Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways

Toxicology in Vitro

Volumn 27, Issue 3, 2013, Pages 1082-1088

  Cheng, Guilin ^a   Guo, Wei ^b   Han, Lu ^a   Chen, Erlei ^c   Kong, Lingfang ^c   Wang, Lili ^d   Ai, Wenchao ^a   Song, Naining ^a   Li, Haishan ^a   Chen, Huiming ^a  

^a CHINESE ACADEMY OF INSPECTION AND QUARANTINE   (China)

^b BEIJING UNIVERSITY OF AGRICULTURE   (China)

^c SOUTH CHINA NORMAL UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

CeO2 nanoparticles; Cytotoxicity; MAPKs; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; CATALASE; CERIUM OXIDE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER TOXICITY; OXIDATIVE STRESS;

ACETYLCYSTEINE; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CATALASE; CELL LINE, TUMOR; CELL SURVIVAL; CERIUM; GLUTATHIONE PEROXIDASE; HUMANS; MALONDIALDEHYDE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NANOPARTICLES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84874721222     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.02.005     Document Type: Article

References (32)

1. Chen D. Design, synthesis and properties of highly functional nanostructured photocatalysts. Recent Pat. Nanotechnol. 2008, 2:183-189.
2. Riehemann K., Schneider S.W., Luger T.A., Godin B., Ferrari M., Fuchs H. Nanomedicine-challenge and perspectives. Angew. Chem. Int. Ed. Engl. 2009, 48:872-897.
3. Sun D., Meng T.T., Loong T.H., Hwa T.J. Removal of natural organic matter from water using a nano-structured photocatalyst coupled with filtration membrane. Water Sci. Technol. 2004, 49:103-110.
4. Park E.J., Yi J., Chung K.H., Ryu D.Y., Choi J., Park K. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol. Lett. 2008, 180:222-229.
5. Frohlich E., Roblegg E. Models for oral uptake of nanoparticles in consumer products. Toxicology 2012, 291:10-17.
6. 2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B. Toxicol. Lett. 2009, 187:77-83.
7. 2 and ZnO nanoparticles to human lung cells. J. Nanosci. Nanotechnol. 2010, 10:3453-3458.
8. 2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism. Environ. Sci. Technol. 2006, 40:6151-6156.
9. Gojova A., Lee J.T., Jung H.S., Guo B., Barakat A.I., Kennedy I.M. Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells. Inhal. Toxicol. 2009, 21(Suppl 1):123-130.
10. Bu Q., Yan G., Deng P., Peng F., Lin H., Xu Y., Cao Z., Zhou T., Xue A., Wang Y., Cen X., Zhao Y.L. NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology 2010, 21:125105.
11. Srinivas A., Rao P.J., Selvam G., Murthy P.B., Reddy P.N. Acute inhalation toxicity of cerium oxide nanoparticles in rats. Toxicol. Lett. 2011, 205:105-115.
12. Takenaka S., Karg E., Roth C., Schulz H., Ziesenis A., Heinzmann U., Schramel P., Heyder J. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ. Health Perspect. 2001, 109(Suppl 4):547-551.
13. Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 2006, 114:165-172.
14. Oberdorster G., Oberdorster E., Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005, 113:823-839.
15. Arora S., Jain J., Rajwade J.M., Paknikar K.M. Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells. Toxicol. Appl. Pharmacol. 2009, 236:310-318.
16. Xia T., Kovochich M., Liong M., Madler L., Gilbert B., Shi H., Yeh J.I., Zink J.I., Nel A.E. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008, 2:2121-2134.
17. Srinivas A., Jaganmohan R.P., Selvam G., Goparaju A., Balakrishna M.P., Neelakanta R.P. Oxidative stress and inflammatory responses of rat following acute inhalation exposure to iron oxide nanoparticles 2012, Hum. Exp. Toxicol.
18. Saquib Q., Al-Khedhairy A.A., Siddiqui M.A., Abou-Tarboush F.M., Azam A., Musarrat J. Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells. Toxicol. In Vitro 2012, 26:351-361.
19. Ahmad A., Rasheed N., Banu N., Palit G. Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress 2010, 13:355-364.
20. Belozerskaia T.A., Gessler N.N. Reactive oxygen species and the strategy of the antioxidant defense in fungi: a review. Prikl. Biokhim. Mikrobiol. 2007, 43:565-575.
21. Naziroglu M., Akkus S., Soyupek F., Yalman K., Celik O., Eris S., Uslusoy G.A. Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: a controlled clinical pilot study. Stress 2010, 13:498-505.
22. Wan R., Mo Y., Feng L., Chien S., Tollerud D.J., Zhang Q. DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM dagger. Chem. Res. Toxicol. 2012, 25:1402-1411.
23. Smith S.S., Reyes J.R., Arbon K.S., Harvey W.A., Hunt L.M., Heggland S.J. Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast-like cell line, Saos-2. Toxicol. In Vitro 2009, 23:60-66.
24. Wang J., Sun P., Bao Y., Liu J., An L. Cytotoxicity of single-walled carbon nanotubes on PC12 cells. Toxicol. In Vitro 2011, 25:242-250.
25. Park S.K., Dahmer M.K., Quasney M.W. MAPK and JAK-STAT signaling pathways are involved in the oxidative stress - induced decrease in expression of surfactant protein genes. Cell. Physiol. Biochem. 2012, 30:334-346.
26. Yamada T., Egashira N., Bando A., Nishime Y., Tonogai Y., Imuta M., Yano T., Oishi R. Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury. Free Radic. Biol. Med. 2012, 52:1285-1293.
27. Muthusamy V., Piva T.J. The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways. Arch. Dermatol. Res. 2010, 302:5-17.
28. Peter A.T., Dhanasekaran N. Apoptosis of granulosa cells: a review on the role of MAPK-signalling modules. Reprod. Domest. Anim. 2003, 38:209-213.
29. Jorge A.A., Malaquias A.C., Arnhold I.J., Mendonca B.B. Noonan syndrome and related disorders: a review of clinical features and mutations in genes of the RAS/MAPK pathway. Horm. Res. 2009, 71:185-193.
30. Yi C., Liu D., Fong C.C., Zhang J., Yang M. Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway. ACS Nano 2010, 4:6439-6448.
31. Eom H.J., Choi J. P38 MAPK activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells. Environ. Sci. Technol. 2010, 44:8337-8342.
32. Lim D., Roh J.Y., Eom H.J., Choi J.Y., Hyun J., Choi J. Oxidative stress-related PMK-1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans. Environ. Toxicol. Chem. 2012, 31:585-592.