-
1
-
-
84928489717
-
+ T cell formation
-
+ T cell formation. Elife, 3, 2014, 0000.
-
(2014)
Elife
, vol.3
, pp. 0000
-
-
Puleston, D.J.1
-
2
-
-
84937517237
-
Autophagy controls acquisition of aging features in macrophages
-
2 Stranks, A.J., et al. Autophagy controls acquisition of aging features in macrophages. J. Innate Immun. 7 (2015), 375–391.
-
(2015)
J. Innate Immun.
, vol.7
, pp. 375-391
-
-
Stranks, A.J.1
-
3
-
-
84902954600
-
Essential role for autophagy in the maintenance of immunological memory against influenza infection
-
3 Chen, M., et al. Essential role for autophagy in the maintenance of immunological memory against influenza infection. Nat. Med. 20 (2014), 503–510.
-
(2014)
Nat. Med.
, vol.20
, pp. 503-510
-
-
Chen, M.1
-
4
-
-
80052303130
-
Autophagy and aging
-
4 Rubinsztein, D.C., et al. Autophagy and aging. Cell 146 (2011), 682–695.
-
(2011)
Cell
, vol.146
, pp. 682-695
-
-
Rubinsztein, D.C.1
-
5
-
-
0026023219
-
Hydrogen peroxide release by mitochondria increases during aging
-
5 Sohal, R.S., Sohal, B.H., Hydrogen peroxide release by mitochondria increases during aging. Mech. Ageing Dev. 57 (1991), 187–202.
-
(1991)
Mech. Ageing Dev.
, vol.57
, pp. 187-202
-
-
Sohal, R.S.1
Sohal, B.H.2
-
6
-
-
78650142376
-
Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease
-
6 Grimm, S., et al. Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic. Res. 45 (2011), 73–88.
-
(2011)
Free Radic. Res.
, vol.45
, pp. 73-88
-
-
Grimm, S.1
-
7
-
-
84878327461
-
Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues
-
7 Nie, B., et al. Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues. Oxid. Med. Cell Longev., 2013, 2013, 303181.
-
(2013)
Oxid. Med. Cell Longev.
, vol.2013
, pp. 303181
-
-
Nie, B.1
-
8
-
-
34250811414
-
The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains
-
8 Zhang, Y., et al. The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains. Autophagy 3 (2007), 337–346.
-
(2007)
Autophagy
, vol.3
, pp. 337-346
-
-
Zhang, Y.1
-
9
-
-
84905965017
-
Elimination of damaged mitochondria through mitophagy reduces mitochondrial oxidative stress and increases tolerance to trichothecenes
-
9 Bin-Umer, M.A., et al. Elimination of damaged mitochondria through mitophagy reduces mitochondrial oxidative stress and increases tolerance to trichothecenes. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 11798–11803.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 11798-11803
-
-
Bin-Umer, M.A.1
-
10
-
-
77956987110
-
2 and superoxide dismutase activity
-
2 and superoxide dismutase activity. Proc. Natl. Acad. Sci. U.S.A. 107 (2010), 15123–15128.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 15123-15128
-
-
Mesquita, A.1
-
11
-
-
61449184625
-
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
-
11 Van Raamsdonk, J.M., Hekimi, S., Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet., 5, 2009, e1000361.
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000361
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
12
-
-
78650455712
-
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
-
12 Yang, W., Hekimi, S., A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol., 8, 2010, e1000556.
-
(2010)
PLoS Biol.
, vol.8
, pp. e1000556
-
-
Yang, W.1
Hekimi, S.2
-
13
-
-
78650890352
-
Regulation of autophagy by ROS: physiology and pathology
-
13 Scherz-Shouval, R., Elazar, Z., Regulation of autophagy by ROS: physiology and pathology. Trends Biochem. Sci. 36 (2011), 30–38.
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 30-38
-
-
Scherz-Shouval, R.1
Elazar, Z.2
-
14
-
-
0002235236
-
On the nature of the aging process
-
14 Szilard, L., On the nature of the aging process. Proc. Natl. Acad. Sci. U.S.A. 45 (1959), 30–45.
-
(1959)
Proc. Natl. Acad. Sci. U.S.A.
, vol.45
, pp. 30-45
-
-
Szilard, L.1
-
15
-
-
41649091432
-
Bulky DNA lesions induced by reactive oxygen species
-
15 Wang, Y., Bulky DNA lesions induced by reactive oxygen species. Chem. Res. Toxicol. 21 (2008), 276–281.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 276-281
-
-
Wang, Y.1
-
16
-
-
84861000048
-
Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of alpha-lipoic acid and N-acetylcysteine
-
16 Ponte, F., et al. Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of alpha-lipoic acid and N-acetylcysteine. Orphanet J. Rare Dis., 7, 2012, 28.
-
(2012)
Orphanet J. Rare Dis.
, vol.7
, pp. 28
-
-
Ponte, F.1
-
17
-
-
84859352385
-
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
-
17 Hewitt, G., et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat. Commun., 3, 2012, 708.
-
(2012)
Nat. Commun.
, vol.3
, pp. 708
-
-
Hewitt, G.1
-
18
-
-
84955106488
-
Role of carbonyl modifications on aging-associated protein aggregation
-
18 Tanase, M., et al. Role of carbonyl modifications on aging-associated protein aggregation. Sci. Rep., 6, 2016, 19311.
-
(2016)
Sci. Rep.
, vol.6
, pp. 19311
-
-
Tanase, M.1
-
19
-
-
84930746830
-
The biology of proteostasis in aging and disease
-
19 Labbadia, J., Morimoto, R.I., The biology of proteostasis in aging and disease. Annu. Rev. Biochem. 84 (2015), 435–464.
-
(2015)
Annu. Rev. Biochem.
, vol.84
, pp. 435-464
-
-
Labbadia, J.1
Morimoto, R.I.2
-
20
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
20 Franceschi, C., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908 (2000), 244–254.
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
-
21
-
-
33947134377
-
Autophagy-dependent viral recognition by plasmacytoid dendritic cells
-
21 Lee, H.K., et al. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315 (2007), 1398–1401.
-
(2007)
Science
, vol.315
, pp. 1398-1401
-
-
Lee, H.K.1
-
22
-
-
84943789693
-
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation
-
22 Weindel, C.G., et al. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy 11 (2015), 1010–1024.
-
(2015)
Autophagy
, vol.11
, pp. 1010-1024
-
-
Weindel, C.G.1
-
23
-
-
82455210868
-
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta
-
23 Dupont, N., et al. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J. 30 (2011), 4701–4711.
-
(2011)
EMBO J.
, vol.30
, pp. 4701-4711
-
-
Dupont, N.1
-
24
-
-
84857195479
-
Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
-
24 Shi, C.S., et al. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 13 (2012), 255–263.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 255-263
-
-
Shi, C.S.1
-
25
-
-
84936985489
-
Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress
-
25 Shi, H., et al. Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress. Biochem. Biophys. Res. 463 (2015), 1071–1076.
-
(2015)
Biochem. Biophys. Res.
, vol.463
, pp. 1071-1076
-
-
Shi, H.1
-
26
-
-
84929630436
-
Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency
-
26 Abdel Fattah, E., et al. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency. J. Immunol. 194 (2015), 5407–5416.
-
(2015)
J. Immunol.
, vol.194
, pp. 5407-5416
-
-
Abdel Fattah, E.1
-
27
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
27 Nakahira, K., et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12 (2011), 222–230.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
28
-
-
84947249538
-
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
-
28 Gustot, A., et al. Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease. Biochem. J. 471 (2015), 323–333.
-
(2015)
Biochem. J.
, vol.471
, pp. 323-333
-
-
Gustot, A.1
-
29
-
-
84902297367
-
Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
-
29 Zhu, Y., et al. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr. Opin. Clin. Nutr. Metab. Care. 17 (2014), 324–328.
-
(2014)
Curr. Opin. Clin. Nutr. Metab. Care.
, vol.17
, pp. 324-328
-
-
Zhu, Y.1
-
30
-
-
84888320636
-
Age-dependent dysregulation of innate immunity
-
30 Shaw, A.C., et al. Age-dependent dysregulation of innate immunity. Nat. Rev. Immunol. 13 (2013), 875–887.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 875-887
-
-
Shaw, A.C.1
-
31
-
-
83755178932
-
Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
-
31 Lumeng, C.N., et al. Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J. Immunol. 187 (2011), 6208–6216.
-
(2011)
J. Immunol.
, vol.187
, pp. 6208-6216
-
-
Lumeng, C.N.1
-
32
-
-
84943242081
-
Differential gene expression profiles reflecting macrophage polarization in aging and periodontitis gingival tissues
-
32 Gonzalez, O.A., et al. Differential gene expression profiles reflecting macrophage polarization in aging and periodontitis gingival tissues. Immunol. Invest. 44 (2015), 643–664.
-
(2015)
Immunol. Invest.
, vol.44
, pp. 643-664
-
-
Gonzalez, O.A.1
-
33
-
-
84988945057
-
Age-dependent susceptibility to pulmonary fibrosis is associated with NLRP3 inflammasome activation
-
Published online March 2, 2016
-
33 Stout-Delgado, H.W., et al. Age-dependent susceptibility to pulmonary fibrosis is associated with NLRP3 inflammasome activation. Am. J. Respir. Cell Mol. Biol., 2016, 10.1165/rcmb.2015-0222OC Published online March 2, 2016.
-
(2016)
Am. J. Respir. Cell Mol. Biol.
-
-
Stout-Delgado, H.W.1
-
34
-
-
0036838909
-
Cutting edge: impaired Toll-like receptor expression and function in aging
-
34 Renshaw, M., et al. Cutting edge: impaired Toll-like receptor expression and function in aging. J. Immunol. 169 (2002), 4697–4701.
-
(2002)
J. Immunol.
, vol.169
, pp. 4697-4701
-
-
Renshaw, M.1
-
35
-
-
78649391849
-
Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis
-
35 Shaik-Dasthagirisaheb, Y.B., et al. Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis. Immun. Ageing., 7, 2010, 15.
-
(2010)
Immun. Ageing.
, vol.7
, pp. 15
-
-
Shaik-Dasthagirisaheb, Y.B.1
-
36
-
-
0036696554
-
Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age
-
36 Donnini, A., et al. Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age. Exp. Gerontol. 37 (2002), 1097–1112.
-
(2002)
Exp. Gerontol.
, vol.37
, pp. 1097-1112
-
-
Donnini, A.1
-
37
-
-
84861049969
-
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions
-
37 Jacquel, A., et al. Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions. Blood 119 (2012), 4527–4531.
-
(2012)
Blood
, vol.119
, pp. 4527-4531
-
-
Jacquel, A.1
-
38
-
-
84943791681
-
Macrophage autophagy protects against liver fibrosis in mice
-
38 Lodder, J., et al. Macrophage autophagy protects against liver fibrosis in mice. Autophagy 11 (2015), 1280–1292.
-
(2015)
Autophagy
, vol.11
, pp. 1280-1292
-
-
Lodder, J.1
-
39
-
-
84927641793
-
Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization
-
39 Liu, K., et al. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy 11 (2015), 271–284.
-
(2015)
Autophagy
, vol.11
, pp. 271-284
-
-
Liu, K.1
-
40
-
-
79955758952
-
+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells
-
+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells. Mech. Ageing Dev. 132 (2011), 187–194.
-
(2011)
Mech. Ageing Dev.
, vol.132
, pp. 187-194
-
-
Pereira, L.F.1
-
41
-
-
84861470332
-
Enumeration of human peripheral blood dendritic cells throughout the life
-
41 Orsini, G., et al. Enumeration of human peripheral blood dendritic cells throughout the life. Int. Immunol. 24 (2012), 347–356.
-
(2012)
Int. Immunol.
, vol.24
, pp. 347-356
-
-
Orsini, G.1
-
42
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
42 Cooney, R., et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16 (2010), 90–97.
-
(2010)
Nat. Med.
, vol.16
, pp. 90-97
-
-
Cooney, R.1
-
43
-
-
84954455174
-
Signaling through NOD-2 and TLR-4 bolsters the T cell priming capability of dendritic cells by inducing autophagy
-
43 Khan, N., et al. Signaling through NOD-2 and TLR-4 bolsters the T cell priming capability of dendritic cells by inducing autophagy. Sci. Rep., 6, 2016, 19084.
-
(2016)
Sci. Rep.
, vol.6
, pp. 19084
-
-
Khan, N.1
-
44
-
-
84943804411
-
Differential use of autophagy by primary dendritic cells specialized in cross-presentation
-
44 Mintern, J.D., et al. Differential use of autophagy by primary dendritic cells specialized in cross-presentation. Autophagy 11 (2015), 906–917.
-
(2015)
Autophagy
, vol.11
, pp. 906-917
-
-
Mintern, J.D.1
-
45
-
-
58149177781
-
Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation
-
45 Stout-Delgado, H.W., et al. Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J. Immunol. 181 (2008), 6747–6756.
-
(2008)
J. Immunol.
, vol.181
, pp. 6747-6756
-
-
Stout-Delgado, H.W.1
-
46
-
-
0028009618
-
Aging and marrow neutrophil reserves
-
46 Chatta, G.S., et al. Aging and marrow neutrophil reserves. J. Am. Geriatr. Soc. 42 (1994), 77–81.
-
(1994)
J. Am. Geriatr. Soc.
, vol.42
, pp. 77-81
-
-
Chatta, G.S.1
-
47
-
-
0033958830
-
Effect of age on human neutrophil function
-
47 Wenisch, C., et al. Effect of age on human neutrophil function. J. Leukoc. Biol. 67 (2000), 40–45.
-
(2000)
J. Leukoc. Biol.
, vol.67
, pp. 40-45
-
-
Wenisch, C.1
-
48
-
-
84942524791
-
Neutrophil ageing is regulated by the microbiome
-
48 Zhang, D., et al. Neutrophil ageing is regulated by the microbiome. Nature 525 (2015), 528–532.
-
(2015)
Nature
, vol.525
, pp. 528-532
-
-
Zhang, D.1
-
49
-
-
71749111987
-
Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection
-
49 Stout-Delgado, H.W., et al. Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe. 6 (2009), 446–456.
-
(2009)
Cell Host Microbe.
, vol.6
, pp. 446-456
-
-
Stout-Delgado, H.W.1
-
50
-
-
84873555175
-
Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age
-
50 Brubaker, A.L., et al. Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J. Immunol. 190 (2013), 1746–1757.
-
(2013)
J. Immunol.
, vol.190
, pp. 1746-1757
-
-
Brubaker, A.L.1
-
51
-
-
84864378864
-
Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus
-
51 Tseng, C.W., et al. Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus. PloS ONE, 7, 2012, e41454.
-
(2012)
PloS ONE
, vol.7
, pp. e41454
-
-
Tseng, C.W.1
-
52
-
-
0021027518
-
Age-related decline in lysosomal enzyme release from polymorphonuclear leukocytes after N-formyl-methionyl-leucyl-phenylalanine stimulation
-
52 Suzuki, K., et al. Age-related decline in lysosomal enzyme release from polymorphonuclear leukocytes after N-formyl-methionyl-leucyl-phenylalanine stimulation. Exp. Hematol. 11 (1983), 1005–1013.
-
(1983)
Exp. Hematol.
, vol.11
, pp. 1005-1013
-
-
Suzuki, K.1
-
53
-
-
77951735182
-
Regulation of the autophagic machinery in human neutrophils
-
53 Mitroulis, I., et al. Regulation of the autophagic machinery in human neutrophils. Eur. J. Immunol. 40 (2010), 1461–1472.
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 1461-1472
-
-
Mitroulis, I.1
-
54
-
-
84942827936
-
Autophagy is required for neutrophil-mediated inflammation
-
54 Bhattacharya, A., et al. Autophagy is required for neutrophil-mediated inflammation. Cell Rep. 12 (2015), 1731–1739.
-
(2015)
Cell Rep.
, vol.12
, pp. 1731-1739
-
-
Bhattacharya, A.1
-
55
-
-
84934762695
-
Enhancement of neutrophil autophagy by an IVIG preparation against multidrug-resistant bacteria as well as drug-sensitive strains
-
55 Itoh, H., et al. Enhancement of neutrophil autophagy by an IVIG preparation against multidrug-resistant bacteria as well as drug-sensitive strains. J. Leukoc. Biol. 98 (2015), 107–117.
-
(2015)
J. Leukoc. Biol.
, vol.98
, pp. 107-117
-
-
Itoh, H.1
-
56
-
-
84866554641
-
Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis
-
56 Kambas, K., et al. Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS ONE, 7, 2012, e45427.
-
(2012)
PLoS ONE
, vol.7
, pp. e45427
-
-
Kambas, K.1
-
57
-
-
60549106099
-
Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice
-
57 Ahmed, M., et al. Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J. Immunol. 182 (2009), 784–792.
-
(2009)
J. Immunol.
, vol.182
, pp. 784-792
-
-
Ahmed, M.1
-
58
-
-
41149170727
-
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
-
58 Yager, E.J., et al. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 205 (2008), 711–723.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 711-723
-
-
Yager, E.J.1
-
59
-
-
0037103256
-
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
-
59 Khan, N., et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169 (2002), 1984–1992.
-
(2002)
J. Immunol.
, vol.169
, pp. 1984-1992
-
-
Khan, N.1
-
60
-
-
14744281718
-
+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
-
+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J. Virol. 79 (2005), 3675–3683.
-
(2005)
J. Virol.
, vol.79
, pp. 3675-3683
-
-
Almanzar, G.1
-
61
-
-
40849145398
-
T cell subset-specific susceptibility to aging
-
61 Czesnikiewicz-Guzik, M., et al. T cell subset-specific susceptibility to aging. Clin. Immunol. 127 (2008), 107–118.
-
(2008)
Clin. Immunol.
, vol.127
, pp. 107-118
-
-
Czesnikiewicz-Guzik, M.1
-
62
-
-
84896296917
-
Regulatory T cells and the immune aging process: a mini-review
-
62 Jagger, A., et al. Regulatory T cells and the immune aging process: a mini-review. Gerontology 60 (2014), 130–137.
-
(2014)
Gerontology
, vol.60
, pp. 130-137
-
-
Jagger, A.1
-
63
-
-
20444497416
-
high regulatory T cells increases with age
-
high regulatory T cells increases with age. Clin. Exp. Immunol. 140 (2005), 540–546.
-
(2005)
Clin. Exp. Immunol.
, vol.140
, pp. 540-546
-
-
Gregg, R.1
-
64
-
-
73349101903
-
Key role of T cell defects in age-related vulnerability to West Nile virus
-
64 Brien, J.D., et al. Key role of T cell defects in age-related vulnerability to West Nile virus. J. Exp. Med. 206 (2009), 2735–2745.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2735-2745
-
-
Brien, J.D.1
-
65
-
-
29644443961
-
Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo
-
65 Messaoudi, I., et al. Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. J. Immunol. 176 (2006), 301–308.
-
(2006)
J. Immunol.
, vol.176
, pp. 301-308
-
-
Messaoudi, I.1
-
66
-
-
70349689918
-
The aging of the immune system
-
66 Weiskopf, D., et al. The aging of the immune system. Transpl. Int. 22 (2009), 1041–1050.
-
(2009)
Transpl. Int.
, vol.22
, pp. 1041-1050
-
-
Weiskopf, D.1
-
67
-
-
0036083314
-
Defective generation but normal maintenance of memory T cells in old mice
-
67 Kapasi, Z.F., et al. Defective generation but normal maintenance of memory T cells in old mice. Eur. J. Immunol. 32 (2002), 1567–1573.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1567-1573
-
-
Kapasi, Z.F.1
-
68
-
-
0344304396
-
CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
-
68 Haynes, L., et al. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc. Natl. Acad. Sci. U.S.A. 100 (2003), 15053–15058.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 15053-15058
-
-
Haynes, L.1
-
69
-
-
33646871426
-
+ T cells in aged mice
-
+ T cells in aged mice. J. Immunol. 176 (2006), 6586–6593.
-
(2006)
J. Immunol.
, vol.176
, pp. 6586-6593
-
-
Nishioka, T.1
-
70
-
-
34249713646
-
+ regulatory T cells in aged Balb/c mice
-
+ regulatory T cells in aged Balb/c mice. J. Leukoc. Biol. 81 (2007), 1386–1394.
-
(2007)
J. Leukoc. Biol.
, vol.81
, pp. 1386-1394
-
-
Zhao, L.1
-
71
-
-
84860887914
-
Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells
-
71 Sun, L., et al. Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging cell 11 (2012), 509–519.
-
(2012)
Aging cell
, vol.11
, pp. 509-519
-
-
Sun, L.1
-
72
-
-
84911103917
-
+ T cell survival and memory formation
-
+ T cell survival and memory formation. Nat. Immunol. 15 (2014), 1152–1161.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 1152-1161
-
-
Xu, X.1
-
73
-
-
78650643194
-
Macroautophagy regulates energy metabolism during effector T cell activation
-
73 Hubbard, V.M., et al. Macroautophagy regulates energy metabolism during effector T cell activation. J. Immunol. 185 (2010), 7349–7357.
-
(2010)
J. Immunol.
, vol.185
, pp. 7349-7357
-
-
Hubbard, V.M.1
-
74
-
-
84964304860
-
Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1
-
74 Jia, W., et al. Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. Autophagy 11 (2015), 2335–2345.
-
(2015)
Autophagy
, vol.11
, pp. 2335-2345
-
-
Jia, W.1
-
75
-
-
33846461678
-
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
-
75 Pua, H.H., et al. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J. Exp. Med. 204 (2007), 25–31.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 25-31
-
-
Pua, H.H.1
-
76
-
-
64249123646
-
Autophagy is essential for mitochondrial clearance in mature T lymphocytes
-
76 Pua, H.H., et al. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J. Immunol. 182 (2009), 4046–4055.
-
(2009)
J. Immunol.
, vol.182
, pp. 4046-4055
-
-
Pua, H.H.1
-
77
-
-
79955540204
-
Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy
-
77 Jia, W., He, Y.W., Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J. Immunol. 186 (2011), 5313–5322.
-
(2011)
J. Immunol.
, vol.186
, pp. 5313-5322
-
-
Jia, W.1
He, Y.W.2
-
79
-
-
84862151014
-
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells
-
79 Phadwal, K., et al. A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells. Autophagy 8 (2012), 677–689.
-
(2012)
Autophagy
, vol.8
, pp. 677-689
-
-
Phadwal, K.1
-
80
-
-
70449529855
-
Induction of autophagy by spermidine promotes longevity
-
80 Eisenberg, T., et al. Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11 (2009), 1305–1314.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1305-1314
-
-
Eisenberg, T.1
-
81
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
81 Araki, K., et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460 (2009), 108–112.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
-
82
-
-
84877832630
-
Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34
-
82 Parekh, V.V., et al. Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. J. Immunol. 190 (2013), 5086–5101.
-
(2013)
J. Immunol.
, vol.190
, pp. 5086-5101
-
-
Parekh, V.V.1
-
83
-
-
84955590563
-
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
-
83 Wei, J., et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat. Immunol. 17 (2016), 277–285.
-
(2016)
Nat. Immunol.
, vol.17
, pp. 277-285
-
-
Wei, J.1
-
84
-
-
84961262270
-
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation
-
84 Kabat, A.M., et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife, 5, 2016, e12444.
-
(2016)
Elife
, vol.5
, pp. e12444
-
-
Kabat, A.M.1
-
85
-
-
0036847971
-
Aging and developmental transitions in the B cell lineage
-
85 Johnson, K.M., et al. Aging and developmental transitions in the B cell lineage. Int. Immunol. 14 (2002), 1313–1323.
-
(2002)
Int. Immunol.
, vol.14
, pp. 1313-1323
-
-
Johnson, K.M.1
-
86
-
-
0037094083
-
Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire
-
86 Johnson, S.A., et al. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J. Immunol. 168 (2002), 5014–5023.
-
(2002)
J. Immunol.
, vol.168
, pp. 5014-5023
-
-
Johnson, S.A.1
-
87
-
-
84892778834
-
Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires
-
87 Wang, C., et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J. Immunol. 192 (2014), 603–611.
-
(2014)
J. Immunol.
, vol.192
, pp. 603-611
-
-
Wang, C.1
-
88
-
-
84956906071
-
Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues
-
88 Tabibian-Keissar, H., et al. Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues. Eur. J. Immunol. 46 (2016), 480–492.
-
(2016)
Eur. J. Immunol.
, vol.46
, pp. 480-492
-
-
Tabibian-Keissar, H.1
-
89
-
-
82855177831
-
Elderly subjects have a delayed antibody response and prolonged viraemia following yellow fever vaccination: a prospective controlled cohort study
-
89 Roukens, A.H., et al. Elderly subjects have a delayed antibody response and prolonged viraemia following yellow fever vaccination: a prospective controlled cohort study. PloS ONE, 6, 2011, e27753.
-
(2011)
PloS ONE
, vol.6
, pp. e27753
-
-
Roukens, A.H.1
-
90
-
-
79960997012
-
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
-
90 Sasaki, S., et al. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J. Clin. Invest. 121 (2011), 3109–3119.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 3109-3119
-
-
Sasaki, S.1
-
91
-
-
45949103917
-
Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
-
91 Frasca, D., et al. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J. Immunol. 180 (2008), 5283–5290.
-
(2008)
J. Immunol.
, vol.180
, pp. 5283-5290
-
-
Frasca, D.1
-
92
-
-
84869750763
-
Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues
-
92 Frasca, D., Blomberg, B.B., Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues. Aging Dis. 2 (2011), 361–373.
-
(2011)
Aging Dis.
, vol.2
, pp. 361-373
-
-
Frasca, D.1
Blomberg, B.B.2
-
93
-
-
78649641896
-
Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
-
93 Frasca, D., et al. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine 28 (2010), 8077–8084.
-
(2010)
Vaccine
, vol.28
, pp. 8077-8084
-
-
Frasca, D.1
-
94
-
-
41449106674
-
The autophagy gene ATG5 plays an essential role in B lymphocyte development
-
94 Miller, B.C., et al. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 4 (2008), 309–314.
-
(2008)
Autophagy
, vol.4
, pp. 309-314
-
-
Miller, B.C.1
-
95
-
-
84874097064
-
Plasma cells require autophagy for sustainable immunoglobulin production
-
95 Pengo, N., et al. Plasma cells require autophagy for sustainable immunoglobulin production. Nat. Immunol. 14 (2013), 298–305.
-
(2013)
Nat. Immunol.
, vol.14
, pp. 298-305
-
-
Pengo, N.1
-
96
-
-
84924546608
-
Requirement for autophagy in the long-term persistence but not initial formation of memory B cells
-
96 Chen, M., et al. Requirement for autophagy in the long-term persistence but not initial formation of memory B cells. J. Immunol. 194 (2015), 2607–2615.
-
(2015)
J. Immunol.
, vol.194
, pp. 2607-2615
-
-
Chen, M.1
-
97
-
-
33748141968
-
B-1 B cells: development, selection, natural autoantibody and leukemia
-
97 Hardy, R.R., B-1 B cells: development, selection, natural autoantibody and leukemia. Curr. Opin. Immunol. 18 (2006), 547–555.
-
(2006)
Curr. Opin. Immunol.
, vol.18
, pp. 547-555
-
-
Hardy, R.R.1
-
98
-
-
0037425564
-
Mortality associated with influenza and respiratory syncytial virus in the United States
-
98 Thompson, W.W., et al. Mortality associated with influenza and respiratory syncytial virus in the United States. Jama 289 (2003), 179–186.
-
(2003)
Jama
, vol.289
, pp. 179-186
-
-
Thompson, W.W.1
-
99
-
-
67651026829
-
Influenza control in the 21st century: optimizing protection of older adults
-
99 Monto, A.S., et al. Influenza control in the 21st century: optimizing protection of older adults. Vaccine 27 (2009), 5043–5053.
-
(2009)
Vaccine
, vol.27
, pp. 5043-5053
-
-
Monto, A.S.1
-
100
-
-
79953199370
-
Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
-
100 Chen, W.H., et al. Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine. Vaccine 29 (2011), 2865–2873.
-
(2011)
Vaccine
, vol.29
, pp. 2865-2873
-
-
Chen, W.H.1
-
101
-
-
84959462594
-
Homeostatic control of innate lung inflammation by Vici syndrome gene Epg5 and additional autophagy genes promotes influenza pathogenesis
-
101 Lu, Q., et al. Homeostatic control of innate lung inflammation by Vici syndrome gene Epg5 and additional autophagy genes promotes influenza pathogenesis. Cell Host Microbe. 19 (2016), 102–113.
-
(2016)
Cell Host Microbe.
, vol.19
, pp. 102-113
-
-
Lu, Q.1
-
102
-
-
84908137655
-
Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells
-
102 Hubbard-Lucey, V.M., et al. Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity 41 (2014), 579–591.
-
(2014)
Immunity
, vol.41
, pp. 579-591
-
-
Hubbard-Lucey, V.M.1
-
103
-
-
51049091671
-
Impaired dendritic cell function in aging leads to defective antitumor immunity
-
103 Grolleau-Julius, A., et al. Impaired dendritic cell function in aging leads to defective antitumor immunity. Cancer Res. 68 (2008), 6341–6349.
-
(2008)
Cancer Res.
, vol.68
, pp. 6341-6349
-
-
Grolleau-Julius, A.1
-
104
-
-
84858760109
-
Combining immunotherapy and targeted therapies in cancer treatment
-
104 Vanneman, M., Dranoff, G., Combining immunotherapy and targeted therapies in cancer treatment. Nat. Rev. Cancer. 12 (2012), 237–251.
-
(2012)
Nat. Rev. Cancer.
, vol.12
, pp. 237-251
-
-
Vanneman, M.1
Dranoff, G.2
-
105
-
-
79958030075
-
Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
-
105 Ouimet, M., et al. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 13 (2011), 655–667.
-
(2011)
Cell Metab.
, vol.13
, pp. 655-667
-
-
Ouimet, M.1
-
106
-
-
67650602355
-
Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
-
106 Chen, W.Q., et al. Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels. Br. J. Pharmacol. 156 (2009), 941–951.
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 941-951
-
-
Chen, W.Q.1
-
107
-
-
84875365804
-
Autophagosomes form at ER–mitochondria contact sites
-
107 Hamasaki, M., et al. Autophagosomes form at ER–mitochondria contact sites. Nature 495 (2013), 389–393.
-
(2013)
Nature
, vol.495
, pp. 389-393
-
-
Hamasaki, M.1
-
108
-
-
84939804206
-
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
-
108 Lazarou, M., et al. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524 (2015), 309–314.
-
(2015)
Nature
, vol.524
, pp. 309-314
-
-
Lazarou, M.1
-
109
-
-
84927636147
-
Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy
-
109 Milan, G., et al. Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy. Nat. Commun., 6, 2015, 6670.
-
(2015)
Nat. Commun.
, vol.6
, pp. 6670
-
-
Milan, G.1
-
110
-
-
84902185782
-
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression
-
110 Cheng, C.W., et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 14 (2014), 810–823.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 810-823
-
-
Cheng, C.W.1
-
111
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
111 Settembre, C., et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 31 (2012), 1095–1108.
-
(2012)
EMBO J.
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
-
112
-
-
75549090275
-
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
112 Chen, C., et al. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal., 2, 2009, ra75.
-
(2009)
Sci. Signal.
, vol.2
, pp. ra75
-
-
Chen, C.1
-
113
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
113 Egan, D.F., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331 (2011), 456–461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
-
114
-
-
84872586081
-
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
-
114 Kim, J., et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 (2013), 290–303.
-
(2013)
Cell
, vol.152
, pp. 290-303
-
-
Kim, J.1
-
115
-
-
84855182851
-
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
-
115 Salminen, A., Kaarniranta, K., AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res. Rev. 11 (2012), 230–241.
-
(2012)
Ageing Res. Rev.
, vol.11
, pp. 230-241
-
-
Salminen, A.1
Kaarniranta, K.2
-
116
-
-
67349276169
-
+ metabolism and SIRT1 activity
-
+ metabolism and SIRT1 activity. Nature 458 (2009), 1056–1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
-
117
-
-
41549138483
-
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
-
117 Lee, I.H., et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105 (2008), 3374–3379.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 3374-3379
-
-
Lee, I.H.1
-
118
-
-
84860477354
-
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
-
118 Price, N.L., et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15 (2012), 675–690.
-
(2012)
Cell Metab.
, vol.15
, pp. 675-690
-
-
Price, N.L.1
-
119
-
-
84883476818
-
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
-
119 Satoh, A., et al. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 18 (2013), 416–430.
-
(2013)
Cell Metab.
, vol.18
, pp. 416-430
-
-
Satoh, A.1
-
120
-
-
84963815042
-
Adverse effects of AMP-activated protein kinase alpha2-subunit deletion and high-fat diet on heart function and ischemic tolerance in aged female mice
-
120 Slámová, K., et al. Adverse effects of AMP-activated protein kinase alpha2-subunit deletion and high-fat diet on heart function and ischemic tolerance in aged female mice. Physiol. Res. 65 (2016), 33–42.
-
(2016)
Physiol. Res.
, vol.65
, pp. 33-42
-
-
Slámová, K.1
-
121
-
-
79955591489
-
+ metabolism oxidative stress and Sirt1 activity in wistar rats
-
+ metabolism oxidative stress and Sirt1 activity in wistar rats. PloS ONE, 6, 2011, e19194.
-
(2011)
PloS ONE
, vol.6
, pp. e19194
-
-
Braidy, N.1
-
122
-
-
84871011474
-
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
-
122 Hughes, A.L., Gottschling, D.E., An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492 (2012), 261–265.
-
(2012)
Nature
, vol.492
, pp. 261-265
-
-
Hughes, A.L.1
Gottschling, D.E.2
-
123
-
-
0034766880
-
Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin
-
123 Shamsi, A., Boulton, M., Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin. Invest. Ophthalmol. Vis. Sci. 42 (2001), 3041–3046.
-
(2001)
Invest. Ophthalmol. Vis. Sci.
, vol.42
, pp. 3041-3046
-
-
Shamsi, A.1
Boulton, M.2
-
124
-
-
0032730787
-
Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation
-
124 Terman, A., et al. Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp. Gerontol. 34 (1999), 943–957.
-
(1999)
Exp. Gerontol.
, vol.34
, pp. 943-957
-
-
Terman, A.1
-
125
-
-
77953669656
-
Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
-
125 Seidler, S., et al. Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol., 11, 2010, 30.
-
(2010)
BMC Immunol.
, vol.11
, pp. 30
-
-
Seidler, S.1
-
126
-
-
0035116898
-
IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice
-
126 Herrero, C., et al. IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J. Clin. Invest. 107 (2001), 485–493.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 485-493
-
-
Herrero, C.1
-
127
-
-
84890828734
-
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
-
127 Romao, S., et al. Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. J. Cell Biol. 203 (2013), 757–766.
-
(2013)
J. Cell Biol.
, vol.203
, pp. 757-766
-
-
Romao, S.1
-
128
-
-
84991095640
-
Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice
-
128 Takahashi, R., et al. Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice. Geriatr. Gerontol. Int., 2015.
-
(2015)
Geriatr. Gerontol. Int.
-
-
Takahashi, R.1
-
129
-
-
34249775503
-
Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
-
129 Agrawal, A., et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 178 (2007), 6912–6922.
-
(2007)
J. Immunol.
, vol.178
, pp. 6912-6922
-
-
Agrawal, A.1
-
130
-
-
76949091325
-
In vivo requirement for Atg5 in antigen presentation by dendritic cells
-
130 Lee, H.K., et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity 32 (2010), 227–239.
-
(2010)
Immunity
, vol.32
, pp. 227-239
-
-
Lee, H.K.1
-
131
-
-
84883367287
-
Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection
-
131 Reed, M., et al. Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection. J. Immunol. 191 (2013), 2526–2537.
-
(2013)
J. Immunol.
, vol.191
, pp. 2526-2537
-
-
Reed, M.1
|