Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7738-7745

  Yin, Lois M ^a,b   Edwards, Michelle A ^c   Li, Jessica ^c   Yip, Christopher M ^b,c   Deber, Charles M ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL ACTIVITY; BACTERIAL LIPIDS; BACTERIAL MEMBRANES; CATIONIC ANTIMICROBIAL PEPTIDES; CD SPECTROSCOPY; CONCENTRATION RANGES; HUMAN ERYTHROCYTES; INNATE IMMUNITY; LOWER HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; MODEL MEMBRANES; OPTIMUM ROUTE; PEPTIDE-MEMBRANE INTERACTIONS; POSITIVE CHARGES; PSEUDOMONAS AERUGINOSA; SDS-PAGE; SELF AGGREGATION; TIME-DEPENDENT;

ATOMIC FORCE MICROSCOPY; BLOOD; CELL DEATH; CHARGE DISTRIBUTION; CIRCULAR DICHROISM SPECTROSCOPY; DRUG INTERACTIONS; HYDROPHOBICITY; MAMMALS; PEPTIDES; POLYPEPTIDES;

MEMBRANES;

ALANINE; LEUCINE; LYSINE; PEPTIDE 3K F17 3K; PEPTIDE 3K F17 4L 3K; PEPTIDE 6K F17; PEPTIDE 6K F17 4L; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; ATOMIC FORCE MICROSCOPY; BACTERIAL MEMBRANE; BIOLOGICAL ACTIVITY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DRUG BINDING; DRUG EFFICACY; DRUG PENETRATION; DRUG PURIFICATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR INTERACTION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PSEUDOMONAS AERUGINOSA; STRUCTURE ANALYSIS;

ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; ERYTHROCYTE MEMBRANE; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANES, ARTIFICIAL; PROTEIN STRUCTURE, SECONDARY;

BACTERIA (MICROORGANISMS); MAMMALIA; PSEUDOMONAS AERUGINOSA;

EID: 84863230302     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.303602     Document Type: Article

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