Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTORsignaling

International Journal of Nanomedicine

Volumn 11, Issue , 2016, Pages 5257-5276

  Guo, Caixia ^a   Yang, Man ^a   Jing, Li ^a   Wang, Ji ^a   Yu, Yang ^a   Li, Yang ^a   Duan, Junchao ^a   Zhou, Xianqing ^a   Li, Yanbo ^a   Sun, Zhiwei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cytotoxicity; Mechanism; Nanoparticle; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; CELL MARKER; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN LC3; PROTEIN P62; REACTIVE OXYGEN METABOLITE; SILICA NANOPARTICLE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MITOGEN ACTIVATED PROTEIN KINASE 1; MTOR PROTEIN, HUMAN; NANOPARTICLE; SILICON DIOXIDE; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME RELEASE; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

APOPTOSIS; AUTOPHAGY; BIOMARKERS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME ACTIVATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; NANOPARTICLES; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SILICON DIOXIDE; TOR SERINE-THREONINE KINASES;

EID: 84991661127     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S112030     Document Type: Article

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