A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription

Journal of Medicinal Chemistry

Volumn 55, Issue 13, 2012, Pages 6021-6032

  Das, Indrajit ^a   Désiré, Jérôme ^a   Manvar, Dinesh ^b   Baussanne, Isabelle ^a   Pandey, Virendra N ^b   Décout, Jean Luc ^a  

^a UNIV GRENOBLE ALPES   (France)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINO DEXTRO GLUCOSAMINE; FRAMYCETIN; GLUCOSAMINE; PEPTIDE NUCLEIC ACID; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOSOL; DRUG CONJUGATION; DRUG STABILITY; DRUG UPTAKE; ENDOSOME; GENETIC TRANSCRIPTION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; TRANSACTIVATION; VIRUS INHIBITION;

ACETYLGLUCOSAMINE; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; BINDING SITES; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CELL NUCLEUS; CYTOSOL; ENDOSOMES; FLUORESCEIN-5-ISOTHIOCYANATE; FRAMYCETIN; GENOME, VIRAL; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; PEPTIDE NUCLEIC ACIDS; RESPONSE ELEMENTS; RNA, VIRAL; SPECTROMETRY, FLUORESCENCE; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84863824452     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300253q     Document Type: Article

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