Special Challenges to the Rational Design of Antibacterial Agents

Annual Reports in Medicinal Chemistry

Volumn 48, Issue , 2013, Pages 283-298

  Hevener, Kirk E ^a   Cao, Shuyi ^b   Zhu, Tian ^b   Su, Pin Chih ^b   Mehboob, Shahila ^b   Johnson, Michael E ^b  

^a IDAHO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

ADMET; Antibacterial; Cell penetration; Efflux; Rational design; Resistance

Indexed keywords

AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; BACTERIUM LIPOPOLYSACCHARIDE; BETA LACTAMASE INHIBITOR; CAPSAICIN DERIVATIVE; DS8587; POLYMYXIN; QUINOLONE DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL; BACTERIAL CELL WALL; COMBINATORIAL LIBRARY; COMPUTER MODEL; DNA REPLICATION; DRUG ABSORPTION; DRUG DESIGN; DRUG PENETRATION; ENZYME INACTIVATION; ESCHERICHIA COLI; GENE MUTATION; GRAM NEGATIVE BACTERIUM; HIGH THROUGHPUT SCREENING; HUMAN; LIPOPHILICITY; MOLECULAR DOCKING; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; PSEUDOMONAS AERUGINOSA;

EID: 84884133660     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-417150-3.00018-1     Document Type: Chapter

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