Lysosomal dysfunction caused by cellular accumulation of silica nanoparticles

Journal of Biological Chemistry

Volumn 291, Issue 27, 2016, Pages 14170-14184

  Schütz, Irene ^a   Lopez Hernandez, Tania ^a   Gao, Qi ^b   Puchkov, Dmytro ^a   JaBerlinbs, Sabrina ^a,c   Nordmeyer, Daniel ^b   Schmudde, Madlen ^b   Rühl, Eckart ^b   Graf, Christina M ^b   Haucke, Volker ^a,b  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; PHYSIOLOGY; PROTEINS; SILICA;

AGGREGATED PROTEIN; ENDOSOMAL RECYCLING; EPIDERMAL GROWTH FACTORS; NANOPARTICLE (NPS); PROTEIN DEGRADATION; PROTEIN TURNOVERS; SILICA NANOPARTICLES; SURFACE FUNCTIONALIZED SILICA NANOPARTICLES;

NANOPARTICLES;

CATHEPSIN B; CATHEPSIN L; CLATHRIN; DYNAMIN II; EPIDERMAL GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; SILICA NANOPARTICLE; NANOPARTICLE; SILICON DIOXIDE;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL PH; CELL VIABILITY; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HELA CELL LINE; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR TRANSPORT; LYSOSOME; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; METABOLISM;

ENDOCYTOSIS; HELA CELLS; HUMANS; LYSOSOMES; NANOPARTICLES; SILICON DIOXIDE;

EID: 84976630045     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.710947     Document Type: Article

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