메뉴 건너뛰기




Volumn 24, Issue 137, 2015, Pages 451-461

Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: A meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CORTICOSTEROID; PLACEBO; BRONCHODILATING AGENT;

EID: 84940663022     PISSN: 09059180     EISSN: 16000617     Source Type: Journal    
DOI: 10.1183/16000617.00002215     Document Type: Review
Times cited : (157)

References (38)
  • 1
    • 84895803870 scopus 로고    scopus 로고
    • Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): A randomised, double-blind placebo-controlled trial
    • Zheng JP, Wen FQ, Bai CX, et al. Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial. Lancet Respir Med 2014; 2: 187-194.
    • (2014) Lancet Respir Med , vol.2 , pp. 187-194
    • Zheng, J.P.1    Wen, F.Q.2    Bai, C.X.3
  • 2
    • 84895782525 scopus 로고    scopus 로고
    • N-acetylcysteine in COPD may be beneficial, but for whom?
    • Cazzola M, Matera MG. N-acetylcysteine in COPD may be beneficial, but for whom? Lancet Respir Med 2014; 2: 166-167.
    • (2014) Lancet Respir Med , vol.2 , pp. 166-167
    • Cazzola, M.1    Matera, M.G.2
  • 3
    • 20944433417 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): A randomized placebo-controlled trial
    • Decramer M, Rutten-van Mölken M, Dekhuijzen PN, et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomized placebo-controlled trial. Lancet 2005; 365: 1552-1560.
    • (2005) Lancet , vol.365 , pp. 1552-1560
    • Decramer, M.1    Rutten-Van Mölken, M.2    Dekhuijzen, P.N.3
  • 4
    • 0034023927 scopus 로고    scopus 로고
    • Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials
    • Grandjean EM, Berthet P, Ruffmann R, et al. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther 2000; 22: 209-221.
    • (2000) Clin Ther , vol.22 , pp. 209-221
    • Grandjean, E.M.1    Berthet, P.2    Ruffmann, R.3
  • 5
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral N-acetylcysteine in chronic bronchitis: A quantitative systematic review
    • Stey C, Steurer J, Bachmann S, et al. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J 2000; 16: 253-262.
    • (2000) Eur Respir J , vol.16 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3
  • 6
    • 84900801448 scopus 로고    scopus 로고
    • Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: A systematic review and meta-analysis
    • Shen Y, Cai W, Lei S, et al. Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis. COPD 2014; 11: 351-358.
    • (2014) COPD , vol.11 , pp. 351-358
    • Shen, Y.1    Cai, W.2    Lei, S.3
  • 7
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097.
    • (2009) Plos Med , vol.6
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 8
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
    • Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932-946.
    • (2004) Eur Respir J , vol.23 , pp. 932-946
    • Celli, B.R.1    Macnee, W.2
  • 10
    • 34147214922 scopus 로고    scopus 로고
    • Global Initiative for Chronic Obstructive Lung Disease
    • Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of COPD. www.goldcopd.org/guidelines-global-strategy-for-diagnosis-management.html Date last accessed: March, 2015. Date last updated: January, 2015.
    • (2015) Global Strategy for the Diagnosis, Management and Prevention of COPD
  • 11
    • 84883366780 scopus 로고    scopus 로고
    • Retrieving clinical evidence: A comparison of PubMed and Google Scholar for quick clinical searches
    • Shariff SZ, Bejaimal SA, Sontrop JM, et al. Retrieving clinical evidence: a comparison of PubMed and Google Scholar for quick clinical searches. J Med Internet Res 2013; 15: e164.
    • (2013) J Med Internet Res , vol.15
    • Shariff, S.Z.1    Bejaimal, S.A.2    Sontrop, J.M.3
  • 12
    • 33845619406 scopus 로고    scopus 로고
    • N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease
    • Sutherland ER, Crapo JD, Bowler RP. N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD 2006; 3: 195-202.
    • (2006) COPD , vol.3 , pp. 195-202
    • Sutherland, E.R.1    Crapo, J.D.2    Bowler, R.P.3
  • 13
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 15
    • 33750521816 scopus 로고    scopus 로고
    • DeCoster J. Meta-analysis Notes. www.stat-help.com/notes.html Date last accessed: March, 2015. Date last updated: September, 2004.
    • (2015) Meta-Analysis Notes
    • Decoster, J.1
  • 16
    • 84893822409 scopus 로고    scopus 로고
    • Meta-methodology: Conducting and reporting meta-analyses
    • Turner JR, Durham TA. Meta-methodology: conducting and reporting meta-analyses. J Clin Hypertens (Greenwich) 2014; 16: 91-93.
    • (2014) J Clin Hypertens (Greenwich) , vol.16 , pp. 91-93
    • Turner, J.R.1    Durham, T.A.2
  • 17
    • 84863847959 scopus 로고    scopus 로고
    • Closing the gap between methodologists and end-users: R as a computational back-end
    • Wallace BC, Dahabreh IJ, Trikalinos TA, et al. Closing the gap between methodologists and end-users: R as a computational back-end. J Stat Softw 2012; 49: 1-15.
    • (2012) J Stat Softw , vol.49 , pp. 1-15
    • Wallace, B.C.1    Dahabreh, I.J.2    Trikalinos, T.A.3
  • 18
    • 77958110812 scopus 로고    scopus 로고
    • Conducting meta-analyses in R with the metafor package
    • Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw 2012; 36: 1-48.
    • (2012) J Stat Softw , vol.36 , pp. 1-48
    • Viechtbauer, W.1
  • 19
    • 0028040727 scopus 로고
    • Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis
    • Hansen NC, Skriver A, Brorsen-Riis L, et al. Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis. Respir Med 1994; 88: 531-535.
    • (1994) Respir Med , vol.88 , pp. 531-535
    • Hansen, N.C.1    Skriver, A.2    Brorsen-Riis, L.3
  • 20
    • 84880047842 scopus 로고    scopus 로고
    • High-dose N-acetylcysteine in stable COPD: The 1-year, double-blind, randomized, placebo-controlled HIACE study
    • Tse HN, Raiteri L, Wong KY, et al. High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study. Chest 2013; 144: 106-118.
    • (2013) Chest , vol.144 , pp. 106-118
    • Tse, H.N.1    Raiteri, L.2    Wong, K.Y.3
  • 21
    • 0019183068 scopus 로고
    • Long-term oral acetylcysteine in chronic bronchitis. A double-blind controlled study
    • Babolini G, Blasi A, Comia G, et al. Long-term oral acetylcysteine in chronic bronchitis. A double-blind controlled study. Eur J Respir Dis Suppl 1980; 111: 93-108.
    • (1980) Eur J Respir Dis Suppl , vol.111 , pp. 93-108
    • Babolini, G.1    Blasi, A.2    Comia, G.3
  • 22
    • 0022414065 scopus 로고
    • Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee
    • McGavin CR, MacFarlane JT, Prescott RJ, et al. Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee. Thorax 1985; 40: 832-835.
    • (1985) Thorax , vol.40 , pp. 832-835
    • McGavin, C.R.1    Macfarlane, J.T.2    Prescott, R.J.3
  • 23
    • 0020615142 scopus 로고
    • Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: Report of a trial organized by the Swedish Society for Pulmonary Diseases
    • Boman G, Bäcker U, Larsson S, et al. Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases. Eur J Respir Dis 1983; 64: 405-415.
    • (1983) Eur J Respir Dis , vol.64 , pp. 405-415
    • Boman, G.1    Bäcker, U.2    Larsson, S.3
  • 24
    • 0032759974 scopus 로고    scopus 로고
    • N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD
    • Pela R, Calcagni AM, Subiaco S, et al. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration 1999; 66: 495-500.
    • (1999) Respiration , vol.66 , pp. 495-500
    • Pela, R.1    Calcagni, A.M.2    Subiaco, S.3
  • 25
    • 0023912569 scopus 로고
    • Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis
    • Rasmussen JB, Glennow C. Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis. Eur Respir J 1988; 1: 351-355.
    • (1988) Eur Respir J , vol.1 , pp. 351-355
    • Rasmussen, J.B.1    Glennow, C.2
  • 26
    • 60649103762 scopus 로고    scopus 로고
    • Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis
    • Schermer T, Chavannes N, Dekhuijzen R, et al. Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis. Respir Med 2009; 103: 542-551.
    • (2009) Respir Med , vol.103 , pp. 542-551
    • Schermer, T.1    Chavannes, N.2    Dekhuijzen, R.3
  • 27
    • 34548107307 scopus 로고    scopus 로고
    • Effect of oral N-acetylcysteine in COPD -a randomised controlled trial
    • Bachh AA, Shah NN, Bhargava R, et al. Effect of oral N-acetylcysteine in COPD -a randomised controlled trial. JK Practitioner 2007; 14: 12-16.
    • (2007) JK Practitioner , vol.14 , pp. 12-16
    • Bachh, A.A.1    Shah, N.N.2    Bhargava, R.3
  • 28
    • 0017111053 scopus 로고
    • A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis
    • Grassi C, Morandini GC. A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis. Eur J Clin Pharmacol 1976; 9: 393-396.
    • (1976) Eur J Clin Pharmacol , vol.9 , pp. 393-396
    • Grassi, C.1    Morandini, G.C.2
  • 29
    • 0037718518 scopus 로고    scopus 로고
    • N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease
    • Gerrits CM, Herings RM, Leufkens HG, et al. N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. Eur Respir J 2003; 21: 795-798.
    • (2003) Eur Respir J , vol.21 , pp. 795-798
    • Gerrits, C.M.1    Herings, R.M.2    Leufkens, H.G.3
  • 30
    • 70349694402 scopus 로고    scopus 로고
    • Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk
    • Guerra S, Sherrill DL, Venker C, et al. Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk. Thorax 2009; 64: 894-900.
    • (2009) Thorax , vol.64 , pp. 894-900
    • Guerra, S.1    Sherrill, D.L.2    Venker, C.3
  • 31
    • 0021261611 scopus 로고
    • Chronic bronchitis. Correlation of morphologic findings to sputum production and flow rates
    • Jamal K, Cooney TP, Fleetham JA, et al. Chronic bronchitis. Correlation of morphologic findings to sputum production and flow rates. Am Rev Respir Dis 1984; 129: 719-722.
    • (1984) Am Rev Respir Dis , vol.129 , pp. 719-722
    • Jamal, K.1    Cooney, T.P.2    Fleetham, J.A.3
  • 32
    • 38849185354 scopus 로고    scopus 로고
    • Definition, epidemiology and natural history of COPD
    • Viegi G, Pistelli F, Sherrill DL, et al. Definition, epidemiology and natural history of COPD. Eur Respir J 2007; 30: 993-1013.
    • (2007) Eur Respir J , vol.30 , pp. 993-1013
    • Viegi, G.1    Pistelli, F.2    Sherrill, D.L.3
  • 33
    • 84905676087 scopus 로고    scopus 로고
    • Defining phenotypes in COPD: An aid to personalized healthcare
    • Segreti A, Stirpe E, Rogliani P, et al. Defining phenotypes in COPD: an aid to personalized healthcare. Mol Diagn Ther 2014; 18: 381-388.
    • (2014) Mol Diagn Ther , vol.18 , pp. 381-388
    • Segreti, A.1    Stirpe, E.2    Rogliani, P.3
  • 34
    • 85047695734 scopus 로고    scopus 로고
    • Clinical phenotypes of COPD: Identification, definition and implications for guidelines
    • Miravitlles M, Calle M, Soler-Cataluña JJ. Clinical phenotypes of COPD: identification, definition and implications for guidelines. Arch Bronconeumol 2012; 48: 86-98.
    • (2012) Arch Bronconeumol , vol.48 , pp. 86-98
    • Miravitlles, M.1    Calle, M.2    Soler-Cataluña, J.J.3
  • 35
    • 84907224420 scopus 로고    scopus 로고
    • Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD
    • Tse HN, Raiteri L, Wong KY, et al. Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD. Chest 2014; 146: 611-623.
    • (2014) Chest , vol.146 , pp. 611-623
    • Tse, H.N.1    Raiteri, L.2    Wong, K.Y.3
  • 36
    • 84989360042 scopus 로고    scopus 로고
    • Executive summary: Prevention of acute exacerbation of COPD: American College of Chest Physicians and Canadian Thoracic Society guideline
    • Criner GJ, Bourbeau J, Diekemper RL, et al. Executive summary: prevention of acute exacerbation of COPD: American College of Chest Physicians and Canadian Thoracic Society guideline. Chest 2015; 147: 883-893.
    • (2015) Chest , vol.147 , pp. 883-893
    • Criner, G.J.1    Bourbeau, J.2    Diekemper, R.L.3
  • 37
    • 84891883913 scopus 로고    scopus 로고
    • Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits
    • Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther 2014; 141: 150-159.
    • (2014) Pharmacol Ther , vol.141 , pp. 150-159
    • Rushworth, G.F.1    Megson, I.L.2
  • 38
    • 33750484015 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review
    • Sadowska AM, Manuel-y-Keenoy B, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther 2007; 20: 9-22.
    • (2007) Pulm Pharmacol Ther , vol.20 , pp. 9-22
    • Sadowska, A.M.1    Manuel-Y-Keenoy, B.2    De Backer, W.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.