Chemoprotective effect of N-acetylcysteine (NAC) on cellular oxidative damages and apoptosis induced by nano titanium dioxide under UVA irradiation

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 110-116

  Xue, Chengbin ^a   Liu, Wei ^a   Wu, Jianhong ^b   Yang, Xiangliang ^a   Xu, Huibi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Chemoprotective effect; HaCaT cells; N acetylcysteine; Nano titanium dioxide; UVA irradiation

Indexed keywords

ACETYLCYSTEINE; CYTOKERATIN 6; MALONALDEHYDE; MESSENGER RNA; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL LEVEL; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INCUBATION TIME; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; ULTRAVIOLET RADIATION;

ACETYLCYSTEINE; ANTIOXIDANTS; APOPTOSIS; CELL LINE; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; KERATIN-6; KERATINOCYTES; LIPID PEROXIDATION; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; METAL NANOPARTICLES; NITRIC OXIDE; OXIDANTS, PHOTOCHEMICAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TITANIUM; ULTRAVIOLET RAYS;

EID: 78650518772     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.09.014     Document Type: Article

References (39)

1. Angelo S., Ingrosso D., Perfetto B., Baroni A., Zappia M., Lobianco L.L., Tufano M.A., Galletti P. UVA irradiation induces l-isoaspartyl formation in melanoma cell proteins. Free Radical Biology and Medicine 2001, 31:1-9.
2. 2 particles. Cancer Research 1992, 52:2346-2348.
3. Carinci F., Volinia S., Pezzetti F., Francioso F., Tosi L., Piattelli A. Titanium-cell interaction: analysis of gene expression profiling. Journal of Biomedical Materials Research 2003, 66B:341-346.
4. Chang S.Q., Dai Y.D., Kang B., Han W., Mao L., Chen D. UV-enhanced cytotoxicity of thiol-capped CdTe quantum dots in human pancreatic carcinoma cells. Toxicology Letters 2009, 188:104-111.
5. Draper H.H., Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods in Enzymology 1990, 186:421-431.
6. Dunford R., Salinaro A., Cai L., Serpone N., Horikoshi S., Hidaka H., Knowland J. Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients. FEBS Letters 1997, 418:87-90.
7. 2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion. Toxicology Letter 2009, 191:109-117.
8. Gang, M.H., Young, S.R., Hyo, Yun, Y., Byeong, H.J., Yong, M.K., Jeong, H.S., Jae, H.L., 1999. Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-κB. Biochemical and Biophysical Research Communications 261, 917-922.
9. Grinberg L., Fibach E., Amer J., Atlas D. N-Acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radical Biology and Medicine 2005, 38:136-145.
10. Gurr J.R., Wang A.S., Chen C.H., Jan K.Y. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 2005, 213:66-73.
11. Hirakawa K., Mori M., Yoshida M., Oikawa S., Kawanishi S. Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide. Free Radical Research 2004, 38:439-447.
12. Kang J.L., Moon C., Lee H.S., Lee H.W., Park E.M., Kim H.S., Castranova V. Comparison of the biological activity between ultrafine and fine titanium dioxide particles in RAW 264.7 cells associated with oxidative stress. Journal of Toxicology and Environmental Health 2008, 71:478-485.
13. Liu S., Xu L., Zhang T., Ren G., Yang Z. Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells. Toxicology 2010, 267:172-177.
14. Long T.C., Tajuba J., Sama P., Saleh N., Swartz C., Parker J., Hester S., Lowry G.V., Veronesi B. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environmental Health Perspectives 2007, 115:1631-1637.
15. Ma L., Yamada S., Wirtz D., Coulombe P.A. A 'hot-spot' mutation alters the mechanical properties of keratin Wlament networks. Nature Cell Biology 2001, 3:503-506.
16. Moschou M., Kosmidi E.K., Kaloyianni M., Geronikaki A., Dabarakis N., Theophilidis G. In vitro assessment of the neurotoxic and neuroprotective effects of N-acetyl-l-cysteine (NAC) on the rat sciatic nerve fibers. Toxicology In Vitro 2008, 22:267-274.
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983, 65:55-63.
18. Nakagawa Y., Wakuri S., Sakamoto K., Tanaka N. The photogenotoxicity of titanium dioxide particles. Mutation Research 1997, 394:125-132.
19. Nel A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
20. Pagoria D., Geurtsen W. The effect of N-acetyl-l-cysteine and ascorbic acid on visible-light-irradiated camphorquinone/N,N-dimethyl-p-toluidine-induced oxidative stress in two immortalized cell lines. Biomaterials 2005, 26:6136-6142.
21. Park E.J., Yi J., Chung K.H., Ryu D.Y., Choi J., Park K. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicology Letter 2008, 180:222-229.
22. Rahman Q., Lohani M., Dopp E., Pemsel H., Jonas L., Weiss D.G., Schiffmann D. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environmental Health Perspectives 2002, 110:797-800.
23. Rehn B., Seiler F., Rehn S., Bruch J., Maier M. Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: untreated and surface treated. Toxicology and Applied Pharmacology 2003, 189:84-95.
24. Sano T., Kume T., Fujimura T., Kawada H., Higuchi K., Iwamura M., Hotta M., Kitahara T., Takema Y. Long-term alteration in the expression of keratins 6 and 16 in the epidermis of mice after chronic UVB exposure. Archives of Dermatological Research 2009, 301:227-237.
25. Smith S.S., Reyes J.R., Arbon K.S., Harvey W.A., Hunt L.M., Heggland S.J. Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast like cell line, Saos-2. Toxicology In Vitro 2009, 23:61-66.
26. Stanislawski L., Soheili M.E., Perianin A., Goldberg M. Dental restorative biomaterials induce glutathione depletion in cultured human gingival fibroblast: protective effect of N-acetyl cysteine. Journal of Biomedical Materials Research 2000, 51:469-474.
27. Stanislawski L., Lefeuvre M., Bourd K., Soheili M.E., Goldberg M., Perianin A. TEGDMA induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species. Journal of Biomedical Materials Research 2003, 66A:476-482.
28. 2-UVA treatment. Toxicology In Vitro 2002, 16:629-635.
29. Wamer W.G., Yin J.J., Wei R.R. Oxidative damage to nucleic acids photosensitized by titanium dioxide. Free Radical Biology and Medicine 1997, 23:851-858.
30. 2 particles in cultured human lymphoblastoid cells. Mutation Research 2007, 628:99-106.
31. Weigand, M.A., Plachky, J., Thies, J.C., Spies, M.D., Otto, G., Martin, E., Bardenheuer, H.J., 2001. N-Acetylcysteine attenuates the increase in a-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation 72, 694-698.
32. Winter K., Pagoria D., Geurtsen W. The effect of antioxidants on oxidative DNA damage induced by visible-light-irradiated camphorquinone/N,N-dimethyl-p-toluidine. Biomaterials 2005, 26:5321-5329.
33. Wong P., Coulombe P.A. Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair. Journal of Cell Biology 2003, 163:327-337.
34. 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicology Letters 2009, 191:1-8.
35. Xiong F.L., Sun X.H., Gan L., Yang X.L., Xu H.B. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. European Journal of Pharmacology 2006, 529:1-7.
36. Xue C.B., Wu J.H., Liu W., Lan F.L., Yang X.L., Zeng F.D., Xu H.B. Nano titanium dioxide induces the generation of ROS and potential damage in HaCaT Cells under UVA irradiation. Journal of Nanoscience and Nanotechnology 2010, 10:5800-5807.
37. Young F.M., Phungtamdet W., Sanderson B.J.S. Modification of MTT assay conditions to examine the cytotoxic effects of amitraz on the human lymphoblastoid cell line, WIL2NS. Toxicology In Vitro 2005, 19:1051-1059.
38. 2 nanoparticles on Ls-174-t human colon carcinoma cells. World Journal of Gastroenterology 2004, 10:3191-3193.
39. Zhang L., Jiang Y., Ding Y., Povey M., York D. Investigation into the antibacterial behaviour of suspensions of ZnO Nanoparticles (ZnO nanofluids). Journal of Nanoparticle Research 2007, 9:479-489.