Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos

Nanotoxicology

Volumn 10, Issue 5, 2016, Pages 575-585

  Duan, Junchao ^a   Yu, Yang ^a   Li, Yang ^a   Li, Yanbo ^a   Liu, Hongcui ^b   Jing, Li ^a   Yang, Man ^a   Wang, Ji ^a   Li, Chunqi ^b   Sun, Zhiwei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Transfarland   (China)

Author keywords

Cardiac dysfunction; cardiac muscle contraction; inflammation; silica nanoparticles; zebrafish

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BIOLOGICAL MARKER; CALCIUM; CALCIUM CHANNEL; DIANISIDINE; SILICA NANOPARTICLE; TNNT2 PROTEIN; TROPONIN C; TROPONIN T; UNCLASSIFIED DRUG; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATP1A3B GENE; ATP1B2B GENE; ATP2A1L GENE; BIOINFORMATICS; BRADYCARDIA; CACNA1AB GENE; CACNA1DA GENE; CALCIUM SIGNALING; CARDIOTOXICITY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ERYTHROCYTE; EXPOSURE; GENE; GENE EXPRESSION; HEART CONTRACTION; HEART EDEMA; HEART OUTPUT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; MICROARRAY ANALYSIS; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; TNNC1A GENE; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; BLOOD; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; HEART; HEART FUNCTION TEST; IMMUNOLOGY; NONMAMMALIAN EMBRYO;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, NONMAMMALIAN; HEART; HEART FUNCTION TESTS; INFLAMMATION; MYOCARDIAL CONTRACTION; NANOPARTICLES; NEUTROPHILS; OXIDATIVE STRESS; SILICON DIOXIDE; ZEBRAFISH;

EID: 84946593890     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2015.1102981     Document Type: Article

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