Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 5131-5141

  Duan, Junchao ^a   Yu, Yongbo ^a   Yu, Yang ^a   Li, Yang ^a   Wang, Ji ^a   Geng, Weijia ^a   Jiang, Lizhen ^a   Li, Qiuling ^a   Zhou, Xianqing ^a   Sun, Zhiwei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Endothelial dysfunction; Inflammation; Nitric oxide; Silica nanoparticles

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; NANOPARTICLE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SILICON DIOXIDE; TUMOR NECROSIS FACTOR ALPHA; TARGET OF RAPAMYCIN KINASE;

ARTICLE; AUTOPHAGY; CELL CULTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HYDRODYNAMICS; INFLAMMATION; M PHASE CELL CYCLE CHECKPOINT; PARTICLE SIZE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; UMBILICAL VEIN ENDOTHELIAL CELL;

AUTOPHAGY; CELL LINE; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NANOPARTICLES; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SILICON DIOXIDE; TOR SERINE-THREONINE KINASES;

EID: 84908518539     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S71074     Document Type: Article

References (42)

1. Parveen S, Misra R, Sahoo SK. Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine. 2012; 8(2):147-166.
2. Bitar A, Ahmad NM, Fessi H, Elaissari A. Silica-based nanoparticles for biomedical applications. Drug Discov Today. 2012;17(19-20): 1147-1154.
3. Halas NJ. Nanoscience under glass: the versatile chemistry of silica nanostructures. ACS Nano. 2008;2(2):179-183.
4. United States Government Accountability Office. United States Government Accountability Office report on nanotechnology: nanomaterials are widely used in commerce, but EPA faces challenges in regulating risk. Int J Occup Environ Health. 2010;16(4):525-539.
5. Fako VE, Furgeson DY. Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity. Adv Drug Deliv Rev. 2009;61(6):478-486.
6. Stern ST, Adiseshaiah PP, Crist RM. Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol. 2012;9:20.
7. Teng RJ, Du J, Welak S, et al. Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012;302(7):L651-L663.
8. Zabirnyk O, Yezhelyev M, Seleverstov O. Nanoparticles as a novel class of autophagy activators. Autophagy. 2007;3(3):278-281.
9. Suri SS, Fenniri H, Singh B. Nanotechnology-based drug delivery systems. J Occup Med Toxicol. 2007;2:16.
10. Liu X, Sun J. Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kappaB pathways. Biomaterials. 2010;31(32):8198-8209.
11. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323(1):22-27.
12. Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol. 2004;15(8):1983-1992.
13. Alom-Ruiz SP, Anilkumar N, Shah AM. Reactive oxygen species and endothelial activation. Antioxid Redox Signal. 2008;10(6):1089-1100.
14. Duan J, Yu Y, Shi H, et al. Toxic effects of silica nanoparticles on zebrafish embryos and larvae. PLoS One. 2013;8(9):e74606.
15. Duan J, Yu Y, Li Y, Yu Y, Sun Z. Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model. Biomaterials. 2013;34(23):5853-5862.
16. Xu J, Sun L, Li J, Liang J, Zhang H, Yang W. FITC and Ru(phen)32+ co-doped silica particles as visualized ratiometric pH indicator. Nanoscale Res Lett. 2011;6(1):561.
17. Duan J, Yu Y, Li Y, et al. Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint. PLoS One. 2013;8(4):e62087.
18. Yu Y, Duan J, Yu Y, et al. Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species. J Hazard Mater. 2014;270:176-186.
19. Smith AM, Duan H, Mohs AM, Nie S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev. 2008;60(11):1226-1240.
20. Sun L, Li Y, Liu X, et al. Cytotoxicity and mitochondrial damage caused by silica nanoparticles. Toxicol In Vitro. 2011;25(8):1619-1629.
21. Afeseh Ngwa H, Kanthasamy A, Gu Y, Fang N, Anantharam V, Kanthasamy AG. Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells. Toxicol Appl Pharmacol. 2011;256(3):227-240.
22. Wu YN, Yang LX, Shi XY, et al. The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondriamediated autophagy. Biomaterials. 2011;32(20):4565-4573.
23. Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagyinflammation- cell death axis in organismal aging. Science. 2011; 333(6046):1109-1112.
24. Dromparis P, Michelakis ED. Mitochondria in vascular health and disease. Annu Rev Physiol. 2013;75:95-126.
25. Blouin A, Bolender RP, Weibel ER. Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study. J Cell Biol. 1977;72(2): 441-455.
26. Zhao Y, Howe JL, Yu Z, et al. Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes. Small. 2013;9(3): 387-392.
27. Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy. 2007;3(6):542-545.
28. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8(4):445-544.
29. de Fátima A, Zambuzzi WF, Modolo LV, et al. Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy. Chem Biol Interact. 2008;176(2-3):143-150.
30. Walshe TE, Connell P, Cryan L, Ferguson G, O’Brien C, Cahill PA. The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation. Cardiovasc Res. 2011;89(3):661-670.
31. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87(1):315-424.
32. Corbalan JJ, Medina C, Jacoby A, Malinski T, Radomski MW. Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects. Int J Nanomedicine. 2011;6:2821-2835.
33. Sarkar S, Korolchuk VI, Renna M, et al. Complex inhibitory effects of nitric oxide on autophagy. Mol Cell. 2011;43(1):19-32.
34. Ramage L, Guy K. Expression of C-reactive protein and heat-shock protein-70 in the lung epithelial cell line A549, in response to PM10 exposure. Inhal Toxicol. 2004;16(6-7):447-452.
35. Yuan XM, Li W. Iron involvement in multiple signaling pathways of atherosclerosis: a revisited hypothesis. Curr Med Chem. 2008;15(21): 2157-2172.
36. Fibrinogen Studies Collaboration; Kaptoge S, White IR, Thompson SG, et al. Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. Am J Epidemiol. 2007;166(8):867-879.
37. Schanen BC, Karakoti AS, Seal S, Drake DR 3rd, Warren WL, Self WT. Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct. ACS Nano. 2009;3(9): 2523-2532.
38. Oesterling E, Chopra N, Gavalas V, et al. Alumina nanoparticles induce expression of endothelial cell adhesion molecules. Toxicol Lett. 2008;178(3):160-166.
39. Harris J. Autophagy and cytokines. Cytokine. 2011;56(2):140-144.
40. Pyo JO, Nah J, Jung YK. Molecules and their functions in autophagy. Exp Mol Med. 2012;44(2):73-80.
41. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669-676.
42. Wu CC, Schwartzman ML. The role of 20-HETE in androgen-mediated hypertension. Prostaglandins Other Lipid Mediat. 2011;96(1-4): 45-53.