Antibiotic drugs aminoglycosides cleave DNA at abasic sites: Shedding new light on their toxicity?

Chemical Research in Toxicology

Volumn 26, Issue 11, 2013, Pages 1710-1719

  Perigolo De Oliveira, Maralise ^a   Constant, Jean François ^b   Peuchmaur, Marine ^a   Pitta, Ivan ^c   Décout, Jean Luc ^a  

^a Université Grenoble I   (France)

^b Centre National de la Recherche Scientifique   (France)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC G 418; DNA; FRAMYCETIN; GENTAMICIN C; KANAMYCIN; KANAMYCIN A; NEAMINE; PAROMOMYCIN; PLASMID DNA; RIBOSTAMYCIN; TOBRAMYCIN;

APURINIC SITE; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; DNA ALKYLATION; DNA CLEAVAGE; DNA DAMAGE; DRUG MECHANISM; DRUG STRUCTURE; DRUG TOXICITY; PROTON TRANSPORT;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; DNA; DNA CLEAVAGE; FRAMYCETIN; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; PHOSPHORUS RADIOISOTOPES; PLASMIDS;

EID: 84888056643     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx4002836     Document Type: Article

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