Hypoxia-Up-Regulated Mitochondrial Movement Regulator Does Not Contribute to the APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease

Dementia and Geriatric Cognitive Disorders

Volumn 36, Issue 3-4, 2013, Pages 137-145

  Zou, Yan ^a   Li, Yu ^a   Yu, Weihua ^a   Du, Yingshi ^a   Shi, Rui ^a   Zhang, Man ^a   Duan, Jingxi ^a   Deng, Yongtao ^a   Tu, Qi ^a   Dai, Rong ^a   Lü, Yang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; APP PS1 double transgenic mouse; Hypoxia up regulated mitochondrial movement regulator; Mitochondria

Indexed keywords

AMYLOID PRECURSOR PROTEIN; HYPOXIA UP REGULATED MITOCHONDRIAL MOVEMENT REGULATOR; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PRESENILIN 1; PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL SWELLING; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; CEREBRAL CORTEX; EXONS; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MITOCHONDRIA; PRESENILIN-1; REAL-TIME POLYMERASE CHAIN REACTION; TRANSGENES;

EID: 84880649206     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000351669     Document Type: Article

References (32)

1. Reitz C, Brayne C, Mayeux R: Epidemiology of Alzheimer disease. Nat Rev Neurol 2011;7:137-152.
2. Swerdlow RH, Burns JM, Khan SM: The Alzheimer's disease mitochondrial cascade hypothesis. J Alzheimers Dis 2010;20(suppl 2):S265-S279.
3. Isobe C, Abe T, Terayama Y: Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients. Dement Geriatr Cogn Disord 2009;28:449-454.
4. Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X: Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem 2012;120:419-429.
5. Zhu X, Perry G, Smith MA, Wang X: Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 2013;33:S253-S262.
6. Kim J, Choi IY, Michaelis ML, Lee P: Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI. Neuroimage 2011;56:1286-1292.
7. Selfridge JE, E L, Lu J, Swerdlow RH: Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol Dis 2013;51:3-12.
8. Silva DFF, Esteves AR, Oliveira CR, Cardoso SM: Mitochondria: the common upstream driver of amyloid-β and tau pathology in Alzheimer's disease. Curr Alzheimer Res 2011;8:563-572.
9. Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, Haass C, Reichert AS, Müller WE: Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 2012;16:1421-1433.
10. Matsumoto T, Minegishi K, Ishimoto H, Tanaka M, Hennebold JD, Teranishi T, Hattori Y, Furuya M, Higuchi T, Asai S, Kim SH, Miyakoshi K, Yoshimura Y: Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis. Endocrinology 2009;150:3353-3359.
11. Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA: HUMMR, a hypoxia- and HIF-1α-inducible protein, alters mitochondrial distribution and transport. J Cell Biol 2009;185:1065-1081.
12. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW: Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation. J Biol Chem 2007;282:10873-10880.
13. Peers C, Dallas ML, Boycott HE, Scragg JL, Pearson HA, Boyle JP: Hypoxia and neurodegeneration. Ann NY Acad Sci 2009;1177:169-177.
14. Zhang X, Le W: Pathological role of hypoxia in Alzheimer's disease. Exp Neurol 2010;223:299-303.
15. Karbowski M, Neutzner A: Neurodegeneration as a consequence of failed mitochondrial maintenance. Acta Neuropathol 2012;123:157-171.
16. Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL: Retrograde axonal transport: pathways to cell death? Trends Neurosci 2010;33:335-344.
17. MacAskill AF, Kittler JT: Control of mitochondrial transport and localization in neurons. Trends Cell Biol 2010;20:102-112.
18. Moser MB, Moser EI: Functional differentiation in the hippocampus. Hippocampus 1998;8:608-619.
19. Leung KK, Bartlett JW, Barnes J, Manning EN, Ourselin S, Fox NC: Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration. Neurology 2013;80:648-654.
20. Jacobs HI, Van Boxtel MP, Jolles J, Verhey FR, Uylings HB: Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings. Neurosci Biobehav Rev 2012;36:297-309.
21. Lütjohann D, Heerschap A, Kiliaan AJ: DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis 2009;33:482-498.
22. Zerbi V, Jansen D, Dederen PJ, Veltien A, Hamans B, Liu Y, Heerschap A, Kiliaan AJ: Microvascular cerebral blood volume changes in aging APP(swe)/PS1(dE9) AD mouse model: a voxel-wise approach. Brain Struct Funct 2012, E-pub ahead of print.
23. Semenza GL: Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 2009;24:97-106.
24. Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC: Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci 2007;27:6320-6332.
25. Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, Siddiqui A, Tamura Y, Sesaki H, Wengenack TM, Dzeja PP, Poduslo JF: Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS One 2012;7:e32737.
26. Hauptmann S, Scherping I, Dröse S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, Müller WE: Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 2009;30:1574-1586.
27. Saxton WM, Hollenbeck PJ: The axonal transport of mitochondria. J Cell Sci 2012;125:2095-2104.
28. Morel M, Héraud C, Nicaise C, Suain V, Brion JP: Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport. Acta Neuropathol 2012;123:71-84.
29. Sompol P, Ittarat W, Tangpong J, Chen Y, Doubinskaia I, Batinic-Haberle I, Abdul HM, Butterfield DA, St Clair DK: A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. Neuroscience 2008;153:120-130.
30. Morán M, Moreno-Lastres D, Marín-Buera L, Arenas J, Martín MA, Ugalde C: Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration. Free Radic Biol Med 2012;53:595-609.
31. Viswanathan A, Rocca WA, Tzourio C: Vascular risk factors and dementia: how to move forward? Neurology 2009;72:368-374.
32. Li L, Zhang X, Yang D, Luo G, Chen S, Le W: Hypoxia increases A-beta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging 2009;30:1091-1098.