New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues

Journal of Medicinal Chemistry

Volumn 59, Issue 20, 2016, Pages 9350-9369

  Zimmermann, Louis ^a   Das, Indrajit ^a   Désiré, Jérôme ^a   Sautrey, Guillaume ^b   Vinicius Barros, R S ^a   El Khoury, Micheline ^b   Mingeot Leclercq, Marie Paule ^b   Décout, Jean Luc ^a  

^a Université Grenoble I   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3',4' DI O ( 1'' NONYL)NEAMINE; 3,4' DI O [ 3'' ( 2'' NAPHTHYL)PROPYL]NEAMINE; ALLYL 2 ACETAMIDO 6 AZIDO 2,6 DIDEOXY 3,4 DI O NONYL ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 2 ACETAMIDO 6 AZIDO 2,6 DIDEOXY 3,4 DI O [( 2 NAPHTHYL)PROPYL] ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 2 [ N ( TERT BUTOXYCARBONYL)ACETAMINO] 6 AZIDO 2,6 DIDEOXY 3,4 DI O [( 2 NAPHTHYL)PROPYL] ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 2 [ N (TERT BUTOXYCARBONYL)ACETAMIDO] 6 AZIDO 2,6 DIDEOXY 3,4 DI O NONYL ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 2,6 DIAMINO 2,6 DIDEOXY 3,4 DI O[( 2 NAPHTHYL)METHYL] ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 2,6 DIAMINO 2,6 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 6 AMINO 2 (TERT BUTOXYCARBONYLAMINO) 2,6 DIDEOXY 3,4 DI O [( 2 NAPHTHYL)PROPYL] ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 6 AMINO 2,6 DIDEOXY 2 N TRITYLAMINO ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 6 AZIDO 2 (TERT BUTOXYCARBONYLAMINO) 2,6 DIDEOXY 3,4 DI O NONYL ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 6 AZIDO 2 (TERT BUTOXYCARBONYLAMINO) 2,6 DIDEOXY 3,4 DI O [( 2 NAPHTHYL)PROPYL] ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 6 AZIDO 2,6 DIDEOXY 2 TRITYLAMINO ALPHA DEXTRO GLUCOPYRANOSIDE; ALLYL 6 AZIDO 2,6 DIDEOXY 3,4 DI O [( 2 NAPHTHYL)METHYL] 2 TRITYLAMINO ALPHA DEXTRO GLUCOPYRANOSIDE; ALPHA ALLYLNEOSAMINE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOGLYCOSIDE DERIVATIVE; AMPHOPHILE; ANTIBIOTIC AGENT; COLISTIN; FRAMYCETIN; GENTAMICIN; N ACETYLGLUCOSAMINE; NEAMINE; NEAMINE DERIVATIVE; NEOSAMINE; NEOSAMINE DERIVATIVE; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; GLUCOSAMINE; SURFACTANT;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; DRUG TARGETING; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; LIPOPHILICITY; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; FRAMYCETIN; GLUCOSAMINE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE-ACTIVE AGENTS;

EID: 84994030706     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00818     Document Type: Article

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