Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study

British Medical Journal

Volumn 330, Issue 7504, 2005, Pages 1360-1362

  Whitmer, Rachel A ^a   Gunderson, Erica P ^a   Barrett Connor, Elizabeth ^b   Quesenberry Jr , Charles P ^a   Yaffe, Kristine ^c  

^a DIVISION OF RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACADEMIC ACHIEVEMENT; ADULT; AGE DISTRIBUTION; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; COMORBIDITY; DEMENTIA; DIABETES MELLITUS; ETHNOLOGY; FEMALE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MARRIAGE; OBESITY; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SEX RATIO; SKINFOLD THICKNESS; STATISTICAL ANALYSIS; STROKE; UNITED STATES; AGED; COHORT ANALYSIS; COMPARATIVE STUDY; MIDDLE AGED; PSYCHOLOGICAL ASPECT;

AGED; AGED, 80 AND OVER; BODY MASS INDEX; COHORT STUDIES; DEMENTIA; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; PROSPECTIVE STUDIES; RISK FACTORS; SKINFOLD THICKNESS;

EID: 20544462061     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.38446.466238.E0     Document Type: Article

References (16)

1. Brookmeyer R, Gray S. Methods for projecting the incidence and prevalence of chronic diseases in aging populations: application to Alzheimer's disease. Stat Med 2000;19:1481-93.
2. Wang SY. Weight loss and metabolic changes in dementia. J Nutr Health Aging 2002;6:201-5.
3. Gustafson D, Rothenberg E, Blennow K, Steen B, Skoog I. An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med 2003;163:1524-8.
4. Baumgartner RN, Heymsfield SB, Roche AF. Human body composition and the epidemiology of chronic disease. Obes Res 1995;3:73-95.
5. Cronin-Stubbs D, Beckett LA, Scherr FA, Field TS, Chown MJ, Pilgrim DM, et al. Weight loss in people with Alzheimer's disease: a prospective population based analysis. BMJ 1997;314:178-9.
6. Knittweis J. Weight loss precedes Alzheimer's disease symptoms: a case study. J Am Geriatr Soc 1998;46:540-1.
7. Barrett-Connor E, Edelstein S, Corey-Bloom J, Wiederholt W. Weight loss precedes dementia in community-dwelling older adults. J Nutr Health Aging 1998;2:113-4.
8. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 2004;292:2237-42.
9. Funahashi H, Yada T, Suzuki R, Shioda S. Distribution, function, and properties of leptin receptors in the brain. Int Rev Cytol 2003;224:1-27.
10. Harvey J. Novel actions of leptin in the hippocampus. Ann Med 2003;35:197-206.
11. Das UN. Is obesity an inflammatory condition? Nutrition 2001;17:953-66.
12. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia aging study. Ann Neurol 2002;52:168-74.
13. Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 2003;61:76-80.
14. Gustafson D, Lissner L, Bengtsson C, Bjorkelund C, Skoog I. A 24-year follow-up of body mass index and cerebral atrophy. Neurology 2004;63:1876-81.
15. Gustafson DR, Steen B, Skoog I. Body mass index and white matter lesions in elderly women. An 18-year longitudinal study. Int Psychogeriatr 2004;16:327-36.
16. Abbott RD, Ross GW, White LR, Nelson JS, Masaki KH, Tanner CM, et al. Midlife adiposity and the future risk of Parkinson's disease. Neurology 2002;59:1051-7.