Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs'

ACS Chemical Biology

Volumn 9, Issue 5, 2014, Pages 1172-1177

  Velkov, Tony ^a   Roberts, Kade D ^a   Nation, Roger L ^a   Wang, Jiping ^a   Thompson, Philip E ^a   Li, Jian ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COLISTIN; FADDI 002; FADDI 003; FADDI 016; FADDI 017; FADDI 018; FADDI 019; FADDI 020; FADDI 021; FADDI 031; FADDI 036; FADDI 039; FADDI 040; FADDI 047; FADDI 063; FADDI 064; LIPOPOLYSACCHARIDE; POLYMYXIN B; POLYMYXIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; POLYMYXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL OUTER MEMBRANE; DRUG CLEARANCE; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; GRAM NEGATIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LUNG INFECTION; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NEPHROTOXICITY; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMAN; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; POLYMYXINS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84900839248     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500080r     Document Type: Article

References (30)

1. Ainsworth, G. C., Brown, A. M., and Brownlee, G. (1947) Aerosporin, an antibiotic produced by Bacillus aerosporus Greer Nature 159, 263
2. Li, J., Nation, R. L., Milne, R. W., Turnidge, J. D., and Coulthard, K. (2005) Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria Int. J. Antimicrob. Agents 25, 11-25
3. Falagas, M. E., Rafailidis, P. I., Matthaiou, D. K., Virtzili, S., Nikita, D., and Michalopoulos, A. (2008) Pandrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii infections: Characteristics and outcome in a series of 28 patients Int. J. Antimicrob. Agents 32, 450-454
4. Valencia, R., Arroyo, L. A., Conde, M., Aldana, J. M., Torres, M. J., Fernandez-Cuenca, F., Garnacho-Montero, J., Cisneros, J. M., Ortiz, C., Pachon, J., and Aznar, J. (2009) Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital Infect. Control Hosp. Epidemiol. 30, 257-263
5. Bergen, P. J., Bulitta, J. B., Forrest, A., Tsuji, B. T., Li, J., and Nation, R. L. (2010) Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model Antimicrob. Agents Chemother. 54, 3783-3789
6. Li, J., Nation, R. L., Turnidge, J. D., Milne, R. W., Coulthard, K., Rayner, C. R., and Paterson, D. L. (2006) Colistin: The re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections Lancet Infect. Dis. 6, 589-601
7. Poudyal, A., Howden, B. P., Bell, J. M., Gao, W., Owen, R. J., Turnidge, J. D., Nation, R. L., and Li, J. (2008) In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae J. Antimicrob. Chemother. 62, 1311-1318
8. Capone, A., Giannella, M., Fortini, D., Giordano, A., Meledandri, M., Ballardini, M., Venditti, M., Bordi, E., Capozzi, D., Balice, M. P., Tarasi, A., Parisi, G., Lappa, A., Carattoli, A., and Petrosillo, N. (2013) High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality Clin. Microbiol. Infect. 19, E23-E30
9. Chen, J. M. e. a. Polymyxin derivatives useful as antibacterial agents. WO 2012/168820 A1, 2012.
10. Curran, W. V. e. a. Antibiotic compositions for the treatment of Gram-negative infections. US 8415307 B1, 2013.
11. Leese, R. A. Antibiotic composition for the treatment of Gram-negative infections. US 2010/0160215 A1, 2010.
12. Vaara, M. a. V. T Short fatty acid tail polymyxin derivatives and uses thereof. WO 2009/098357 A1, 2009.
13. Velkov, T., Thompson, P. E., Nation, R. L., and Li, J. (2010) Structure-activity relationships of polymyxin antibiotics J. Med. Chem. 53, 1898-1916
14. Velkov, T., Roberts, K. D., Nation, R. L., Thompson, P. E., and Li, J. (2013) Pharmacology of polymyxins: New insights into an old class of antibiotics Future Microbiol. 8, 711-724
15. Clements, A., Tull, D., Jenney, A. W., Farn, J. L., Kim, S. H., Bishop, R. E., McPhee, J. B., Hancock, R. E., Hartland, E. L., Pearse, M. J., Wijburg, O. L., Jackson, D. C., McConville, M. J., and Strugnell, R. A. (2007) Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides J. Biol. Chem. 282, 15569-15577
16. Moskowitz, S. M. and Ernst, R. K. (2010) The role of Pseudomonas lipopolysaccharide in cystic fibrosis airway infection Subcell Biochem 53, 241-253
17. Moskowitz, S. M., Ernst, R. K., and Miller, S. I. (2004) PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A J. Bacteriol. 186, 575-579
18. Hancock, R. E. (1997) Peptide antibiotics Lancet 349, 418-422
19. Koike, M., Iida, K., and Matsuo, T. (1969) Electron microscopic studies on mode of action of polymyxin J. Bacteriol. 97, 448-452
20. Velkov, T., Deris, Z. Z., Huang, J. X., Azad, M. A., Butler, M., Sivanesan, S., Kaminskas, L. M., Dong, Y. D., Boyd, B., Baker, M. A., Cooper, M. A., Nation, R. L., and Li, J. (2013) Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae Innate Immun. 10.1177/1753425913493337
21. Velkov, T., Soon, R. L., Chong, P. L., Huang, J. X., Cooper, M. A., Azad, M. A., Baker, M. A., Thompson, P. E., Roberts, K., Nation, R. L., Clements, A., Strugnell, R. A., and Li, J. (2012) Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A Innate Immun. 19, 265-277
22. Soon, R. L., Velkov, T., Chiu, F., Thompson, P. E., Kancharla, R., Roberts, K., Larson, I., Nation, R. L., and Li, J. (2011) Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin- lipopolysaccharide binding interactions Anal. Biochem. 409, 273-283
23. Li, J., Milne, R. W., Nation, R. L., Turnidge, J. D., Smeaton, T. C., and Coulthard, K. (2003) Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration Antimicrob. Agents Chemother. 47, 1766-1770
24. Yousef, J. M., Chen, G., Hill, P. A., Nation, R. L., and Li, J. (2012) Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics J. Antimicrob. Chemother. 67, 452-459
25. Wayne, P. A. C. (2013) Performance Standards for Antimicrobial Susceptibility Testing; Twenty-third Informational Supplement M100-S23
26. Li, J., Rayner, C. R., Nation, R. L., Owen, R. J., Tan, K. E., and Spelman, D. (2006) Hetero-resistance to colistin in multidrug-resistant Acinetobacter baumannii Antimicrob. Agents Chemother. 50, 2946-2950
27. Lee, C. H. and Tsai, C. M. (1999) Quantification of bacterial lipopolysaccharides by the purpald assay: Measuring formaldehyde generated from 2-keto-3-deoxyoctonate and heptose at the inner core by periodate oxidation Anal. Biochem. 267, 161-168
28. Li, J., Milne, R. W., Nation, R. L., Turnidge, J. D., Smeaton, T. C., and Coulthard, K. (2004) Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate J. Antimicrob. Chemother. 53, 837-840
29. Zavascki, A. P., Goldani, L. Z., Cao, G. Y., Superti, S. V., Lutz, L., Barth, A. L., Ramos, F., Boniatti, M. M., Nation, R. L., and Li, J. (2008) Pharmacokinetics of intravenous polymyxin B in critically ill patients Clin. Infect. Dis. 47, 1298-1304
30. Dudhani, R. V., Turnidge, J. D., Coulthard, K., Milne, R. W., Rayner, C. R., Li, J., and Nation, R. L. (2010) Elucidation of the pharmacokinetic/ pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models Antimicrob. Agents Chemother. 54, 1117-1124