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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 7097-7101

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

(9) Hanessian, Stephen a Pachamuthu, Kandasamy a Szychowski, Janek a Gigure, Alexandre a Swayze, Eric E b Migawa, Michael T b François, Boris c Kondo, Jiro c,d Westhof, Eric c

a UNIVERSITÉ DE MONTRÉAL (Canada)

b ISIS PHARMACEUTICALS (United States)

c UNIVERSITÉ DE STRASBOURG (France)

d SOPHIA UNIVERSITY (Japan)

Author keywords

Aminoglycoside; Antibiotic resistance; RNA complex

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BUTIROSIN; FRAMYCETIN; HABEKACIN; KANAMYCIN A; PAROMOMYCIN; RIBOSOME RNA; TOBRAMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIA; CRYSTALLIZATION; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; RNA, RIBOSOMAL;

EID: 78149282652 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.09.084 Document Type: Article

Times cited : (39)

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