Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69, Issue 11, 2014, Pages 1339-1352

  Tucsek, Zsuzsanna ^a   Toth, Peter ^a   Tarantini, Stefano ^a   Sosnowska, Danuta ^a   Gautam, Tripti ^a   Warrington, Junie P ^a,b   Giles, Cory B ^c   Wren, Jonathan D ^c   Koller, Akos ^d   Ballabh, Praveen ^e   Sonntag, William E ^a   Ungvari, Zoltan ^a,d,f   Csiszar, Anna ^a,d,f  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d UNIVERSITY OF PÉCS   (Hungary)

^e WESTCHESTER MEDICAL CENTER   (United States)

^f UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Endothelial dysfunction; Learning and memory; MCI; Vascular cognitive impairment

Indexed keywords

MUS;

TRANSCRIPTOME;

ADVERSE EFFECTS; AGING; ANGIOGENESIS; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; COGNITION DISORDERS; COMPLICATION; DISEASE MODEL; GENETICS; HAND STRENGTH; HIPPOCAMPUS; LIPID DIET; MALE; MAZE TEST; MICROVASCULATURE; MOUSE; OBESITY; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PERICYTE; PHYSIOLOGY; PSYCHOLOGY; VASCULARIZATION;

AGING; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; HAND STRENGTH; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICROVESSELS; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY; OXIDATIVE STRESS; PERICYTES; TRANSCRIPTOME;

EID: 84911074681     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu080     Document Type: Article

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