Lysosomal iron liberation is responsible for the vulnerability of brain microglial cells to iron oxide nanoparticles: Comparison with neurons and astrocytes

Nanotoxicology

Volumn 10, Issue 3, 2016, Pages 332-342

  Petters, Charlotte ^a   Thiel, Karsten ^b   Dringen, Ralf ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b FRAUNHOFER INSTITUTE FOR MANUFACTURING TECHNOLOGY AND ADVANCED MATERIALS IFAM   (Germany)

Author keywords

Lysosomes; oxidative stress; protection; reactive oxygen species; toxicity

Indexed keywords

2,2' BIPYRIDINE; BAFILOMYCIN A1; IRON CHELATING AGENT; REACTIVE OXYGEN METABOLITE; SUCCIMER; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; MAGNETITE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN CELL; CELL DAMAGE; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE; INCUBATION TIME; INVESTIGATIVE PROCEDURES; IRON CHELATION; LYSOSOME; MICROGLIA; MICROGLIAL CELL CULTURE; MICROGLIAL TOXICITY; NONHUMAN; PH; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; TOXICITY; ANIMAL; BRAIN; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NERVE CELL;

2,2'-DIPYRIDYL; ANIMALS; ASTROCYTES; BRAIN; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MAGNETITE NANOPARTICLES; MICROGLIA; NEURONS; PRIMARY CELL CULTURE; RATS; REACTIVE OXYGEN SPECIES; SUCCIMER;

EID: 84959508264     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2015.1071445     Document Type: Article

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