Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Duan, Junchao ^a   Yu, Yongbo ^a   Yu, Yang ^a   Li, Yang ^a   Huang, Peili ^a   Zhou, Xianqing ^a   Peng, Shuangqing ^b   Sun, Zhiwei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Angiogensis; Autophagy; Crosstalk; Endothelium; Nanotoxicology; Silica nanoparticles; VEGFR2

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; F ACTIN; INTERCELLULAR ADHESION MOLECULE 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NANOPARTICLE; PHOSPHATIDYLINOSITOL 3 KINASE; SILICA NANOPARTICLE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN RECEPTOR 2; ACTIN; CELL ADHESION MOLECULE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; SILICON DIOXIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CARDIOTOXICITY; CELL MEMBRANE DEPOLARIZATION; CELL METABOLISM; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PERICYTE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CORONARY BLOOD VESSEL; CYTOSKELETON; DOSE RESPONSE; DRUG EFFECTS; HOMEOSTASIS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PARTICLE SIZE; ULTRASTRUCTURE; UMBILICAL VEIN ENDOTHELIAL CELL;

ACTINS; ANIMALS; AUTOPHAGY; CELL ADHESION MOLECULES; CORONARY VESSELS; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FEMALE; HOMEOSTASIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; MALE; MICE, INBRED ICR; MICROTUBULE-ASSOCIATED PROTEINS; NANOPARTICLES; NEOVASCULARIZATION, PHYSIOLOGIC; PARTICLE SIZE; PERICYTES; SIGNAL TRANSDUCTION; SILICON DIOXIDE;

EID: 84908012743     PISSN: 17438977     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0050-8     Document Type: Article

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