Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: Role of the number of rings and positive charges in the specific binding leading to miscoding

Nucleic Acids Research

Volumn 33, Issue 17, 2005, Pages 5677-5690

  François, Boris ^b   Russell, Rupert J M ^a   Murray, James B ^a   Aboul ela, Fareed ^a,c   Masquida, Benoît ^b   Vicens, Quentin ^b,d   Westhof, Eric ^b  

^a Vernalis PLC   (United Kingdom)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERIAL RNA; FRAMYCETIN; GENTAMICIN; HYDROGEN; KANAMYCIN A; LIVIDOMYCIN; NEAMINE; OLIGONUCLEOTIDE; RIBOSTAMYCIN; ADENINE; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; GENTAMICIN C; KANAMYCIN; LIVIDOMYCINS; OLIGORIBONUCLEOTIDE; PAROMOMYCIN; RNA 16S;

ARTICLE; BASE PAIRING; BINDING KINETICS; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; ANTICODON; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CODON; NUCLEOTIDE SEQUENCE; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ADENINE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTICODON; BASE SEQUENCE; BINDING SITES; CODON; CRYSTALLOGRAPHY, X-RAY; FRAMYCETIN; GENTAMICINS; KANAMYCIN; MODELS, MOLECULAR; OLIGORIBONUCLEOTIDES; PAROMOMYCIN; RIBOSOMES; RIBOSTAMYCIN; RNA, RIBOSOMAL, 16S;

EID: 27244458194     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki862     Document Type: Article

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