Aminoglycoside antibiotics: Structures, functions, and resistance

Advances in Experimental Medicine and Biology

Volumn 456, Issue , 1998, Pages 27-69

  Wright, G D ^a   Berghuis, A M ^a   Mobashery, S ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC G 418; APRAMYCIN; BUTIROSIN; DIBEKACIN; FRAMYCETIN; GENTAMICIN; GENTAMICIN C; HABEKACIN; HYGROMYCIN B; ISEPAMICIN; KANAMYCIN A; KANAMYCIN B; LIVIDOMYCIN; NEOMYCIN; NETILMICIN; NUCLEOTIDYLTRANSFERASE; PAROMOMYCIN; PHOSPHOTRANSFERASE; RIBOSTAMYCIN; SISOMICIN; SPECTINOMYCIN; STREPTOMYCIN; TOBRAMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL INFECTION; DNA MODIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS);

EID: 0032226544     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4897-3_4     Document Type: Review

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78. Site-specific mutations of conserved C-terminal residues in aminoglycoside 3′-phosphotransferase II: Phenotypic and structural analysis of mutant enzymes
79. Amino acid substitutions within the analogous nucleotide binding loop (P-loop) of aminoglycoside 3′-phosphotransferase-II
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82. Purification and characterization of chromosomal streptomycin adenyltransferase from derivatives of Bacillus subtilis Marburg 168
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91. Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus
92. AAC(1): A new aminoglycoside-acetylating enzyme modifying the Cl amino group of apramycin
93. Polyribosome depletion and blockage of the ribosome cycle by streptomycin in Escherichia coli
94. A spectinomycin resistance determinant from the spectinomycin producer Streptomyces flavopersicus
95. Identification and analysis of aarP, a transcriptional activator of the 2′-N-acetyltransferase in Providencia stuartii
96. aarD, a Providencia stuartii homologue of cydD: Role in 2′-N-acetyltransferase expression, cell morphology and growth in the presence of an extracellular factor
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98. Kinetic studies of aminoglycoside acetyltransferase and phosphotransferase from Staphylococcus aureus RPAL
99. Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: Evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes
100. Actinospectacin a new antibiotic. I. Discovery and biological properties
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102. Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110
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104. Completion of the nucleotide sequence of the central region of Tn5 confirms the presence of three resistance genes
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110. Overproducion of 3′-aminoglycoside phosphotransferase type I confers resistance to tobramycin in Escherichia coli
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113. Interaction of antibiotics with functional sites in 16S ribosomal RNA
114. Role of 2,6-dideoxy-2,6-diaminoglucose in activation of a eukaryotic phospholipase C by aminoglycoside antibiotics
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123. Nucleotide sequence of the kanamycin resistance transposon Tn903
124. Nucleotide sequences of streptococcal genes
125. Two structures of the catalytic domain of phosphorylase kinase: An active protein kinase complexed with substrate analogue and product
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129. Characterization of gentamicin 2′-N-acetyltransferase from Providencia stuartii: Its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan
130. Contribution of gentamicin 2′-N-acetyltransferase to the O-acetylation of peptidoglycan in Providencia stuartii
131. The role of O-acetylation in the metabolism of peptidoglycan in Providencia stuartii
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133. Antibiotic resistance by modification: Many resistance genes could be derived from cellular control genes in actinomycetes. - A hypothesis
134. Evolution of antibiotic resistance and production genes in streptomycetes
135. Formation of free radicals by gentamycin and iron and evidence for an iron/gentamicin complex
136. Substrate specificities and structure-activity relationships for acylation of antibiotics catalyzed by kanamycin acetyltransferase
137. The kinetic mechanism of kanamycin acetyltransferase derived from the use of alternative antibiotics and coenzymes
138. Purification of two forms of kanamycin acetyltransferase from Escherichia coli
139. m ratio of enzymatic modification of aminoglycosides by kanamycin acetyl-transferase
140. Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli
141. Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase
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143. Genetic analysis of bacterial acetyltransferases: Identification of amino acids determining the specificities of the aminoglycoside 6′-N-acetyltransferase Ib and IIa proteins
144. Characterization of aarA, a pleiotrophic negative regulator of the 2′-N-acetyltransferase in Providencia stuartii
145. Characterization and transcriptional regulation of the 2′-N-acetyltransferase gene from Providencia stuartii
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147. aarC, an essential gene involved in density-dependent regulation of the 2′-N-acetyltransferase in Providencia stuartii
148. Loss of individual electrostatic interactions between aminoglycoside antibiotics and resistance enzymes as an effective means to overcoming bacterial drug resistance
149. Mechanism-based inactivation of bacterial aminoglycoside 3′-phosphotransferases
150. The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: Expression and nucleotide sequence analysis
151. Molecular structure of kanamycin nucleotidyl transferase determined to 3Å resolution
152. Isolation and characterization of and aminoglycoside phosphotransferase from neomycin-producing Micromonospora chalcea: Comparison with that of Streptomyces fradiae and other producers of 4,6-disubstituted 3-deoxystreptamine antibiotics
153. Characterization of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae
154. Lack of in vivo evidence of a cytochrome P450 metabolite participating in aminoglycoside nephrotoxicity
155. Cloning of aminoglycoside phosphotransferase (APH) gene from antibiotic-producing strain of Bacillus circulans into a high-expression vector, pK223-3. Purification, properties and location of the enzyme
156. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism
157. Biochemical basis of aminoglycoside ototoxicity
158. Streptomycin, a substance exibiting antibiotic activity against Gram-positive and Gram-negative bacteria
159. Failure of aminoglycoside antibiotics to kill anaerobic, low-pH, and resistant cultures
160. Nucleotide sequence analysis of 2″-aminoglycoside nucleotidyl-transferase ANT(2″) from Tn4000: Its relationship with AAD(3″) and impact on Tn21 evolution
161. Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010
162. Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-lb, from Pseudomonas aeruginosa
163. Isolation, characterization, and DNA sequence analysis of an AAC(6′)-II gene from Pseudomonas aeruginosa
164. Characterization of the chromosomal aac(6′)-lc gene from Serratia marcescens
165. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes
166. Studies on antibiotic SF-733, a new antibiotic. I. Taxonomy, isolation and characterization
167. Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli
168. Purification and characterization of aminoglycoside 3′-phosphotransferase Type IIa and kinetic comparison with a new mutant enzyme
169. Purification, characterization, and investigation of the mechanism of aminoglycoside 3′-phosphotransferase Type Ia
170. Cloning of aminoglycoside-resistance determinants from Streptomyces tenebrarius and comparison with related genes from other actinomycetes
171. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo
172. Dissemination of the strA-strB streptomycin-resistance genes among commensal and pathogenic bacteria from, humans, animals, and plants
173. Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila
174. β-lactamase inhibitors and reversal of antibiotic resistance
175. Bacterial uptake of aminoglycoside antibiotics
176. Inhibition of initiation of DNA synthesis by aminoglycoside antibiotics
177. Photo-induced labelling of Escherichia coli ribosomes by a tobramycin analog
178. Genetic characterization of kanamycin resistance in Campylobacter coli
179. Structural framework for the protein kinase family
180. Cloning and sequencing of a gene encoding an aminoglycoside 6′-N-acetyltransferase from an R factor of Citrobacter diversus
181. Nucleotide sequence of a novel kanamycin resistance gene, aphA-7, from Campylobacter jejuni and comparison to other kanamycin phosphotransferase genes
182. Development of a DNA probe from the deoxyribonucleotide sequence of a 3-N-aminoglycoside acetyltransferase [AAC(3)-I] resistance gene
183. Cloning, sequencing, and use as a molecular probe of a gene encoding an aminoglycoside 6′-N-acetyltransferase of broad substrate profile
184. Molecular characterization of highly gentamicin-resistant Enterococcus faecalis isolates lacking high-level streptomycin resistance
185. Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids
186. DNA cloning in Streptomyces: Resistance genes from antibiotic-producing species
187. Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea
188. Mechanism of aminoglycoside 3′-phosphotransferase type IIIa: His188 is not a phosphate-accepting-residue
189. Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3′)-IIIa)
190. Primary structure of an aminoglycoside 6′-N-acetyltransferase AAC(6prime;)-4, fused in vivo with the signal peptide of the Tn3-encoded $-lactamase
191. Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3′5″-aminoglycoside phosphotransferase type III
192. Purification and characterization of aminoglycoside-modifying enzymes from Staphylococcus aureus and Staphylococcus epidermidis
193. Syntheses of 6′-N-methyl-kanamycin and 3′,4′-dideoxy-6′-N-methylkanamycin B active against resistant strains having 6′-N-acetylating enzymes
194. Production and isolation of a new antibiotic kanamycin
195. Nucleotide sequence of aacC2 gene from a clinical strain of Escherichia coli
196. Gentamicin nucleotidyltransferase. Stereochemical inversion at phosphorus in enzymatic 2′-deoxyadenylyl transfer to tobramycin
197. Purification and properties of gentamicin nucleotidyltransferase from Escherichia coli: Nucleotide specificity, pH optimum, and the separation of two electrophoretic variants
198. 31P nuclear magnetic resonance spectral assignments for tobramycin, 2″-(adenosine-5′-phosphoryl)-tobramycin and 2″-(adenosine-5′-thiophosphoryl)-tobramycin
199. Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae
200. Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli
201. Characterisation of the hydroxystreptomycin phosphotransferase gene (sph) of Streptomyces glaucescens: Nucleotide sequence and promoter analysis
202. Neomycin, a new antibiotic active against streptomycin-resistant bacteria, including tuberculosis organisms
203. Specificity of aminoglycoside binding to RNA constructs derived from the 16S rRNA deconding region an the HIV-RRE activator region
204. Gentamicin, a new antibiotic complex from Micromonospora
205. Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic
206. A non-canonical base pair within the human immunodeficiency virus Rev-responsive element is involved in both Rev and small molecule recognition
207. Purification and properties of gentamincin acetyltransferase I
208. Kinetic mechanism of gentamicin acetyltransferase I
209. Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I
210. Synthesis of a tight-binding, multisubstrate analog inhibitor of gentamicin acetyltransferase
211. Butirosins A and B, aminoglycoside antibiotics. I. Structural units
212. Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA
213. Overexpression and characterization of the chromosomal aminoglycoside 6′-N-acetyltransferase from Enterococcus faecium
214. Cloning and characterization of an aminoglycoside 6′-N-acetyltransferase gene from Citrobacter freundii which confers an altered resistance profile
215. Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors
216. A mutant neomycin phosphotransferase II gene reduces the resistance of transformants to antibiotic selection pressure
217. Role of Pseudomonas aeruginosa outer membrane protein OprH in polymyxin and gentamicin resistance: Isolation of an OprH-deficient mutant by gene replacement techniques
218. Nucleotide sequence of the hygromycin B phosphotransferase gene from Streptomyces hygroscopicus
219. Cloning and expression in Escherichia coli of a hygromycin B phosphotransferase gene from Streptomyces hygroscopicus
220. Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus
221. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production
222. Bacterial signalling involving eukaryotic-type protein kinases
223. Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
224. Is there a catalytic base in the active site of cAMP-dependent protein kinase?