Insulin, cognition, and dementia

European Journal of Pharmacology

Volumn 719, Issue 1-3, 2013, Pages 170-179

  Cholerton, Brenna ^a,b   Baker, Laura D ^c   Craft, Suzanne ^c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Alzheimer's disease; Cognition; Diabetes; Insulin

Indexed keywords

AMYLOID BETA PROTEIN; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE;

ALZHEIMER DISEASE; COGNITION; COGNITIVE DEFECT; DEMENTIA; DIABETES MELLITUS; DISEASE ASSOCIATION; DYSLIPIDEMIA; EPIDEMIC; HUMAN; HYPERTENSION; INSULIN RESISTANCE; NEUROPROTECTION; NONHUMAN; OBESITY; PREVALENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; RISK; VASCULAR DISEASE;

AGING; ALZHEIMER'S DISEASE; COGNITION; DIABETES; INSULIN;

ALZHEIMER DISEASE; ANIMALS; BRAIN; COGNITION; DEMENTIA; HUMANS; INSULIN; INSULIN RESISTANCE;

EID: 84888289180     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.008     Document Type: Review

References (143)

1. M.A. Abbott, D.G. Wells, and J.R. Fallon The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS syna (Pubitemid 29404586)
2. K.J. Anstey, D.M. Lipnicki, and L.F. Low Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis American Journal of Geriatric Psychiatry 16 2008 343 354
3. J. Apelt, G. Mehlhorn, and R. Schliebs Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain Journal of Neuroscience Research 57 1999 693 705 (Pubitemid 29411483)
4. Z. Arvanitakis, R.S. Wilson, J.L. Bienias, D.A. Evans, and D.A. Bennett Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function Archives of Neurology 61 2004 661 666 (Pubitemid 38637681)
5. F. Authier, B.I. Posner, and J.J. Bergeron Insulin-degrading enzyme Clinical & Investigative Medicine 19 1996 149 160 (Pubitemid 26225900)
6. K.V. Axen, A. Dikeakos, and A. Sclafani High dietary fat promotes syndrome X in nonobese rats Journal of Nutrition 133 2003 2244 2249 (Pubitemid 36841548)
7. Z. Bagi, A. Koller, and G. Kaley PPAR{gamma} activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes American Journal of Physiology-Heart and Circulatory Physiology 286 2004 H742 H748
8. H. Baker, and R.F. Spencer Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat Experimental Brain Research 63 1986 461 473 (Pubitemid 16036221)
9. L.D. Baker, D.J. Cross, S. Minoshima, D. Belongia, G.S. Watson, and S. Craft Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes Archives of Neurology 68 2011 51 57
10. B.J. Balin, R.D. Broadwell, M. Salcman, and M. el-Kalliny Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey Journal of Comparative Neurology 251 1986 260 280 (Pubitemid 16027854)
11. W.A. Banks, J.B. Jaspan, W. Huang, and A.J. Kastin Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin Peptides 18 1997 1423 1429 (Pubitemid 27519755)
12. W.A. Banks, J.B. Jaspan, and A.J. Kastin Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays Peptides 18 1997 1257 1262 (Pubitemid 28026898)
13. D.G. Baskin, D.P. Figlewicz, S.C. Woods, D. Porte Jr., and D.M. Dorsa Insulin in the brain Annual Review of Physiology 49 1987 335 347 (Pubitemid 17053899)
14. G.D. Baura, D.M. Foster, D. Porte Jr., S.E. Kahn, R.N. Bergman, C. Cobelli, and M.W. Schwartz Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain Journal of Clinical Investigation 92 1993 1824 1830 (Pubitemid 23304549)
15. M.S. Beeri, J. Schmeidler, J.M. Silverman, S. Gandy, M. Wysocki, C.M. Hannigan, D.P. Purohit, G. Lesser, H.T. Grossman, and V. Haroutunian Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology Neurology 71 2008 750 757
16. C. Benedict, M. Hallschmid, A. Hatke, B. Schultes, H.L. Fehm, J. Born, and W. Kern Intranasal insulin improves memory in humans Psychoneuroendocrinology 29 2004 1326 1334 (Pubitemid 39024358)
17. C. Benedict, W. Kern, B. Schultes, J. Born, and M. Hallschmid Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin The Journal of Clinical Endocrinology and Metabolism 93 2008 1339 1344 (Pubitemid 351519730)
18. E.M. Bingham, D. Hopkins, D. Smith, A. Pernet, W. Hallett, L. Reed, P.K. Marsden, and S.A. Amiel The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study Diabetes 51 2002 3384 3390 (Pubitemid 35403440)
19. J. Born, T. Lange, W. Kern, G.P. McGregor, U. Bickel, and H.L. Fehm Sniffing neuropeptides: a transnasal approach to the human brain Nature Neuroscience 5 2002 514 516 (Pubitemid 34568991)
20. D.M. Bravata, C.K. Wells, J. Concato, W.N. Kernan, L.M. Brass, and B.I. Gulanski Two measures of insulin sensitivity provided similar information in a U.S. population Journal of Clinical Epidemiology 57 2004 1214 1217 (Pubitemid 39573031)
21. G.A. Bray, J.C. Lovejoy, S.R. Smith, J.P. DeLany, M. Lefevre, D. Hwang, D.H. Ryan, and D.A. York The influence of different fats and fatty acids on obesity, insulin resistance and inflammation Journal of Nutritional 132 2002 2488 2491 (Pubitemid 35013224)
22. R.D. Broadwell, and B.J. Balin Endocytic and exocytic pathways of the neuronal secretory process and trans-synaptic transfer of wheat germ agglutinin-horseradish peroxidase in vivo Journal of Comparative Neurology 242 1985 632 650 (Pubitemid 16176081)
23. B.L. Burgess, S.A. McIsaac, K.E. Naus, J.Y. Chan, G.H. Tansley, J. Yang, F. Miao, C.J. Ross, M. van Eck, M.R. Hayden, W. van Nostrand, P. St George-Hyslop, D. Westaway, and C.L. Wellington Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma Neurobiology of Disease 24 2006 114 127 (Pubitemid 44416212)
24. D. Cao, H. Lu, T.L. Lewis, and L. Li Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease Journal of Biological Chemistry 282 2007 36275 36282
25. A. Cedazo-Minguez, M.A. Ismail, and L. Mateos Plasma cholesterol and risk for late-onset Alzheimer's disease Expert Review of Neurotherapeutics 11 2011 495 498
26. E. Cersosimo, and R.A. DeFronzo Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases Diabetes/Metabolism Research and Reviews 22 2006 423 436 (Pubitemid 44774046)
27. C.K. Combs, D.E. Johnson, J.C. Karlo, S.B. Cannady, and G.E. Landreth Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists Journal of Neuroscience 20 2000 558 567 (Pubitemid 30225558)
28. D.G. Cook, J.B. Leverenz, P.J. McMillan, J.J. Kulstad, S. Ericksen, R.A. Roth, G.D. Schellenberg, L.W. Jin, K.S. Kovacina, and S. Craft Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele American Journal of Pathology 162 2003 313 319 (Pubitemid 36042013)
29. M.A. Cornier, D. Dabelea, T.L. Hernandez, R.C. Lindstrom, A.J. Steig, N.R. Stob, R.E. Van Pelt, H. Wang, and R.H. Eckel The metabolic syndrome Endocrine Reviews 29 2008 777 822
30. J.C. Corton, S.P. Anderson, and A. Stauber Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators Annual Review of Pharmacology and Toxicology 40 2000 491 518 (Pubitemid 30340691)
31. S. Craft, S. Asthana, D.G. Cook, L.D. Baker, M. Cherrier, K. Purganan, C. Wait, A. Petrova, S. Latendresse, G.S. Watson, J.W. Newcomer, G.D. Schellenberg, and A.J. Krohn Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype Psychoneuroendocrinology 28 2003 809 822 (Pubitemid 36695035)
32. S. Craft, S. Asthana, J.W. Newcomer, C.W. Wilkinson, I.T. Matos, L.D. Baker, M. Cherrier, C. Lofgreen, S. Latendresse, A. Petrova, S. Plymate, M. Raskind, K. Grimwood, and R.C. Veith Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose Archives of General Psychiatry 56 1999 1135 1140
33. S. Craft, L.D. Baker, T.J. Montine, S. Minoshima, G.S. Watson, A. Claxton, M. Arbuckle, M. Callaghan, E. Tsai, S.R. Plymate, P.S. Green, J. Leverenz, D. Cross, and B. Gerton Intranasal insulin therapy for alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial Archives of Neurology 2011
34. S. Craft, J. Newcomer, S. Kanne, S. Dagogo-Jack, P. Cryer, Y. Sheline, J. Luby, A. Dagogo-Jack, and A. Alderson Memory improvement following induced hyperinsulinemia in Alzheimer's disease Neurobiology of Aging 17 1996 123 130 (Pubitemid 26019103)
35. S. Craft, E. Peskind, M.W. Schwartz, G.D. Schellenberg, M. Raskind, and D. Porte Jr. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype Neurology 50 1998 164 168
36. S. Craft, and G.S. Watson Insulin and neurodegenerative disease: shared and specific mechanisms Lancet Neurology 3 2004 169 178 (Pubitemid 38229951)
37. S. Cuzzocrea, B. Pisano, L. Dugo, A. Ianaro, P. Maffia, N.S. Patel, R. Di Paola, A. Ialenti, T. Genovese, P.K. Chatterjee, M. Di Rosa, A.P. Caputi, and C. Thiemermann Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation European Journal of Pharmacology 483 2004 79 93 (Pubitemid 38056607)
38. F.G. De Felice, M.N. Vieira, T.R. Bomfim, H. Decker, P.T. Velasco, M.P. Lambert, K.L. Viola, W.Q. Zhao, S.T. Ferreira, and W.L. Klein Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers Proceedings of the National Academy of Sciences of the United States of America 106 2009 1971 1976
39. S.M. de la Monte, and J.R. Wands Alzheimer's disease is type 3 diabetes-evidence reviewed Journal of Diabetes Science and Technology 2 2008 1101 1113
40. P. Delerive, J.C. Fruchart, and B. Staels Peroxisome proliferator- activated receptors in inflammation control Journal of Endocrinology 169 2001 453 459 (Pubitemid 32536978)
41. P. Escher, and W. Wahli Peroxisome proliferator-activated receptors: insight into multiple cellular functions Mutation Research 448 2000 121 138 (Pubitemid 30139449)
42. W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, M.P. Frosch, C.B. Eckman, R.E. Tanzi, D.J. Selkoe, and S. Guenette Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo Proceedings of the National Academy of Sciences of the United States of America 100 2003 4162 4167 (Pubitemid 36418174)
43. D.P. Figlewicz, P. Szot, P.A. Israel, C. Payne, and D.M. Dorsa Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus Brain Research 602 1993 161 164 (Pubitemid 23045607)
44. G.J. Francis, J.A. Martinez, W.Q. Liu, K. Xu, A. Ayer, J. Fine, U.I. Tuor, G. Glazner, L.R. Hanson, W.H. Frey 2nd, and C. Toth Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy Brain 131 2008 3311 3334
45. W.H. Frey 2nd Intranasal delivery: bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord Drug Development & Delivery 2 2002 46 49
46. L. Frolich, D. Blum-Degen, H.G. Bernstein, S. Engelsberger, J. Humrich, S. Laufer, D. Muschner, A. Thalheimer, A. Turk, S. Hoyer, R. Zochling, K.W. Boissl, K. Jellinger, and P. Riederer Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease Journal of Neural Transmission 105 1998 423 438 (Pubitemid 28365027)
47. L. Gasparini, G.K. Gouras, R. Wang, R.S. Gross, M.F. Beal, P. Greengard, and H. Xu Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 21 2001 2561 2570 (Pubitemid 32298198)
48. D.S. Geldmacher, T. Fritsch, M.J. McClendon, and G. Landreth A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease Archives of Neurology 68 2011 45 50
49. K. Gerozissis, M. Orosco, C. Rouch, and S. Nicolaidis Basal and hyperinsulinemia-induced immunoreactive hypothalamic insulin changes in lean and genetically obese Zucker rats revealed by microdialysis Brain Research 611 1993 258 263 (Pubitemid 23159693)
50. M. Gold, C. Alderton, M. Zvartau-Hind, S. Egginton, A.M. Saunders, M. Irizarry, S. Craft, G. Landreth, U. Linnamagi, and S. Sawchak Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study Dementia and Geriatric Cognitive Disorders 30 2010 131 146
51. M. Hallschmid, C. Benedict, B. Schultes, J. Born, and W. Kern Obese men respond to cognitive but not to catabolic brain insulin signaling International Journal of Obesity 32 2008 275 282 (Pubitemid 351271786)
52. H. Hanyu, T. Sato, A. Kiuchi, H. Sakurai, and T. Iwamoto Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus Journal of the American Geriatrics Society 57 2009 177 179
53. H. Hanyu, T. Sato, H. Sakurai, and T. Iwamoto The role of tumor necrosis factor-alpha in cognitive improvement after peroxisome proliferator-activator receptor gamma agonist pioglitazone treatment in Alzheimer's disease Journal of the American Geriatrics Society 58 2010 1000 1001
54. C. Harrington, S. Sawchak, C. Chiang, J. Davies, C. Donovan, A.M. Saunders, M. Irizarry, B. Jeter, M. Zvartau-Hind, C.H. van Dyck, and M. Gold Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies Current Alzheimer Research 8 2011 592 606
55. J. Havrankova, J. Roth, and M. Brownstein Insulin receptors are widely distributed in the central nervous system of the rat Nature 272 1978 827 829 (Pubitemid 8316991)
56. J. Havrankova, D. Schmechel, J. Roth, and M. Brownstein Identification of insulin in rat brain Proceedings of the National Academy of Sciences of the United States of America 75 1978 5737 5741 (Pubitemid 9101469)
57. R. Hernandez, T. Teruel, C. De Alvaro, and M. Lorenzo Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases Diabetologia 2004
58. E.C. Hirsch, T. Breidert, E. Rousselet, S. Hunot, A. Hartmann, and P.P. Michel The role of glial reaction and inflammation in Parkinson's disease Annals of the New York Academy of Sciences 991 2003 214 228 (Pubitemid 36793816)
59. L. Ho, W. Qin, P.N. Pompl, Z. Xiang, J. Wang, Z. Zhao, Y. Peng, G. Cambareri, A. Rocher, C.V. Mobbs, P.R. Hof, and G.M. Pasinetti Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease FASEB Journal 18 2004 902 904
60. M. Hong, and V. Lee Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons Journal of Biological Chemistry 272 1997 19547 19553 (Pubitemid 27337756)
61. S. Hoyer The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review Journal of Neural Transmission 109 2002 991 1002 (Pubitemid 34762337)
62. C. Iadecola, and R.L. Davisson Hypertension and cerebrovascular dysfunction Cell Metabolism 7 2008 476 484 (Pubitemid 351729202)
63. L. Illum Nasal drug delivery: new developments and strategies Drug Discovery Today 7 2002 1184 1189 (Pubitemid 35430155)
64. J. Janson, T. Laedtke, J.E. Parisi, P. O'Brien, R.C. Petersen, and P.C. Butler Increased risk of type 2 diabetes in Alzheimer disease Diabetes 53 2004 474 481 (Pubitemid 38174565)
65. K.J. Kaiyala, R.L. Prigeon, S.E. Kahn, S.C. Woods, and M.W. Schwartz Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs Diabetes 49 2000 1525 1533
66. A. Kamagate, S. Qu, G. Perdomo, D. Su, D.H. Kim, S. Slusher, M. Meseck, and H.H. Dong FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice Journal of Clinical Investigation 118 2008 2347 2364 (Pubitemid 351872351)
67. H. Kenna, F. Hoeft, R. Kelley, T. Wroolie, B. DeMuth, A. Reiss, and N. Rasgon Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease Neurobiology of Aging 34 2013 641 649
68. S.P. Kennelly, B.A. Lawlor, and R.A. Kenny Blood pressure and the risk for dementia: a double edged sword Ageing Research Reviews 8 2009 61 70
69. W. Kern, J. Born, H. Schreiber, and H.L. Fehm Central nervous system effects of intranasally administered insulin during euglycemia in men Diabetes 48 1999 557 563 (Pubitemid 29106869)
70. W. Kern, A. Peters, B. Fruehwald-Schultes, E. Deininger, J. Born, and H.L. Fehm Improving influence of insulin on cognitive functions in humans Neuroendocrinology 74 2001 270 280 (Pubitemid 34701752)
71. M. Kivipelto, E.L. Helkala, M.P. Laakso, T. Hanninen, M. Hallikainen, K. Alhainen, H. Soininen, J. Tuomilehto, and A. Nissinen Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study British Medical Journal 322 2001 1447 1451 (Pubitemid 32575406)
72. M. Kivipelto, T. Ngandu, L. Fratiglioni, M. Viitanen, I. Kareholt, B. Winblad, E.L. Helkala, J. Tuomilehto, H. Soininen, and A. Nissinen Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease Archives of Neurology 62 2005 1556 1560 (Pubitemid 41434560)
73. S.R. Kopf, and C.M. Baratti Effects of posttraining administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism Neurobiology of Learning and Memory 71 1999 50 61 (Pubitemid 29393791)
74. I.V. Kurochkin, and S. Goto Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme FEBS Letters 345 1994 33 37
75. G. Landreth Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease Current Alzheimer Research 4 2007 159 164 (Pubitemid 46557505)
76. L.J. Launer, G.W. Ross, H. Petrovitch, K. Masaki, D. Foley, L.R. White, and R.J. Havlik Midlife blood pressure and dementia: the Honolulu-Asia aging study Neurobiology of Aging 21 2000 49 55 (Pubitemid 30224785)
77. C.C. Lee, Y.M. Kuo, C.C. Huang, and K.S. Hsu Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation Neurobiology of Aging 30 2009 377 387
78. C.L. Leibson, W.A. Rocca, V.A. Hanson, R. Cha, E. Kokmen, P.C. O'Brien, and P.J. Palumbo The risk of dementia among persons with diabetes mellitus: a population-based cohort study Annals of the New York Academy of Sciences 826 1997 422 427 (Pubitemid 27478066)
79. N.K. Lima, F. Abbasi, C. Lamendola, and G.M. Reaven Prevalence of insulin resistance and related risk factors for cardiovascular disease in patients with essential hypertension American Journal of Hypertension 22 2009 106 111
80. S.B.B. López, Y.M. Pacheco, J. Villar, R. Abia, and F.J. Muriana Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids American Journal of Clinical Nutrition 88 2008 638 644
81. J.A. Luchsinger Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective European Journal of Pharmacology 585 2008 119 129
82. J.A. Luchsinger, B. Patel, M.X. Tang, N. Schupf, and R. Mayeux Body mass index, dementia, and mortality in the elderly Journal of Nutrition Health and Aging 12 2008 127 131 (Pubitemid 351219629)
83. D. Luo, X. Hou, L. Hou, M. Wang, S. Xu, C. Dong, and X. Liu Effect of pioglitazone on altered expression of Abeta metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance European Journal of Pharmacology 664 2011 14 19
84. P.A. Maher, and D.R. Schubert Metabolic links between diabetes and Alzheimer's disease Expert Review of Neurotherapeutics 9 2009 617 630
85. J.C. Mamo, L. Jian, A.P. James, L. Flicker, H. Esselmann, and J. Wiltfang Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment Annals of Clinical Biochemistry 45 2008 395 403 (Pubitemid 352031547)
86. E. Mannucci, M. Monami, M. Di Bari, C. Lamanna, F. Gori, G.F. Gensini, and N. Marchionni Cardiac safety profile of rosiglitazone: a comprehensive meta-analysis of randomized clinical trials International Journal of Cardiology 143 2010 135 140
87. J.R. McDermott, and A.M. Gibson Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme Neurochemical Research 22 1997 49 56
88. P. Mohanty, A. Aljada, H. Ghanim, D. Hofmeyer, D. Tripathy, T. Syed, W. Al-Haddad, S. Dhindsa, and P. Dandona Evidence for a potent antiinflammatory effect of rosiglitazone Journal of Clinical Endocrinology & Metabolism 89 2004 2728 2735
89. J.H. Moon, H.J. Kim, A.H. Yang, H.M. Kim, B.W. Lee, E.S. Kang, H.C. Lee, and B.S. Cha The effect of rosiglitazone on LRP1 expression and amyloid beta uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment International Journal of Neuropsychopharmacology 2011 1 8
90. T. Ninomiya, T. Ohara, Y. Hirakawa, D. Yoshida, Y. Doi, J. Hata, S. Kanba, T. Iwaki, and Y. Kiyohara Midlife and late-life blood pressure and dementia in Japanese elderly: the hisayama study Hypertension 58 2011 22 28
91. J.M. Olefsky Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists Journal of Clinical Investigation 106 2000 467 472 (Pubitemid 30666379)
92. A. Ott, R.P. Stolk, A. Hofman, F. van Harskamp, D.E. Grobbee, and M.M. Breteler Association of diabetes mellitus and dementia: the Rotterdam study Diabetologia 39 1996 1392 1397 (Pubitemid 26356072)
93. A. Ott, R.P. Stolk, F. van Harskamp, H.A. Pols, A. Hofman, and M.M. Breteler Diabetes mellitus and the risk of dementia: the Rotterdam study Neurology 53 1999 1937 1942
94. J.H. Paik, J.H. Ju, J.Y. Lee, M.D. Boudreau, and D.H. Hwang Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways Journal of Biological Chemistry 275 2000 28173 28179
95. G. Pandini, V. Pace, A. Copani, S. Squatrito, D. Milardi, and R. Vigneri Insulin has multiple antiamyloidogenic effects on human neuronal cells Endocrinology 154 2013 375 387
96. C.R. Park, R.J. Seeley, S. Craft, and S.C. Woods Intracerebroventricular insulin enhances memory in a passive-avoidance task Physiology and Behavior 68 2000 509 514 (Pubitemid 30129236)
97. E.J. Park, S.Y. Park, E.H. Joe, and I. Jou 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia Journal of Biological Chemistry 278 2003 14747 14752 (Pubitemid 36799798)
98. A.R. Pathan, B. Viswanad, S.K. Sonkusare, and P. Ramarao Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats Life Sciences 79 2006 2209 2216 (Pubitemid 44646475)
99. A. Perez, L. Morelli, J.C. Cresto, and E.M. Castano Degradation of soluble amyloid B-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains Neurochemical Research 25 2000 247 255 (Pubitemid 30210091)
100. H. Petrovitch, L.R. White, G. Izmirilian, G.W. Ross, R.J. Havlik, W. Markesbery, J. Nelson, D.G. Davis, J. Hardman, D.J. Foley, and L.J. Launer Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging study Neurobiology of Aging 21 2000 57 62 (Pubitemid 30224786)
101. L.S. Piers, K.Z. Walker, R.M. Stoney, M.J. Soares, and K. O'Dea The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream) International Journal of Obesity and Related Metabolic Disorders 26 2002 814 821 (Pubitemid 34620874)
102. G.G. Piroli, C.A. Grillo, L.R. Reznikov, S. Adams, B.S. McEwen, M.J. Charron, and L.P. Reagan Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus Neuroendocrinology 85 2007 71 80 (Pubitemid 46725693)
103. J. Proietto, A. Filippis, C. Nakhla, and S. Clark Nutrient-induced insulin resistance Molecular and Cellular Endocrinology 151 1999 143 149
104. W. Qiu, D. Walsh, Z. Ye, K. Vekrellis, J. Zhang, M. Podlisny, M. Rosner, A. Safavi, L. Hersh, and D. Selkoe Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation Journal of Biological Chemistry 273 1998 32730 32738 (Pubitemid 28557658)
105. L.P. Reagan, N. Gorovits, E.K. Hoskin, S.E. Alves, E.B. Katz, C.A. Grillo, G.G. Piroli, B.S. McEwen, and M.J. Charron Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats Proceedings of the National Academy of Sciences of the United States of America 98 2001 2820 2825 (Pubitemid 32209567)
106. G.M. Reaven Insulin resistance in noninsulin-dependent diabetes mellitus. Does it exist and can it be measured? American Journal of Medicine 74 1983 3 17
107. G.M. Reaven The insulin resistance syndrome Current Atherosclerosis Reports 5 2003 364 371 (Pubitemid 38898895)
108. M.A. Reger, G.S. Watson, W.H. Frey 2nd, L.D. Baker, B. Cholerton, M.L. Keeling, D.A. Belongia, M.A. Fishel, S.R. Plymate, G.D. Schellenberg, M.M. Cherrier, and S. Craft Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype Neurobiology of Aging 27 2006 451 458 (Pubitemid 43185331)
109. M.A. Reger, G.S. Watson, P.S. Green, L.D. Baker, B. Cholerton, M.A. Fishel, S.R. Plymate, M.M. Cherrier, G.D. Schellenberg, W.H. Frey 2nd, and S. Craft Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults Journal of Alzheimer's Disease JAD 13 2008 323 331 (Pubitemid 352039034)
110. M.A. Reger, G.S. Watson, P.S. Green, C.W. Wilkinson, L.D. Baker, B. Cholerton, M.A. Fishel, S.R. Plymate, J.C.S. Breitner, W. DeGroodt, P. Mehta, and S. Craft Intranasal insulin improves cognition and modulates beta-amyloid in early AD Neurology 70 2008 440 448
111. C. Reitz, J. Luchsinger, M.X. Tang, J. Manly, and R. Mayeux Impact of plasma lipids and time on memory performance in healthy elderly without dementia Neurology 64 2005 1378 1383 (Pubitemid 40570505)
112. M.E. Risner, A.M. Saunders, J.F. Altman, G.C. Ormandy, S. Craft, I.M. Foley, M.E. Zvartau-Hind, D.A. Hosford, and A.D. Roses Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease Pharmacogenomics Journal 6 2006 246 254 (Pubitemid 44137951)
113. E. Rivera, A. Goldin, N. Fulmer, R. Tavares, J. Wands, and S. de la Monte Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine Journal of Alzheimer's Disease 8 2005 247 268
114. T. Sato, H. Hanyu, K. Hirao, H. Kanetaka, H. Sakurai, and T. Iwamoto Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease Neurobiology of Aging 32 2011 1626 1633
115. F. Schinzari, M. Tesauro, V. Rovella, A. Galli, N. Mores, O. Porzio, D. Lauro, and C. Cardillo Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with obesity-related metabolic syndrome American Journal of Physiology - Endocrinology and Metabolism 299 2010 E947 952
116. S. Schmidt, E. Moric, M. Schmidt, M. Sastre, D.L. Feinstein, and M.T. Heneka Anti-inflammatory and antiproliferative actions of PPAR-{gamma} agonists on T lymphocytes derived from MS patients Journal of Leukocyte Biology 2003
117. M. Schubert, D.P. Brazil, D.J. Burks, J.A. Kushner, J. Ye, C.L. Flint, J. Farhang-Fallah, P. Dikkes, X.M. Warot, C. Rio, G. Corfas, and M.F. White Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation Journal of Neuroscience 23 2003 7084 7092 (Pubitemid 36975873)
118. M. Schubert, D. Gautam, D. Surjo, K. Ueki, S. Baudler, D. Schubert, T. Kondo, J. Alber, N. Galldiks, E. Kustermann, S. Arndt, A.H. Jacobs, W. Krone, C.R. Kahn, and J.C. Bruning Role for neuronal insulin resistance in neurodegenerative diseases Proceedings of the National Academy of Sciences of the United States of America 101 2004 3100 3105 (Pubitemid 38327741)
119. R.J. Schulingkamp, T.C. Pagano, D. Hung, and R.B. Raffa Insulin receptors and insulin action in the brain: review and clinical implications Neuroscience & Biobehavioral Reviews 24 2000 855 872
120. M.W. Schwartz, D.F. Figlewicz, S.E. Kahn, D.G. Baskin, M.R. Greenwood, and D. Porte Jr. Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats Peptides 11 1990 467 472 (Pubitemid 20186617)
121. M.T. Shipley Transport of molecules from nose to brain: transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium Brain Research Bulletin 15 1985 129 142 (Pubitemid 15017253)
122. J.S. Sidhu, D. Cowan, and J.C. Kaski The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients Journal of the American College of Cardiology 42 2003 1757 1763 (Pubitemid 37433654)
123. J.S. Sidhu, D. Cowan, and J.C. Kaski Effects of rosiglitazone on endothelial function in men with coronary artery disease without diabetes mellitus American Journal of Cardiology 94 2004 151 156 (Pubitemid 38902860)
124. V.A. Skeberdis, J. Lan, X. Zheng, R.S. Zukin, and M.V. Bennett Insulin promotes rapid delivery of N-methyl-d-aspartate receptors to the cell surface by exocytosis Proceedings of the National Academy of Sciences of the United States of America 98 2001 3561 3566 (Pubitemid 32220884)
125. C.C. Smith, and D.J. Betteridge Plasma beta-amyloid (A beta) 40 concentration, lipid status and age in humans Neuroscience Letters 367 2004 48 50 (Pubitemid 39078782)
126. J.A. Sonnen, E.B. Larson, K. Brickell, P.K. Crane, R. Woltjer, T.J. Montine, and S. Craft Different patterns of cerebral injury in dementia with or without diabetes Archives of Neurology 66 2009 315 322
127. U. Stockhorst, D. de Fries, H.J. Steingrueber, and W.A. Scherbaum Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans Physiology & Behavior 83 2004 47 54 (Pubitemid 39387693)
128. M.W. Strachan, R.M. Reynolds, B.M. Frier, R.J. Mitchell, and J.F. Price The relationship between type 2 diabetes and dementia British Medical Bulletin 88 2008 131 146
129. S. Sudoh, M.P. Frosch, and B.A. Wolf Differential effects of proteases involved in intracellular degradation of amyloid b-protein between detergent-soluble and -insoluble pools in CHO-695 cells Biochemistry 41 2002 1091 1099 (Pubitemid 34083761)
130. K. Talbot, H.Y. Wang, H. Kazi, L.Y. Han, K.P. Bakshi, A. Stucky, R.L. Fuino, K.R. Kawaguchi, A.J. Samoyedny, R.S. Wilson, Z. Arvanitakis, J.A. Schneider, B.A. Wolf, D.A. Bennett, J.Q. Trojanowski, and S.E. Arnold Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline The Journal of Clinical Investigation 122 2012 1316 1338
131. L. Tao, H.R. Liu, E. Gao, Z.P. Teng, B.L. Lopez, T.A. Christopher, X.L. Ma, I. Batinic-Haberle, R.N. Willette, E.H. Ohlstein, and T.L. Yue Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia Circulation 108 2003 2805 2811 (Pubitemid 37498984)
132. R.G. Thorne, G.J. Pronk, V. Padmanabhan, and W.H. Frey 2nd Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 127 2004 481 496 (Pubitemid 38950662)
133. R.S. Tilvis, M.H. Kahonen-Vare, J. Jolkkonen, J. Valvanne, K.H. Pitkala, and T.E. Strandberg Predictors of cognitive decline and mortality of aged people over a 10-year period Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59 2004 268 274 (Pubitemid 38375341)
134. A.M. Tolppanen, P. Lavikainen, A. Solomon, M. Kivipelto, M. Uusitupa, H. Soininen, and S. Hartikainen History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study Diabetes Care 2013
135. M. Townsend, T. Mehta, and D.J. Selkoe Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway Journal of Biological Chemistry 282 2007 33305 33312 (Pubitemid 350159548)
136. J.W. Unger, J.N. Livingston, and A.M. Moss Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects Progress in Neurobiology 36 1991 343 362
137. B. Vessby, M. Unsitupa, K. Hermansen, G. Riccardi, A.A. Rivellese, L.C. Tapsell, C. Nalsen, L. Berglund, A. Louheranta, B.M. Rasmussen, G.D. Calvert, A. Maffetone, E. Pedersen, I.B. Gustafsson, and L.H. Storlien Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study Diabetologia 44 2001 312 319 (Pubitemid 32234457)
138. B.J. Wallum, G.J. Taborsky Jr., D. Porte Jr., D.P. Figlewicz, L. Jacobson, J.C. Beard, W.K. Ward, and D. Dorsa Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man Journal of Clinical Endocrinology & Metabolism 64 1987 190 194 (Pubitemid 17015900)
139. G.S. Watson, B.A. Cholerton, M.A. Reger, L.D. Baker, S.R. Plymate, S. Asthana, M.A. Fishel, J.J. Kulstad, P.S. Green, D.G. Cook, S.E. Kahn, M.L. Keeling, and S. Craft Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study American Journal of Geriatric Psychiatry 13 2005 950 958 (Pubitemid 46638661)
140. R.A. Whitmer, D.R. Gustafson, E. Barrett-Connor, M.N. Haan, E.P. Gunderson, and K. Yaffe Central obesity and increased risk of dementia more than three decades later Neurology 71 2008 1057 1064
141. W. Xu, C. Qiu, M. Gatz, N.L. Pedersen, B. Johansson, and L. Fratiglioni Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study Diabetes 58 2009 71 77
142. L. Zhao, B. Teter, T. Morihara, G.P. Lim, S.S. Ambegaokar, O.J. Ubeda, S.A. Frautschy, and G.M. Cole Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention Journal of Neuroscience 24 2004 11120 11126 (Pubitemid 40012971)
143. W. Zhao, H. Chen, H. Xu, E. Moore, N. Meiri, M.J. Quon, and D.L. Alkon Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats Journal of Biological Chemistry 274 1999 34893 34902 (Pubitemid 129509536)