Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

Cell Reports

Volumn 13, Issue 10, 2015, Pages 2048-2055

  Siegert, Isabel ^a   Schödel, Johannes ^a   Nairz, Manfred ^b   Schatz, Valentin ^c   Dettmer, Katja ^d   Dick, Christopher ^c   Kalucka, Joanna ^a   Franke, Kristin ^e   Ehrenschwender, Martin ^c   Schley, Gunnar ^a   Beneke, Angelika ^f   Sutter, Jörg ^a   Moll, Matthias ^a   Hellerbrand, Claus ^d   Wielockx, Ben ^e   Katschinski, Dörthe M ^f   Lang, Roland ^a   Galy, Bruno ^g   Hentze, Matthias W ^h   Koivunen, Peppi ⁱ   Oefner, Peter J ^d   Bogdan, Christian ^a   Weiss, Günter ^b   Willam, Carsten ^a   Jantsch, Jonathan ^a,c   more..

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^f UNIVERSITY OF GÖTTINGEN   (Germany)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^h EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

ⁱ UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; FERRITIN; FUMARIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; REACTIVE OXYGEN METABOLITE; SUCCINIC ACID; HIF1A PROTEIN, MOUSE; IRON;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IRON METABOLISM; IRON STORAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; ANIMAL; ATOMIC ABSORPTION SPECTROMETRY; C57BL MOUSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLAMMATION; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERRITINS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; IRON; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXYGEN; PROLYL HYDROXYLASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY, ATOMIC; TANDEM MASS SPECTROMETRY;

EID: 85027948564     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.11.005     Document Type: Article

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