Albumin binding of short cationic antimicrobial micropeptides and its influence on the in vitro bactericidal effect

Journal of Medicinal Chemistry

Volumn 50, Issue 14, 2007, Pages 3334-3339

  Svenson, Johan ^a   Brandsdal, Bjørn Olav ^a   Stensen, Wenche ^a,b   Svendsen, John S ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b LYTIX BIOPHARMA AS   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTIINFECTIVE AGENT; CATIONIC ANTIBACTERIAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN BINDING; STAPHYLOCOCCUS AUREUS;

ALBUMINS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICE; MICROBIAL SENSITIVITY TESTS; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STAPHYLOCOCCUS AUREUS;

EID: 34447544341     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0703542     Document Type: Article

References (22)

1. Peters, T. Serum Albumin. Adv. Protein Chem. 1985, 37, 161-245.
2. He, X. M.; Carter, D. C. Atomic structure and chemistry of human serum albumin. Nature 1992, 358, 209-215.
3. Sudlow, G.; Birkett, D. J.; Wade, D. N. Characterization of two specific drag binding sites on human serum albumin. Mol. Pharmacol. 1975, 11, 824-832.
4. Ghuman, J.; Zunszain, P. A.; Petitpas, I.; Bhattacharya, A. A.; Otagiri, M.; Curry, S. Structural basis of the drug-binding specificity of human serum albumin. J. Mol. Biol. 2005, 353, 38-52.
5. Kratochwil, N. A.; Huber, W.; Muller, F.; Kansy, M.; Gerber, P. R. Predicting plasma protein binding of drugs: a new approach. Biochem. Pharmacol. 2002, 64, 1355-1374.
6. Hancock, R. E. W. Host defense (Cationic) peptides. What is their future clinical potential? Drugs 1999, 57, 469-473.
7. Strøm, M. B.; Haug, B. E.; Skar, M. L.; Stensen, W.; Stiberg, T.; Svendsen, J. S. The pharmacophore of short cationic antibacterial peptides. J. Med. Chem. 2003, 46, 1567-1570.
8. Haug, B. E.; Stensen, W.; Stiberg, T.; Svendsen, J. S. Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides. J. Med. Chem. 2004, 47, 4159-4162.
9. Haug, B. E.; Skar, M. L.; Svendsen, J. S. Bulky aromatic amino acids increase the antibacterial activity of 15-residue bovine lactoferricin derivatives. J. Pept. Sci. 2001, 7, 425-432.
10. Strøm, M. B.; Rekdal, Ø.; Svendsen, J. S. Antimicrobial activity of short arginine- and tryptophan-rich peptides. J. Pept. Sci. 2002, 8, 431-437.
11. Vorland, L. H.; Ulvatne, H.; Rekdal, Ø.; Svendsen, J. S. Initial binding sites of antimicrobial peptides in Staphylococcus aureus and Escherichia coli. Scand. J. Infect. Dis. 1999, 31, 467-473.
12. Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415, 389-395.
13. Leavitt, S.; Freire, E. Direct measurement of protein binding energetics by isothermal titration calorimetry. Curr. Opin. Struct. Biol. 2001, 11, 560-566.
14. Thomson, J. A.; Ladbury, J. E. Isothermal titration calorimetry: a Tutorial. In Biocalorimetry 2; Ladbury, J. E.; Doyle, M. L., Eds.; Wiley & Sons Ltd.: Chicester, 2004; pp 37-58.
15. Perozzo, R.; Folkers, G.; Scapozza, L. Thermodynamics of protein-ligand interactions: History, presence, and future aspects. J. Rec. Sign. Trans. 2004, 24, 1-52.
16. Ward, W. H. J.; Holdgate, G. A. Isothermal titration calorimetry in drug discovery. Prog. Med. Chem. 2001, 38, 309-376.
17. Kragh-Hansen, U. Molecular aspects of ligand binding to serum albumin. Pharmacol. Rev. 1981, 33, 17-53.
18. Kragh-Hansen, U.; Chuang, V. T. G.; Otagiri, M. Practical aspects of the ligand-binding and enzymatic properties of human serum albumin. Biol. Pharm. Bull. 2002, 25, 695-704.
19. Menezo, Y.; Khatchadourian, C. Peptides bound to albumin. Life Sci. 1986, 39, 1751-1753.
20. Amsterdam, D. Susceptibility testing of antimicrobials in liquid media. In Antibiotics in laboratory medicine, 4th ed.; Lorian V, Ed.; Williams and Wilkins.: Philadelphia, 1996; pp 75-78.
21. Mao, H.; Hajduk, P. J.; Craig, R.; Bell, R.; Borre, T.; Fesik, S. W. Rational design of diflunsial analogues with reduced affinity for human serum albumin. J. Am. Chem. Soc. 2001, 123, 10429-10435.
22. Coste, J.; Frérot, E.; Jouin, P. Coupling N-methylated amino acids using PyBroP and PyCloP halogenophosphonium salts: Mechanism and fields of application. J. Org. Chem. 1994, 59, 2437-2446.