and fasciculations: not always benign? Neurology 2004;63:721-723.
    • (2004) Neurology , vol.63 , pp. 721-723
    • de Carvalho, M.1    Swash, M.2
  • 17
    • 79960893429 scopus 로고    scopus 로고
    • Why is ALS so excited?
    • de Carvalho M. Why is ALS so excited? Clin Neurophysiol 2011;122: 1689-1690.
    • (2011) Clin Neurophysiol , vol.122 , pp. 1689-1690
    • de Carvalho, M.1
  • 18
    • 78650979326 scopus 로고    scopus 로고
    • Lower motor neuron involvement examined by quantitative electromyography in amyotrophic lateral sclerosis
    • Krarup C. Lower motor neuron involvement examined by quantitative electromyography in amyotrophic lateral sclerosis. Clin Neurophysiol 2011;122:414-422.
    • (2011) Clin Neurophysiol , vol.122 , pp. 414-422
    • Krarup, C.1
  • 19
    • 0034644207 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation and the human brain
    • Hallett M. Transcranial magnetic stimulation and the human brain. Nature 2000;406:147-150.
    • (2000) Nature , vol.406 , pp. 147-150
    • Hallett, M.1
  • 20
    • 34447262103 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation: A primer
    • Hallett M. Transcranial magnetic stimulation: a primer. Neuron 2007; 55:187-199.
    • (2007) Neuron , vol.55 , pp. 187-199
    • Hallett, M.1
  • 21
    • 0031914185 scopus 로고    scopus 로고
    • Threshold tracking techniques in the study of human peripheral nerve
    • Bostock H, Cikurel K, Burke D. Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 1998;21:137-158.
    • (1998) Muscle Nerve , vol.21 , pp. 137-158
    • Bostock, H.1    Cikurel, K.2    Burke, D.3
  • 22
    • 70349581626 scopus 로고    scopus 로고
    • ALS motor phenotype heterogeneity, focality, and spread: Deconstructing motor neuron degeneration
    • Ravits JM, La Spada AR. ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology 2009;73:805-811.
    • (2009) Neurology , vol.73 , pp. 805-811
    • Ravits, J.M.1    la Spada, A.R.2
  • 23
    • 0027296350 scopus 로고
    • Amyotrophic lateral sclerosis: Lower motor neuron disease spreading to upper motor neurons
    • Chou SM, Norris FH. Amyotrophic lateral sclerosis: lower motor neuron disease spreading to upper motor neurons. Muscle Nerve 1993; 16:864-869.
    • (1993) Muscle Nerve , vol.16 , pp. 864-869
    • Chou, S.M.1    Norris, F.H.2
  • 24
    • 0026565355 scopus 로고
    • Amyotrophic lateral sclerosis (ALS): A phylogenetic disease of the corticomotoneuron?
    • Eisen A, Kim S, Pant B. Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron? Muscle Nerve 1992;15: 219-224.
    • (1992) Muscle Nerve , vol.15 , pp. 219-224
    • Eisen, A.1    Kim, S.2    Pant, B.3
  • 25
    • 0035105962 scopus 로고    scopus 로고
    • Glutamate transporters in neurologic disease
    • Maragakis NJ, Rothstein JD. Glutamate transporters in neurologic disease. Arch Neurol 2001;58:365-370.
    • (2001) Arch Neurol , vol.58 , pp. 365-370
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 26
    • 0028322102 scopus 로고
    • Excitatory amino acids, free radicals and the pathogenesis of motor neuron disease
    • Zeman S, Lloyd C, Meldrum B, Leigh PN. Excitatory amino acids, free radicals and the pathogenesis of motor neuron disease. Neuropathol Appl Neurobiol 1994;20:219-231.
    • (1994) Neuropathol Appl Neurobiol , vol.20 , pp. 219-231
    • Zeman, S.1    Lloyd, C.2    Meldrum, B.3    Leigh, P.N.4
  • 27
    • 0029441620 scopus 로고
    • Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis
    • discussion 21-27
    • Rothstein JD. Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. Adv Neurol 1995;68:7-20; discussion 21-27.
    • (1995) Adv Neurol , vol.68 , pp. 7-20
    • Rothstein, J.D.1
  • 29
    • 0036787803 scopus 로고    scopus 로고
    • Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis
    • Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 2002;26:438-458.
    • (2002) Muscle Nerve , vol.26 , pp. 438-458
    • Heath, P.R.1    Shaw, P.J.2
  • 30
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990;11:379-387.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 31
    • 0029589516 scopus 로고
    • Ultrastructure of excitotoxic neuronal death in murine cortical culture
    • Regan RF, Panter SS, Witz A, Tilly JL, Giffard RG. Ultrastructure of excitotoxic neuronal death in murine cortical culture. Brain Res 1995; 705:188-198.
    • (1995) Brain Res , vol.705 , pp. 188-198
    • Regan, R.F.1    Panter, S.S.2    Witz, A.3    Tilly, J.L.4    Giffard, R.G.5
  • 32
    • 0029844831 scopus 로고    scopus 로고
    • The role of monoamine metabolism in oxidative glutamate toxicity
    • Maher P, Davis JB. The role of monoamine metabolism in oxidative glutamate toxicity. J Neurosci 1996;16:6394-6401.
    • (1996) J Neurosci , vol.16 , pp. 6394-6401
    • Maher, P.1    Davis, J.B.2
  • 33
    • 33947640544 scopus 로고    scopus 로고
    • On the relation of oxidative stress to neuroinflammation: Lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    • Hensley K, Mhatre M, Mou S, Pye QN, Stewart C, West M, et al. On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Antioxid Redox Signal 2006;8:2075-2087.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 2075-2087
    • Hensley, K.1    Mhatre, M.2    Mou, S.3    Pye, Q.N.4    Stewart, C.5    West, M.6
  • 34
    • 76049115176 scopus 로고    scopus 로고
    • Neocortical inhibitory system
    • Druga R. Neocortical inhibitory system. Folia Biol (Praha) 2009;55: 201-217.
    • (2009) Folia Biol (Praha) , vol.55 , pp. 201-217
    • Druga, R.1
  • 35
    • 18044382315 scopus 로고    scopus 로고
    • Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex
    • Ling LL, Hughes LF, Caspary DM. Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex. Neuroscience 2005;132:1103-1113.
    • (2005) Neuroscience , vol.132 , pp. 1103-1113
    • Ling, L.L.1    Hughes, L.F.2    Caspary, D.M.3
  • 36
    • 20144370710 scopus 로고    scopus 로고
    • Electrical synapses define networks of neocortical GABAergic neurons
    • Hestrin S, Galarreta M. Electrical synapses define networks of neocortical GABAergic neurons. Trends Neurosci 2005;28:304-309.
    • (2005) Trends Neurosci , vol.28 , pp. 304-309
    • Hestrin, S.1    Galarreta, M.2
  • 37
    • 0028817389 scopus 로고
    • Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum
    • Schwartz RD, Yu X, Katzman MR, Hayden-Hixson DM, Perry JM. Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum. J Neurosci 1995;15:529-539.
    • (1995) J Neurosci , vol.15 , pp. 529-539
    • Schwartz, R.D.1    Yu, X.2    Katzman, M.R.3    Hayden-Hixson, D.M.4    Perry, J.M.5
  • 39
    • 0027446580 scopus 로고
    • Cortical excitability in amyotrophic lateral sclerosis: A clue to pathogenesis
    • Eisen A, Pant B, Stewart H. Cortical excitability in amyotrophic lateral sclerosis: a clue to pathogenesis. Can J Neurol Sci 1993;20:11-16.
    • (1993) Can J Neurol Sci , vol.20 , pp. 11-16
    • Eisen, A.1    Pant, B.2    Stewart, H.3
  • 40
    • 0027213817 scopus 로고
    • Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients
    • Nihei K, McKee AC, Kowall NW. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol 1993;86:55-64.
    • (1993) Acta Neuropathol , vol.86 , pp. 55-64
    • Nihei, K.1    McKee, A.C.2    Kowall, N.W.3
  • 41
    • 0033765916 scopus 로고    scopus 로고
    • Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil
    • Lloyd CM, Richardson MP, Brooks DJ, Al-Chalabi A, Leigh PN. Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. Brain 2000;123:2289-2296.
    • (2000) Brain , vol.123 , pp. 2289-2296
    • Lloyd, C.M.1    Richardson, M.P.2    Brooks, D.J.3    Al-Chalabi, A.4    Leigh, P.N.5
  • 44
    • 84870063066 scopus 로고    scopus 로고
    • How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?
    • Baloh RH. How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other? Curr Opin Neurol 2012;25:701-707.
    • (2012) Curr Opin Neurol , vol.25 , pp. 701-707
    • Baloh, R.H.1
  • 45
    • 33749239968 scopus 로고    scopus 로고
    • Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease
    • Vucic S, Kiernan MC. Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. Brain 2006;129:2436-2446.
    • (2006) Brain , vol.129 , pp. 2436-2446
    • Vucic, S.1    Kiernan, M.C.2
  • 46
    • 78751607762 scopus 로고    scopus 로고
    • Does the motor cortex influence denervation in ALS? EMG studies of muscles with both contralateral and bilateral corticospinal innervation
    • de Carvalho M, Pinto S, Swash M. Does the motor cortex influence denervation in ALS? EMG studies of muscles with both contralateral and bilateral corticospinal innervation. Clin Neurophysiol 2011;122: 629-635.
    • (2011) Clin Neurophysiol , vol.122 , pp. 629-635
    • de Carvalho, M.1    Pinto, S.2    Swash, M.3
  • 47
    • 0023872487 scopus 로고
    • Preclinical and subclinical events in motor neuron disease
    • Swash M, Ingram D. Preclinical and subclinical events in motor neuron disease. J Neurol Neurosurg Psychiatry 1988;51:165-168.
    • (1988) J Neurol Neurosurg Psychiatry , vol.51 , pp. 165-168
    • Swash, M.1    Ingram, D.2
  • 49
    • 0031724091 scopus 로고    scopus 로고
    • Diagnosis of amyotrophic lateral sclerosis
    • Rowland LP. Diagnosis of amyotrophic lateral sclerosis. J Neurol Sci 1998;160 Suppl 1:S6-24.
    • (1998) J Neurol Sci , vol.160 , Issue.SUPPL. 1
    • Rowland, L.P.1
  • 50
    • 0031724092 scopus 로고    scopus 로고
    • Early diagnosis of ALS/MND
    • Swash M. Early diagnosis of ALS/MND. J Neurol Sci 1998;160 Suppl 1:S33-36.
    • (1998) J Neurol Sci , vol.160 , Issue.SUPPL. 1
    • Swash, M.1
  • 51
    • 44949243975 scopus 로고    scopus 로고
    • Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis
    • Vucic S, Nicholson GA, Kiernan MC. Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain 2008; 131:1540-1550.
    • (2008) Brain , vol.131 , pp. 1540-1550
    • Vucic, S.1    Nicholson, G.A.2    Kiernan, M.C.3
  • 52
    • 33645331591 scopus 로고    scopus 로고
    • Assessment of cortical excitability using threshold tracking techniques
    • Vucic S, Howells J, Trevillion L, Kiernan MC. Assessment of cortical excitability using threshold tracking techniques. Muscle Nerve 2006; 33:477-486.
    • (2006) Muscle Nerve , vol.33 , pp. 477-486
    • Vucic, S.1    Howells, J.2    Trevillion, L.3    Kiernan, M.C.4
  • 54
    • 0030695278 scopus 로고    scopus 로고
    • Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation
    • Ziemann U, Winter M, Reimers CD, Reimers K, Tergau F, Paulus W. Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation. Neurology 1997;49:1292-1298.
    • (1997) Neurology , vol.49 , pp. 1292-1298
    • Ziemann, U.1    Winter, M.2    Reimers, C.D.3    Reimers, K.4    Tergau, F.5    Paulus, W.6
  • 55
    • 0035074328 scopus 로고    scopus 로고
    • Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis
    • Stefan K, Kunesch E, Benecke R, Classen J. Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis. Ann Neurol 2001;49:536-539.
    • (2001) Ann Neurol , vol.49 , pp. 536-539
    • Stefan, K.1    Kunesch, E.2    Benecke, R.3    Classen, J.4
  • 56
    • 3242714976 scopus 로고    scopus 로고
    • TMS and drugs
    • Ziemann U. TMS and drugs. Clin Neurophysiol 2004;115:1717-1729.
    • (2004) Clin Neurophysiol , vol.115 , pp. 1717-1729
    • Ziemann, U.1
  • 58
    • 0034959263 scopus 로고    scopus 로고
    • Clinical electrophysiology of the upper and lower motor neuron in amyotrophic lateral sclerosis
    • Eisen A. Clinical electrophysiology of the upper and lower motor neuron in amyotrophic lateral sclerosis. Semin Neurol 2001;21:141-154.
    • (2001) Semin Neurol , vol.21 , pp. 141-154
    • Eisen, A.1
  • 59
    • 0032869111 scopus 로고    scopus 로고
    • Mechanism of the silent period following transcranial magnetic stimulation. Evidence from epidural recordings
    • Chen R, Lozano AM, Ashby P. Mechanism of the silent period following transcranial magnetic stimulation. Evidence from epidural recordings. Exp Brain Res 1999;128:539-542.
    • (1999) Exp Brain Res , vol.128 , pp. 539-542
    • Chen, R.1    Lozano, A.M.2    Ashby, P.3
  • 60
    • 0033152605 scopus 로고    scopus 로고
    • Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
    • Werhahn KJ, Kunesch E, Noachtar S, Benecke R, Classen J. Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans. J Physiol 1999;517:591-597.
    • (1999) J Physiol , vol.517 , pp. 591-597
    • Werhahn, K.J.1    Kunesch, E.2    Noachtar, S.3    Benecke, R.4    Classen, J.5
  • 61
  • 62
    • 0345270007 scopus 로고    scopus 로고
    • Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosis
    • Zanette G, Tamburin S, Manganotti P, Refatti N, Forgione A, Rizzuto N. Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosis. J Neurol 2002;249:1723-1728.
    • (2002) J Neurol , vol.249 , pp. 1723-1728
    • Zanette, G.1    Tamburin, S.2    Manganotti, P.3    Refatti, N.4    Forgione, A.5    Rizzuto, N.6
  • 63
    • 20444470252 scopus 로고    scopus 로고
    • Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: Studies with [11C]flumazenil PET
    • Turner MR, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, et al. Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET. Brain 2005;128: 1323-1329.
    • (2005) Brain , vol.128 , pp. 1323-1329
    • Turner, M.R.1    Hammers, A.2    Al-Chalabi, A.3    Shaw, C.E.4    Andersen, P.M.5    Brooks, D.J.6
  • 64
    • 41449091686 scopus 로고    scopus 로고
    • Cortical excitability testing distinguishes Kennedy's disease from amyotrophic lateral sclerosis
    • Vucic S, Kiernan MC. Cortical excitability testing distinguishes Kennedy's disease from amyotrophic lateral sclerosis. Clin Neurophysiol 2008;119:1088-1096.
    • (2008) Clin Neurophysiol , vol.119 , pp. 1088-1096
    • Vucic, S.1    Kiernan, M.C.2
  • 65
    • 34547620140 scopus 로고    scopus 로고
    • Abnormalities in cortical and peripheral excitability in flail arm variant amyotrophic lateral sclerosis
    • Vucic S, Kiernan MC. Abnormalities in cortical and peripheral excitability in flail arm variant amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2007;78:849-852.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 849-852
    • Vucic, S.1    Kiernan, M.C.2
  • 66
    • 0036848084 scopus 로고    scopus 로고
    • Different mechanisms contribute to motor cortex hyperexcitability in amyotrophic lateral sclerosis
    • Zanette G, Tamburin S, Manganotti P, Refatti N, Forgione A, Rizzuto N. Different mechanisms contribute to motor cortex hyperexcitability in amyotrophic lateral sclerosis. Clin Neurophysiol 2002;113:1688-1697.
    • (2002) Clin Neurophysiol , vol.113 , pp. 1688-1697
    • Zanette, G.1    Tamburin, S.2    Manganotti, P.3    Refatti, N.4    Forgione, A.5    Rizzuto, N.6
  • 67
    • 84861845989 scopus 로고    scopus 로고
    • Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis
    • Kanai K, Shibuya K, Sato Y, Misawa S, Nasu S, Sekiguchi Y, et al. Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2012; 83:734-738.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 734-738
    • Kanai, K.1    Shibuya, K.2    Sato, Y.3    Misawa, S.4    Nasu, S.5    Sekiguchi, Y.6
  • 68
    • 0031898458 scopus 로고    scopus 로고
    • Strength-duration properties of sensory and motor axons in amyotrophic lateral sclerosis
    • Mogyoros I, Kiernan MC, Burke D, Bostock H. Strength-duration properties of sensory and motor axons in amyotrophic lateral sclerosis. Brain 1998;121:851-859.
    • (1998) Brain , vol.121 , pp. 851-859
    • Mogyoros, I.1    Kiernan, M.C.2    Burke, D.3    Bostock, H.4
  • 69
    • 33645075174 scopus 로고    scopus 로고
    • Altered axonal excitability properties in amyotrophic lateral sclerosis: Impaired potassium channel function related to disease stage
    • Kanai K, Kuwabara S, Misawa S, Tamura N, Ogawara K, Nakata M, et al. Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage. Brain 2006;129:953-962.
    • (2006) Brain , vol.129 , pp. 953-962
    • Kanai, K.1    Kuwabara, S.2    Misawa, S.3    Tamura, N.4    Ogawara, K.5    Nakata, M.6
  • 70
    • 33745408196 scopus 로고    scopus 로고
    • Distal excitability changes in motor axons in amyotrophic lateral sclerosis
    • Nakata M, Kuwabara S, Kanai K, Misawa S, Tamura N, Sawai S, et al. Distal excitability changes in motor axons in amyotrophic lateral sclerosis. Clin Neurophysiol 2006;117:1444-1448.
    • (2006) Clin Neurophysiol , vol.117 , pp. 1444-1448
    • Nakata, M.1    Kuwabara, S.2    Kanai, K.3    Misawa, S.4    Tamura, N.5    Sawai, S.6
  • 71
    • 33745418427 scopus 로고    scopus 로고
    • Axonal excitability properties in amyotrophic lateral sclerosis
    • Vucic S, Kiernan MC. Axonal excitability properties in amyotrophic lateral sclerosis. Clin Neurophysiol 2006;117:1458-1466.
    • (2006) Clin Neurophysiol , vol.117 , pp. 1458-1466
    • Vucic, S.1    Kiernan, M.C.2
  • 72
    • 35748955508 scopus 로고    scopus 로고
    • Fatigue and activity dependent changes in axonal excitability in amyotrophic lateral sclerosis
    • Vucic S, Krishnan AV, Kiernan MC. Fatigue and activity dependent changes in axonal excitability in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2007;78:1202-1208.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 1202-1208
    • Vucic, S.1    Krishnan, A.V.2    Kiernan, M.C.3
  • 74
    • 0025925116 scopus 로고
    • Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter
    • Stys PK, Waxman SG, Ransom BR. Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Ann Neurol 1991;30:375-380.
    • (1991) Ann Neurol , vol.30 , pp. 375-380
    • Stys, P.K.1    Waxman, S.G.2    Ransom, B.R.3
  • 75
    • 58149527805 scopus 로고    scopus 로고
    • Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis
    • Pieri M, Carunchio I, Curcio L, Mercuri NB, Zona C. Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis. Exp Neurol 2009;215:368-379.
    • (2009) Exp Neurol , vol.215 , pp. 368-379
    • Pieri, M.1    Carunchio, I.2    Curcio, L.3    Mercuri, N.B.4    Zona, C.5
  • 76
    • 84857991252 scopus 로고    scopus 로고
    • The split hand syndrome in amyotrophic lateral sclerosis
    • Eisen A, Kuwabara S. The split hand syndrome in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2012;83:399-403.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 399-403
    • Eisen, A.1    Kuwabara, S.2
  • 77
    • 0033980961 scopus 로고    scopus 로고
    • The split hand syndrome
    • Wilbourn AJ. The split hand syndrome. Muscle Nerve 2000;23: 138.
    • (2000) Muscle Nerve , vol.23 , pp. 138
    • Wilbourn, A.J.1
  • 78
    • 41849108445 scopus 로고    scopus 로고
    • Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: Frequency, extent, and specificity
    • Kuwabara S, Sonoo M, Komori T, Shimizu T, Hirashima F, Inaba A, et al. Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity. Muscle Nerve 2008;37: 426-430.
    • (2008) Muscle Nerve , vol.37 , pp. 426-430
    • Kuwabara, S.1    Sonoo, M.2    Komori, T.3    Shimizu, T.4    Hirashima, F.5    Inaba, A.6
  • 79
    • 33750944733 scopus 로고    scopus 로고
    • Dissociated small hand muscle atrophy in aging: The 'senile hand' is a split hand
    • Voermans NC, Schelhaas HJ, Munneke M, Zwarts MJ. Dissociated small hand muscle atrophy in aging: the 'senile hand' is a split hand. Eur J Neurol 2006;13:1381-1384.
    • (2006) Eur J Neurol , vol.13 , pp. 1381-1384
    • Voermans, N.C.1    Schelhaas, H.J.2    Munneke, M.3    Zwarts, M.J.4
  • 80
    • 0032806964 scopus 로고    scopus 로고
    • Dissociated small hand muscle involvement in amyotrophic lateral sclerosis detected by motor unit number estimates
    • Kuwabara S, Mizobuchi K, Ogawara K, Hattori T. Dissociated small hand muscle involvement in amyotrophic lateral sclerosis detected by motor unit number estimates. Muscle Nerve 1999;22:870-873.
    • (1999) Muscle Nerve , vol.22 , pp. 870-873
    • Kuwabara, S.1    Mizobuchi, K.2    Ogawara, K.3    Hattori, T.4
  • 82
    • 84876067246 scopus 로고    scopus 로고
    • Split-hand plus sign in ALS: Differential involvement of the flexor pollicis longus and intrinsic hand muscles. Amyotroph Lateral Scler Frontotemporal Degener
    • Menon P, Bae JS, Mioshi E, Kiernan MC, Vucic S. Split-hand plus sign in ALS: Differential involvement of the flexor pollicis longus and intrinsic hand muscles. Amyotroph Lateral Scler Frontotemporal Degener. Forthcoming 2012.
    • (2012) Forthcoming
    • Menon, P.1    Bae, J.S.2    Mioshi, E.3    Kiernan, M.C.4    Vucic, S.5
  • 83
    • 33645739945 scopus 로고    scopus 로고
    • Frontotemporal lobar degeneration with motor neuron disease: A clinical and pathological spectrum
    • Clark CM, Forman MS. Frontotemporal lobar degeneration with motor neuron disease: a clinical and pathological spectrum. Arch Neurol 2006;63:489-490.
    • (2006) Arch Neurol , vol.63 , pp. 489-490
    • Clark, C.M.1    Forman, M.S.2
  • 84
    • 33749632259 scopus 로고    scopus 로고
    • Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006;314:130-133.
    • (2006) Science , vol.314 , pp. 130-133
    • Neumann, M.1    Sampathu, D.M.2    Kwong, L.K.3    Truax, A.C.4    Micsenyi, M.C.5    Chou, T.T.6
  • 85
    • 33750716074 scopus 로고    scopus 로고
    • TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006;351:602-611.
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 602-611
    • Arai, T.1    Hasegawa, M.2    Akiyama, H.3    Ikeda, K.4    Nonaka, T.5    Mori, H.6
  • 88
    • 41149180753 scopus 로고    scopus 로고
    • TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
    • Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 2008;319:1668-1672.
    • (2008) Science , vol.319 , pp. 1668-1672
    • Sreedharan, J.1    Blair, I.P.2    Tripathi, V.B.3    Hu, X.4    Vance, C.5    Rogelj, B.6
  • 89
    • 62149141328 scopus 로고    scopus 로고
    • Rethinking ALS: The FUS about TDP-43
    • Lagier-Tourenne C, Cleveland DW. Rethinking ALS: the FUS about TDP-43. Cell 2009;136:1001-1004.
    • (2009) Cell , vol.136 , pp. 1001-1004
    • Lagier-Tourenne, C.1    Cleveland, D.W.2
  • 90
    • 61349162349 scopus 로고    scopus 로고
    • Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis typ. 6
    • Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis typ. 6. Science 2009;323:1208-1211.
    • (2009) Science , vol.323 , pp. 1208-1211
    • Vance, C.1    Rogelj, B.2    Hortobágyi, T.3    de Vos, K.J.4    Nishimura, A.L.5    Sreedharan, J.6
  • 92
    • 80052924149 scopus 로고    scopus 로고
    • Motor neuron dysfunction in frontotemporal dementia
    • Burrell JR, Kiernan MC, Vucic S, Hodges JR. Motor neuron dysfunction in frontotemporal dementia. Brain 2011;134:2582-2594.
    • (2011) Brain , vol.134 , pp. 2582-2594
    • Burrell, J.R.1    Kiernan, M.C.2    Vucic, S.3    Hodges, J.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.