High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism

Brain, Behavior, and Immunity

Volumn 42, Issue , 2014, Pages 22-32

  Sobesky, Julia L ^a   Barrientos, Ruth M ^a   De May, Henning S ^a   Thompson, Brittany M ^a   Weber, Michael D ^a   Watkins, Linda R ^a   Maier, Steven F ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Dietary reversal; Fear conditioning; High fat diet; HIL 1RA; Hippocampus; Interleukin 1 ; Memory

Indexed keywords

INTERLEUKIN 1BETA; LEPTIN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOTSHOCK; HIPPOCAMPUS; INFLAMMATION; LIPID DIET; MALE; MEMORY; MEMORY DISORDER; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OBESITY; RAT; WEIGHT GAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CONDITIONING; DRUG EFFECTS; FEAR; MEMORY DISORDERS; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CONDITIONING (PSYCHOLOGY); DIET, HIGH-FAT; FEAR; HIPPOCAMPUS; INTERLEUKIN-1BETA; MALE; MEMORY; MEMORY DISORDERS; RATS; RATS, WISTAR; RECEPTORS, INTERLEUKIN-1;

EID: 84908622865     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.06.017     Document Type: Article

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