Mitochondrial abnormalities and synaptic loss underlie memory deficits seen in mouse models of obesity and Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 55, Issue 3, 2017, Pages 915-932

  Martins, Isaura V A ^a   Rivers Auty, Jack ^a   Allan, Stuart M ^a   Lawrence, Catherine B ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

3xTgAD; Alzheimer's disease; high fat diet; memory; mitochondria; Non Tg; obesity; synapses

Indexed keywords

FAT; INSULIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BODY FAT; BODY WEIGHT; BRAIN CAPILLARY ENDOTHELIUM; BRAIN CORTEX; BRAIN MITOCHONDRION; CELL COUNT; CELL DENSITY; CELL LOSS; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; INSULIN BLOOD LEVEL; LIPID DIET; MALE; MEMORY DISORDER; METABOLISM; MOUSE; NEUROPIL; NONHUMAN; OBESITY; PRIORITY JOURNAL; SYNAPSE; TIGHT JUNCTION; TRANSGENIC ANIMAL; TRANSMISSION ELECTRON MICROSCOPY; WORKING MEMORY; ANIMAL; BLOOD; BLOOD PRESSURE; C57BL MOUSE; COMPLICATION; DISEASE MODEL; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; MAZE TEST; MITOCHONDRION; ODOR; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RECOGNITION; TRANSGENIC MOUSE; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMALE; HIPPOCAMPUS; HUMANS; INSULIN; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; OBESITY; PRESENILIN-1; RECOGNITION (PSYCHOLOGY); SMELL; SYNAPSES; TAU PROTEINS;

EID: 85006013138     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160640     Document Type: Article

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