Aging and developmental transitions in the B cell lineage

International Immunology

Volumn 14, Issue 11, 2002, Pages 1313-1323

  Johnson, Kara M ^a   Owen, Kevin ^a   Witte, Pamela L ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5 bromo 2 deoxyuridine; Aging; B lymphopoiesis; Cellular differentiation; Flow cytometry

Indexed keywords

BROXURIDINE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL MATURATION; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; LYMPHOCYTE COUNT; LYMPHOID CELL LINE; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TURNOVER TIME; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW; CELL AGING; CELL DIFFERENTIATION; FLOW CYTOMETRY; IMMUNOLOGY; KINETICS; METABOLISM; SPLEEN; STAINING;

AGING; ANIMALS; B-LYMPHOCYTES; BONE MARROW; BROMODEOXYURIDINE; CELL AGING; CELL DIFFERENTIATION; FEMALE; FLOW CYTOMETRY; KINETICS; MICE; MICE, INBRED BALB C; SPLEEN; STAINING AND LABELING;

EID: 0036847971     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxf092     Document Type: Article

References (35)

1. Kay, M. M. B. and Makinodan, T. 1981. Relationship between aging and the immune system. Prog. Allergy 29:134.
2. LeMaoult, J., Szabo, P. and Weksler, M. E. 1997. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol. Rev. 160:115.
3. Schneider, E. L. 1983. Infectious diseases in the elderly. Ann. Intern. Med. 98:395.
4. Yang, X., Stedra, J. and Cerny, J. 1996. Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J. Exp. Med. 183:959.
5. Krogsrud, R. L. and Perkins, E. H. 1977. Age-related changes in T cell function. J. Immunol. 118:1607.
6. Miller, R. A. 1996. The aging immune system: primer and prospectus. Science 273:70.
7. Doria, G., D'Agostaro, G. and Poretti, A. 1978. Age-dependent variations of antibody avidity. Immunology 35:601.
8. Goidl, E. A., Innes, J. B. and Weksler, M. E. 1976. Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice. J. Exp. Med. 144:1037.
9. L gene repertoire and in specificity. J. Immunol. 147:2750.
10. H gene segment utilization in the response to phosphorylcholine by aged mice. J. Immunol. 143:3798.
11. Manoussakis, M. N., Tzioufas, A. G., Silis, M. P., Pange, P. J., Goudevenos, J. and Moutsopoulos, H. M. 1987. High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin. Exp. Immunol. 69:557.
12. Hayashi, Y., Kurashima, C., Utsuyama, M. and Hirokawa, K. 1989. An animal model of autoimmune sialadenitis in aged mice. Pathol. Immunopathol. Res. 8:118.
13. Rolink, A. and Melchers, F. 1991. Molecular and cellular origins of B lymphocyte diversity. Cell 66:1081.
14. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
15. hi and exhibit unique signaling characteristics. J. Immunol. 149:2533.
16. Allman, D. M., Ferguson, S. E., Lentz, V. M. and Cancro, M. P. 1993, Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 151:4431.
17. Carsetti, R., Kohler, G. and Lamers, M. C. 1995. Transitional B cells are the target of negative selection in the B cell compartment. J. Exp. Med. 181:2129.
18. Stutman, O. and Good, R. A. 1974. Duration of thymic function. Ser. Haematol. 7:505.
19. Riley, R. L., Kruger, M. G. and Elia, J. 1991. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro. Clin. Immunol. Immunopathol. 59:301.
20. Zharhary, D. 1988. Age-related changes in the capability of the bone marrow to generate B cells. J. Immunol. 141:1863.
21. Stephan, R. P., Sanders, V. M. and Witte, P. L. 1996. Stage-specific alterations in murine B lymphopoiesis with age. Int. Immunol. 8:509.
22. Kirman, I., K. Zhao, Y. Wang, P. Szabo, W. Telford, M. E, Weksler. 1998. Increased apoptosis of bone marrow pre-B cells in old mice associated with their low number. Int. Immunol. 10:1385.
23. Sherwood, E. M., Blomberg, B. B., Xu, W., Warner, C. A. and Riley, R. L. 1998. Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment. J. Immunol. 161:4472.
24. Forster, I. and Rajewsky, K. 1990. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc. Natl Acad. Sci. USA 87:4781.
25. Fulcher, D. A. and Basten, A. 1997. Influences on the lifespan of B cell subpopulations defined by different phenotypes. Eur. J. Immunol. 27:1188.
26. Kline, G. H., Hayden, T. A. and Klinman, N. R. 1999. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J. Immunol. 162:3342.
27. Tough, D. F. and Sprent, J. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127.
28. Osmond, D. G., Hales, P. 1996. Methodology of lymphocyte kinetics. In Herzenberg, L. A., Weir, D. M., Herzenberg, L. A. and Blackwell, C. ed., Weir's Handbook of Experimental Immunology, p. 209.1. Blackwell Science, Cambridge, MA.
29. Opstelten, D. and Osmond, D. G. 1983. Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice. J. Immunol. 131:2635.
30. Gu, H., Tarlinton, D., Muller, W., Rajewsky, K. and Forster, I. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357.
31. ten Boekel, E., Melchers, F. and Rolink, A. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013.
32. Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A. and Goodnow, C. C. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72:325.
33. Chen, C., Nagy, Z., Radic, M. Z., Hardy, R. R., Huszar, D., Camper, S. A. and Weigert, M. 1995. The site and stage of anti-DNA B-cell deletion. Nature 373:252.
34. Rolink, A. G., Schaniel, C., Andersson, J. and Melchers, F. 2001. Selection events operating at various stages in B cell development. Curr. Opin. Immunol. 13:202.
35. Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E. and Scott, M. L. 2001. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293:2111.